EFFECT OF EFFLUX PUMP (DAP) INHIBITORS TO EFFICACY OF MEROPENEM ON ACINETOBACTER SPP. CLINICAL ISOLATES

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dc.authorscopusid6505770428
dc.authorscopusid57479331400
dc.authorscopusid57217235268
dc.authorscopusid23034973800
dc.contributor.authorÖkten S.
dc.contributor.authorSalan A.S.
dc.contributor.authorKuyucuklu G.
dc.contributor.authorOnurdağ F.K.
dc.date.accessioned2024-06-12T10:25:59Z
dc.date.available2024-06-12T10:25:59Z
dc.date.issued2022
dc.description.abstractObjective: In addition to the synthesis of new antimicrobial compounds for the treatment of resistant bacterial infections, there are also studies on the use of inhibitor molecules in combination with antibiotics. In our study, it was aimed to determine the minimum inhibitory concentration (MIC) of phenylalanine-arginine-beta-naphthylamide (PA?N), carbonyl-cyanide m-chlorophenylhydrazone (CCCP) and 1-(1naphthylmethyl) - piperazine (NMP) on Acinetobacter baumannii clinical isolates (MIC). Material and Method: To be used in our study, 50 A. baumannii isolates from A. baumannii isolates obtained from Trakya University Health Research and Application Center, which were confirmed to be resistant to meropenem, were included in the study. Meropenem susceptibility was re-investigated in the presence of PA?N, CCCP and NMP. Antimicrobial susceptibility tests were performed by microdilution method. FIC indexes were calculated according to the checkerboard test results and the effect of the combination was defined as synergistic or additive. Result and Discussion: As a result, although ideal concentrations of meropenem that decrease MIC values were determined in isolates, it was determined that the increase in the amount of meropenem was accompanied by the decrease in the inhibitor concentration or the increase in the inhibitor concentration with the decrease in the meropenem concentration. Although the MIC values decrease dupto 8 times, the inhibitor concentration that lowered the MIC value of meropenem below the resistance limit was not detected. © 2022 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.995682
dc.identifier.endpage47en_US
dc.identifier.issn2564-6524
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85125837242en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage35en_US
dc.identifier.trdizinid1111889en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.995682
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1111889
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16614
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcinetobacter Baumannii; Dap Inhibitor; Meropenemen_US
dc.subject1 (1naphthylmethyl)Piperazine; Carbonyl Cyanide Chlorophenylhydrazone; Meropenem; Phenylalanine; Phenylalanine Arginine Beta Naphthylamide; Piperazine Derivative; Unclassified Drug; Acinetobacter; Antibiotic Resistance; Antibiotic Sensitivity; Article; Bacterium Isolate; Broth Dilution; Concentration Process; Controlled Study; Drug Efficacy; Fractional Inhibitory Concentration Index; Medical Research; Minimum Inhibitory Concentration; Nonhuman; Synergistic Effecten_US
dc.titleEFFECT OF EFFLUX PUMP (DAP) INHIBITORS TO EFFICACY OF MEROPENEM ON ACINETOBACTER SPP. CLINICAL ISOLATESen_US
dc.title.alternativeACINETOBACTER SPP. İZOLATLARINDA DIŞA ATIM POMPASI (DAP) İNHİBİTÖRLERİNİN MEROPENEMİN ETKİNLİĞİ ÜZERİNE ETKİSİen_US
dc.typeArticleen_US

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