The effect on bone-mineral density of perindopril as an antihypertensive drug in osteoporosis patients

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dc.authorscopusid7006765901
dc.authorscopusid55882042100
dc.authorscopusid23391476900
dc.contributor.authorÖzdemir F.
dc.contributor.authorTaştekin N.
dc.contributor.authorZateri C.
dc.date.accessioned2024-06-12T10:28:36Z
dc.date.available2024-06-12T10:28:36Z
dc.date.issued2006
dc.description.abstractObjective: The purpose of this study was to investigate the effect on bone-mineral density (BMD) of perindopril as an antihypertensive treatment in conjunction with osteoporosis treatment in hypertensive postmenopausal women. Material and Methods: Seventy postmenopausal women treated with alendronate were enrolled in this study. Menopausal women with osteoporosis and mild or moderate hypertension were administered perindopril 4 mg/day, alendronate 70 mg/week and calcium 1000 mg/day (group 1; n= 36 patients). The other group consisted of postmenopausal women without hypertension treated by alendronate 70 mg/week and calcium 1000 mg/day (group 2; n= 34 patients). BMD of patients was evaluated before and after 1 year of treatment. Results: BMD results suggested significant improvements in L2-L4, L2 and L4 scores in both groups after 1 year of treatment. For the L3 score, although there was no difference in group 1, improvement was detected in group 2. In the trochanter region, we did not observe a significant improvement in any group; however, significant improvement was detected in the femur neck only in group 2. There was no significant difference in BMD values between the two groups after treatment (p> 0.05). Conclusion: In conclusion, according to the results of 1-year treatment, the use of perindopril for concurrent hypertension in patients using alendronate for postmenopausal osteoporosis does not have a clear negative effect on BMD values. Copyright © 2006 by Türkiye Klinikleri.en_US
dc.identifier.endpage379en_US
dc.identifier.issn1300-0292
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-33750412350en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage375en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17332
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Density; Osteoporosis; Perindopril; Postmenopausalen_US
dc.subjectAlendronic Acid; Antihypertensive Agent; Calcium; Perindopril; Adult; Aged; Antihypertensive Therapy; Article; Bone Density; Controlled Study; Disease Severity; Drug Effect; Female; Femur Neck; Human; Hypertension; Lumbar Spine; Major Clinical Study; Postmenopause; Postmenopause Osteoporosisen_US
dc.titleThe effect on bone-mineral density of perindopril as an antihypertensive drug in osteoporosis patientsen_US
dc.title.alternativeOsteoporozlu hastalarda antihipertansif i?laç olarak perindoprilin kemik mineral yo?unlu?una etkisien_US
dc.typeArticleen_US

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