Does the efficacy of supplemental oxygen for the prevention of postoperative nausea and vomiting depend on the measured outcome, observational period or site of surgery?
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
High intra-operative oxygen concentration reportedly reduces postoperative nausea and vomiting (PONV), but recent data are conflicting. Therefore, we tested whether the effectiveness of supplemental oxygen depends on the endpoint (nausea vs. vomiting), observation interval (early vs. late) or surgical field (abdominal vs. non-abdominal). We randomly assigned 560 adult patients undergoing various elective procedures with a PONV risk. of at least 40% to intra-operative 80% (supplemental) or 30% oxygen (control). Potential confounding factors were similar between groups. Incidences of nausea were similar in the groups during early (12% (supplemental) vs. 10% (control), p = 0.43) and late intervals, 26% vs. 20%, p = 0.09, as were the incidences of vomiting (early: 2% vs. 3%, p = 0.40; late: 8% vs. 9%, p = 0.75). Supplemental oxygen was no more effective at reducing PONV in abdominal (40% vs. 31%, p = 0.37) than in non-abdominal surgery (25% vs. 21%, p = 0.368). Thus, supplemental oxygen was unable to reduce PONY independent of the endpoint, observational period or site of surgery.
Açıklama
Anahtar Kelimeler
Controlled Trials, Motion Sickness, Risk-Factors, Ondansetron, Placebo, Interventions, Laparoscopy, Safety, Trauma, Reduce
Kaynak
Anaesthesia
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
61
Sayı
7
