Factors related to exercise capacity in asymptomatic middle-aged type 2 diabetic patients
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: We aimed to look at the relationship between exercise capacity and metabolic variables in unselected consecutive asymptomatic middle-aged type 2 diabetic patients as a potential marker for undiagnosed coronary heart disease. Method: Ninety patients (49 6 years) were included in the study. All patients performed a treadmill exercise test using the Bruce protocol. According to achieved EC, patients were separated into three groups; Group I (n, 24) 8 > metabolic equivalents (METs) greater than or equal to 5, Group II (n, 54) 11 > METs > 8 and Group III (n, 12) METs > 11. Results: Patients in group I are more likely to be of female gender and to have a family history of coronary heart disease (CHD) than in group III (P = 0.015, P = 0.009, respectively). When compared to group 111, patients in group I had higher fasting insulin and fibrinogen levels (P = 0.049 and P = 0.01, respectively). Homeostasis model assessment for insulin resistance (HOMA-IR) index (P = 0.03) was also higher in group I than in group III. We found a significant negative correlation between achieved exercise capacity and age (r = -0.204, P = 0.048), fasting insulin (r = -0.209, P = 0.048), HOMA-IR (r = -0.204, P = 0.048) as well as fibrinogen (r = -0.301, P = 0.007). Conclusion: Reduced exercise capacity was associated with increased insulin resistance as assessed by HOMA-IR index in asymptornatic middle-aged type 2 diabetic patients. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Type 2 Diabetes, Exercise Test, Exercise Capacity, Insulin Resistance, Heart-Rate Recovery, Prognostic Value, Insulin Sensitivity, Follow-Up, All-Cause, Mortality, Predictor, Hyperinsulinemia, Association, Dysfunction
Kaynak
Diabetes Research And Clinical Practice
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
67
Sayı
2
