The effects of methyleugenol on the liver, kidney and small intestine and on the antioxidant enzymes in rats
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Methyleugenol is a natural, widely used constituent of foods, cosmetics, soaps and shampoos. The purpose of this study was to evaluate the effects of methyleugenol on the liver, kidney and small intestine. Methyleugenol was given by gavage to rats for ten days at doses of 10 mg/kg and 30 mg/kg. In liver, widening of the sinusoidal area, necrotic and hypertrophic hepatocytes, cytoplasmic vacuolization in hepatocytes, degeneration of endothelium, mononuclear cell infiltration, and picnotic nuclei were observed. In kid- ney, loosing of glomerulus, mononuclear cell infiltration, focal bleeding around tubules, degenerative tubules, epithe- lial membrane degeneration, hypertrophic epithelial cells, and accumulation of material in proximal tubules were ob- served. In small intestine, increased mitotic figures in the base of villi, edema in connective tissue, connective-epithe- lial tissue separation, diminished connective tissue in lam- ina propria, a foam-like appearance, and leukocyte infil- tration were observed. There were no significant changes in superoxide dismutase (SOD) and catalase (CAT) activ- ity, but glutathione peroxidase (GPX) activity was signifi-. cantly increased in the kidney and small intestine at 30 mg/ kg (p<0.05). The amount of total protein was significantly increased in liver (p<0.05), but not changed in the kidney and small intestine. We concluded that the toxic effects of methyleugenol must be evaluated in greater detail.
Açıklama
Anahtar Kelimeler
Catalase; Glutathione Peroxidase; Methyleugenol; Superoxide Dismutase, Antioxidant; Bioaccumulation; Cytoplasm; Ecotoxicology; Enzyme Activity; Organic Compound; Rodent; Rattus
Kaynak
Fresenius Environmental Bulletin
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
18
Sayı
4
