EFFECT OF EFFLUX PUMP (DAP) INHIBITORS TO EFFICACY OF MEROPENEM ON ACINETOBACTER SPP. CLINICAL ISOLATES
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
University of Ankara
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: In addition to the synthesis of new antimicrobial compounds for the treatment of resistant bacterial infections, there are also studies on the use of inhibitor molecules in combination with antibiotics. In our study, it was aimed to determine the minimum inhibitory concentration (MIC) of phenylalanine-arginine-beta-naphthylamide (PA?N), carbonyl-cyanide m-chlorophenylhydrazone (CCCP) and 1-(1naphthylmethyl) - piperazine (NMP) on Acinetobacter baumannii clinical isolates (MIC). Material and Method: To be used in our study, 50 A. baumannii isolates from A. baumannii isolates obtained from Trakya University Health Research and Application Center, which were confirmed to be resistant to meropenem, were included in the study. Meropenem susceptibility was re-investigated in the presence of PA?N, CCCP and NMP. Antimicrobial susceptibility tests were performed by microdilution method. FIC indexes were calculated according to the checkerboard test results and the effect of the combination was defined as synergistic or additive. Result and Discussion: As a result, although ideal concentrations of meropenem that decrease MIC values were determined in isolates, it was determined that the increase in the amount of meropenem was accompanied by the decrease in the inhibitor concentration or the increase in the inhibitor concentration with the decrease in the meropenem concentration. Although the MIC values decrease dupto 8 times, the inhibitor concentration that lowered the MIC value of meropenem below the resistance limit was not detected. © 2022 University of Ankara. All rights reserved.
Açıklama
Anahtar Kelimeler
Acinetobacter Baumannii; Dap Inhibitor; Meropenem, 1 (1naphthylmethyl)Piperazine; Carbonyl Cyanide Chlorophenylhydrazone; Meropenem; Phenylalanine; Phenylalanine Arginine Beta Naphthylamide; Piperazine Derivative; Unclassified Drug; Acinetobacter; Antibiotic Resistance; Antibiotic Sensitivity; Article; Bacterium Isolate; Broth Dilution; Concentration Process; Controlled Study; Drug Efficacy; Fractional Inhibitory Concentration Index; Medical Research; Minimum Inhibitory Concentration; Nonhuman; Synergistic Effect
Kaynak
Ankara Universitesi Eczacilik Fakultesi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
46
Sayı
1
