Synthesis and characterization of a new macrocyclic ligand and its copper (II), cadmium (II), and lead (II) complexes

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dc.authoridUluçam, Gühergül/0000-0001-6481-8483
dc.authoridSİVAS, HÜLYA/0000-0002-8570-8328
dc.authoridBenkli, Kadriye/0000-0002-9042-8718
dc.authorwosidUluçam, Gühergül/AAH-2862-2019
dc.authorwosidSİVAS, HÜLYA/P-7946-2019
dc.contributor.authorBeynek, Nesrin
dc.contributor.authorUlucam, Gueherguel
dc.contributor.authorTueylue, Berrin Ayaz
dc.contributor.authorZeytinoglu, Huelya
dc.contributor.authorBenkli, Kadriye
dc.date.accessioned2024-06-12T10:54:31Z
dc.date.available2024-06-12T10:54:31Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractA new macrocyclic ligand 1,1'-bis(bis-(6,6'-oxymethylenyl-2,2'-bipyridine) binaphthyl, (L), and its complexes CuL(ClO4)(2), CuL(NO3)(2,) 3H(2)O, CdL(ClO4)(2), and PbL(ClO4)(2) have been synthesized and characterized on the basis of IR, H-1 NMR, C-13 NMR, FAB mass, and elemental analyses. Genotoxicity of these metal complexes has also been investigated by cytokinesis- blocked micronucleus assay in cultured human lymphocytes. Blood cultures were set up from two healthy donors, and treatment was done with different test concentrations for 24 and 48 h. The current results indicate that all compounds caused cytotoxicity by decreasing the cell number at the 150 mu g/mL doses for 48-h treatments. On the other hand, CuL(ClO4)(2), CuL(NO3)(2,) 3H(2)O and PbL(ClO4)(2) exhibited genotoxicity by inducing the number of micronucleated cells at doses of 150 mu g/mL for 24-h treatments, but CdL(ClO4)(2) did not significantly alter micronucleus induction. Hence, some test compounds may act as mutagens or produce clastogenic effects depending upon their chemical structures.en_US
dc.identifier.doi10.1080/01480540701522601
dc.identifier.endpage410en_US
dc.identifier.issn0148-0545
dc.identifier.issue4en_US
dc.identifier.pmid17934927en_US
dc.identifier.scopus2-s2.0-35348845407en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage399en_US
dc.identifier.urihttps://doi.org/10.1080/01480540701522601
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19081
dc.identifier.volume30en_US
dc.identifier.wosWOS:000250448200008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofDrug And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBinaphthylen_US
dc.subjectCd(II) Complexen_US
dc.subjectCu(II) Complexen_US
dc.subjectGenotoxicityen_US
dc.subjectHuman Lymphocytesen_US
dc.subjectMicronucleusen_US
dc.subjectIn-Vitroen_US
dc.subjectMicronucleus Assayen_US
dc.subjectCrystal-Structureen_US
dc.subjectDnaen_US
dc.subjectCytotoxicityen_US
dc.subjectCoordinationen_US
dc.subjectNickel(Ii)en_US
dc.subjectInductionen_US
dc.subjectCellsen_US
dc.subjectDrugen_US
dc.titleSynthesis and characterization of a new macrocyclic ligand and its copper (II), cadmium (II), and lead (II) complexesen_US
dc.typeArticleen_US

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