The Role of Alpha Atrial Natriuretic Hormone in Pneumonectomy: An Experimental Study
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Tarih
2019
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The alpha atrial natriuretic hormone (?-ANH) is released in response to atrialdistension and excessive fluid volume in the body. The aim of the present study was to evaluate ?-ANH levels before and after pneumonectomy and to investigate the effects of normaland increased volume of crystalloid–colloid fluids on ?-ANH following pneumonectomy ina rabbit model.Methods: A total of 20 New Zealand rabbits were used in the study. The mean weightof the rabbits was 1.831 g. The subjects were divided into four groups with five in eachgroup. The first group was given 3 mL/kg/h of crystalloid; the second group was given 10mL/kg/h of crystalloid; the third group was given 3 mL/kg/h of colloid; the fourth group wasgiven 10 mL/kg/h of colloid. Blood samples were preoperatively collected from the jugularvein. Posterolateral thoracotomy was applied to all subjects. The hilus was tied and cut enbloc with 2/0 silk, and pneumonectomy was performed. All groups received infusion for 3h. Following infusion, blood samples from the contralateral jugular vein were collected atpostoperative 3 h. Pre- and postoperative ?-ANH levels were compared.Results: There was no significant difference in the mean weight of the groups (?2=1.417,p=0.478). There was no significant difference in the pre- and postoperative ?-ANH levelsamong all groups (Z=0.674, p=0.5 in the first; Z=0.405, p=0.686 in the second; Z=1.753,p=0.08 in the third; Z=0.944, p=0.345 in the fourth).Conclusion: Our study results suggest that pneumonectomy alone appears not to changethe ?-ANH levels, and hypoxia, increased atrial pressure, and some neurohormonal factorsmay enhance ?-ANH release.
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Kaynak
Southern Clinics of Istanbul Eurasia
WoS Q Değeri
Scopus Q Değeri
Cilt
30
Sayı
2
