Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.-Mor

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dc.authoridAyaz, Fatma/0000-0003-3994-6576
dc.authoridYILMAZ, Mustafa Abdullah/0000-0002-4090-7227
dc.authoriddogru, tugsen/0000-0003-0101-9742
dc.authorid, Nuraniye/0000-0002-4674-7009
dc.authorwosidAyaz, Fatma/KEJ-5897-2024
dc.authorwosidYILMAZ, Mustafa Abdullah/ABC-3328-2021
dc.authorwosiddogru, tugsen/CAI-4511-2022
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorBuyukyildirim, Tugsen
dc.contributor.authorTetik Rama, Seyma
dc.contributor.authorAyaz, Fatma
dc.contributor.authorTekin, Mehmet
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorAkcakavak, Gokhan
dc.date.accessioned2024-06-12T10:50:22Z
dc.date.available2024-06-12T10:50:22Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAchillea (Asteraceae) species have been traditionally used for their different therapeutical properties. In this study, phytochemical composition of aerial parts of A. sintenisii which is endemic in Turkey was determined with Liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS). To evaluate the wound healing potential, the cream formulation prepared from A. sintenisii was tested on the linear incision wound model in mice. In vitro enzyme inhibitory activity tests were performed on elastase, hyaluronidase, and collagenase. In the histopathological examination, angiogenesis and granulation tissue formation were significantly increased in A. sintenisii treatment groups compared to the negative control group. As a result of this study, it is thought that the enzyme inhibition and antioxidant activity of the plant may contribute to the wound healing process. According to LC/MS/MS analysis result, quinic acid (24.261 mu g/mg extract) and chlorogenic acid (14.97 mu g/mg extract) were identified as main constituents of the extract.en_US
dc.identifier.doi10.1002/cbdv.202201258
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue6en_US
dc.identifier.pmid37203434en_US
dc.identifier.scopus2-s2.0-85159642321en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202201258
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17981
dc.identifier.volume20en_US
dc.identifier.wosWOS:000990200400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAchillea Sintenisiien_US
dc.subjectIn Vivoen_US
dc.subjectIn Vitroen_US
dc.subjectLCen_US
dc.subjectMSen_US
dc.subjectWound Healingen_US
dc.subjectBioassay-Guided Isolationen_US
dc.subjectChlorogenic Acid Therapyen_US
dc.subjectWound-Healing Propertiesen_US
dc.subjectAntiinflammatory Activitiesen_US
dc.subjectAntioxidant Activityen_US
dc.subjectPhenolic Compositionen_US
dc.subjectExtractsen_US
dc.subjectL.en_US
dc.subjectBiebersteiniien_US
dc.subjectMillefoliumen_US
dc.titlePhytochemical Profiling and Biological Activity of Achillea sintenisii Hub.-Moren_US
dc.typeArticleen_US

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