High-Normal Thyroid-Stimulating Hormone in Euthyroid Subjects is Associated with Risk of Mortality and Composite Disease Endpoint only in Women

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dc.authoridhttp://orcid.org/0000-0001-7112-3970en_US
dc.contributor.authorAltay, Servet
dc.contributor.authorOnat, Altan
dc.contributor.authorCan, Gunay
dc.contributor.authorTusun, Eyyup
dc.contributor.authorSimsek, Baris
dc.contributor.authorKaya, Adnan
dc.date.accessioned2019-12-23T08:15:31Z
dc.date.available2019-12-23T08:15:31Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Anabilim Dalıen_US
dc.description.abstractIntroduction: The aim of the study was to evaluate whether serum thyroid-stimulating hormone (TSH) within the normal range in euthyroid subjects (having normal free triiodothyronine (fT3) and thyroxine (fT4)) is related to the risk of overall mortality or a composite endpoint of death and nonfatal events. Material and methods: In 614 middle-aged adult hospital screenees, free of uncontrolled diabetes at baseline, the association of sex-specific TSH tertiles with death was prospectively assessed using Cox regression, with the composite endpoint assessed using logistic regression in adjusted analyses, stratified by gender. Results: In total, 64 deaths and additional incident nonfatal events in 141 cases were recorded at a mean 7.55 years' follow-up. Multivariable linear regression revealed TSH to be significantly associated among men with age (p = 0.006), but in women inversely with fT3 and fT4 (p < 0.001, and p = 0.024 respectively). In logistic regression analysis, adjusted for age, fT3, fT4, systolic blood pressure and serum total cholesterol, sex-specific baseline TSH tertiles were associated in men neither with the risk of death nor with composite endpoint. In contrast, in women, the highest compared with the bottom TSH tertile predicted the risk of composite endpoint (relative risk: 2.02, 95% CI: 1.07-3.82) and, much more strongly, the mortality risk, independently of fT4 increments. Conclusions: The significant association of higher range of normal serum TSH in euthyroid middle-aged adults with the risk of death and nonfatal adverse outcomes in women alone cannot be accounted for by the action of thyroid hormone and is consistent with involvement of TSH in the pro-inflammatory state.en_US
dc.identifier.citationAltay, S., Onat, A., Can, G., Tusun, E., Şimşek, B., & Kaya, A. (2018). High-normal thyroid-stimulating hormone in euthyroid subjects is associated with risk of mortality and composite disease endpoint only in women. Archives of medical science: AMS, 14(6), 1394.en_US
dc.identifier.doi10.5114/aoms.2016.63264en_US
dc.identifier.endpage1403en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue6en_US
dc.identifier.pmid30393495en_US
dc.identifier.scopus2-s2.0-85055773985en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1394en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4875
dc.identifier.volume14en_US
dc.identifier.wosWOS:000448045000021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTERMEDIA PUBLISHING HOUSE LTDen_US
dc.relation.ispartofJournal Citation Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectCardiovascular Eventsen_US
dc.subjectEuthyroid Statusen_US
dc.subjectMortalityen_US
dc.subjectPro-inflammatory Stateen_US
dc.subjectThyroid Hormonesen_US
dc.subjectThyroid-Stimulating Hormoneen_US
dc.subjectHigh-Density-Lipoproteinen_US
dc.subjectAutoimmune Activationen_US
dc.subjectThyrotropin Levelsen_US
dc.subjectSerum Creatinineen_US
dc.subjectDysfunctionen_US
dc.subjectRangeen_US
dc.subjectInflammationen_US
dc.subjectTshen_US
dc.subjectHdlen_US
dc.subjectMenen_US
dc.titleHigh-Normal Thyroid-Stimulating Hormone in Euthyroid Subjects is Associated with Risk of Mortality and Composite Disease Endpoint only in Womenen_US
dc.typeArticleen_US

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