The effects of methyleugenol on the liver, kidney and small intestine and on the antioxidant enzymes in rats

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dc.authorscopusid7801322117
dc.authorscopusid8516166200
dc.authorscopusid22134674200
dc.contributor.authorKaboglu A.
dc.contributor.authorErtan F.
dc.contributor.authorKizilay G.
dc.date.accessioned2024-06-12T10:28:21Z
dc.date.available2024-06-12T10:28:21Z
dc.date.issued2009
dc.description.abstractMethyleugenol is a natural, widely used constituent of foods, cosmetics, soaps and shampoos. The purpose of this study was to evaluate the effects of methyleugenol on the liver, kidney and small intestine. Methyleugenol was given by gavage to rats for ten days at doses of 10 mg/kg and 30 mg/kg. In liver, widening of the sinusoidal area, necrotic and hypertrophic hepatocytes, cytoplasmic vacuolization in hepatocytes, degeneration of endothelium, mononuclear cell infiltration, and picnotic nuclei were observed. In kid- ney, loosing of glomerulus, mononuclear cell infiltration, focal bleeding around tubules, degenerative tubules, epithe- lial membrane degeneration, hypertrophic epithelial cells, and accumulation of material in proximal tubules were ob- served. In small intestine, increased mitotic figures in the base of villi, edema in connective tissue, connective-epithe- lial tissue separation, diminished connective tissue in lam- ina propria, a foam-like appearance, and leukocyte infil- tration were observed. There were no significant changes in superoxide dismutase (SOD) and catalase (CAT) activ- ity, but glutathione peroxidase (GPX) activity was signifi-. cantly increased in the kidney and small intestine at 30 mg/ kg (p<0.05). The amount of total protein was significantly increased in liver (p<0.05), but not changed in the kidney and small intestine. We concluded that the toxic effects of methyleugenol must be evaluated in greater detail.en_US
dc.identifier.endpage490en_US
dc.identifier.issn1018-4619
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-66149172129en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage481en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17206
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatalase; Glutathione Peroxidase; Methyleugenol; Superoxide Dismutaseen_US
dc.subjectAntioxidant; Bioaccumulation; Cytoplasm; Ecotoxicology; Enzyme Activity; Organic Compound; Rodent; Rattusen_US
dc.titleThe effects of methyleugenol on the liver, kidney and small intestine and on the antioxidant enzymes in ratsen_US
dc.typeArticleen_US

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