Synthesis and characterization of a new macrocyclic ligand and its copper (II), cadmium (II), and lead (II) complexes
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A new macrocyclic ligand 1,1'-bis(bis-(6,6'-oxymethylenyl-2,2'-bipyridine) binaphthyl, (L), and its complexes CuL(ClO4)(2), CuL(NO3)(2,) 3H(2)O, CdL(ClO4)(2), and PbL(ClO4)(2) have been synthesized and characterized on the basis of IR, H-1 NMR, C-13 NMR, FAB mass, and elemental analyses. Genotoxicity of these metal complexes has also been investigated by cytokinesis- blocked micronucleus assay in cultured human lymphocytes. Blood cultures were set up from two healthy donors, and treatment was done with different test concentrations for 24 and 48 h. The current results indicate that all compounds caused cytotoxicity by decreasing the cell number at the 150 mu g/mL doses for 48-h treatments. On the other hand, CuL(ClO4)(2), CuL(NO3)(2,) 3H(2)O and PbL(ClO4)(2) exhibited genotoxicity by inducing the number of micronucleated cells at doses of 150 mu g/mL for 24-h treatments, but CdL(ClO4)(2) did not significantly alter micronucleus induction. Hence, some test compounds may act as mutagens or produce clastogenic effects depending upon their chemical structures.
Açıklama
Anahtar Kelimeler
Binaphthyl, Cd(II) Complex, Cu(II) Complex, Genotoxicity, Human Lymphocytes, Micronucleus, In-Vitro, Micronucleus Assay, Crystal-Structure, Dna, Cytotoxicity, Coordination, Nickel(Ii), Induction, Cells, Drug
Kaynak
Drug And Chemical Toxicology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
30
Sayı
4
