Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.-Mor
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Achillea (Asteraceae) species have been traditionally used for their different therapeutical properties. In this study, phytochemical composition of aerial parts of A. sintenisii which is endemic in Turkey was determined with Liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS). To evaluate the wound healing potential, the cream formulation prepared from A. sintenisii was tested on the linear incision wound model in mice. In vitro enzyme inhibitory activity tests were performed on elastase, hyaluronidase, and collagenase. In the histopathological examination, angiogenesis and granulation tissue formation were significantly increased in A. sintenisii treatment groups compared to the negative control group. As a result of this study, it is thought that the enzyme inhibition and antioxidant activity of the plant may contribute to the wound healing process. According to LC/MS/MS analysis result, quinic acid (24.261 mu g/mg extract) and chlorogenic acid (14.97 mu g/mg extract) were identified as main constituents of the extract.
Açıklama
Anahtar Kelimeler
Achillea Sintenisii, In Vivo, In Vitro, LC, MS, Wound Healing, Bioassay-Guided Isolation, Chlorogenic Acid Therapy, Wound-Healing Properties, Antiinflammatory Activities, Antioxidant Activity, Phenolic Composition, Extracts, L., Biebersteinii, Millefolium
Kaynak
Chemistry & Biodiversity
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
20
Sayı
6
