The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney

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dc.authoridPalabıyık, Orkide/0000-0002-3488-3740
dc.authoridUlucam, Enis/0000-0002-4686-7350
dc.authorid, Aziz KARACA/0000-0001-9408-5073
dc.authoridvardar, selma arzu/0000-0002-1073-1718
dc.authorwosidYılmaz, Ali/KLZ-9798-2024
dc.authorwosidPalabıyık, Orkide/Q-2792-2019
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidUluçam, Enis/HQZ-3831-2023
dc.authorwosidUlucam, Enis/AAG-9204-2019
dc.contributor.authorTastekin, Ebru
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorUlucam, Enis
dc.contributor.authorUzgur, Selda
dc.contributor.authorKaraca, Aziz
dc.contributor.authorVardar, Selma Arzu
dc.contributor.authorYilmaz, Ali
dc.date.accessioned2024-06-12T11:01:35Z
dc.date.available2024-06-12T11:01:35Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractLong-term effects of high protein diets (HPDs) on kidneys are still not sufficiently studied. Irisin which increases oxygen consumption and thermogenesis in white fat cells was shown in skeletal muscles and many tissues. Nitric oxide synthases (NOS) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. We aimed to investigate the effects of HPD, irisin and NO expression in kidney and relation of them with exercise and among themselves. Animals were grouped as control, exercise, HPD and exercise combined with HPD (exercise-HPD). Rats were kept on a HPD for 5 weeks and an exercise program was given them as 5 exercise and 2 rest days per week exercising on a treadmill with increasing speed and angle. In our study, while HPD group had similar total antioxidant capacity (TAC) levels with control group, exercise and exercise-HPD groups had lower levels (p<0.05). Kidneys of exercising rats had no change in irisin or eNOS expression but their iNOS expression had increased (p<0.001). HPD-E group has not been observed to cause kidney damage and not have a significant effect on rat kidney irisin, eNOS, or iNOS expression. Localization of irisin, eNOS, and iNOS staining in kidney is highly selective and quite clear in this study. Effects of exercise and HPD on kidney should be evaluated with different exercise protocols and contents of the diet. risin, eNOS, and iNOS staining localizations should be supported with various research studies.en_US
dc.identifier.doi10.1080/0886022X.2016.1194163
dc.identifier.endpage1114en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7en_US
dc.identifier.pmid27277302en_US
dc.identifier.scopus2-s2.0-84973643434en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1107en_US
dc.identifier.urihttps://doi.org/10.1080/0886022X.2016.1194163
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20954
dc.identifier.volume38en_US
dc.identifier.wosWOS:000382175000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExerciseen_US
dc.subjectHigh Protein Dieten_US
dc.subjectIrisinen_US
dc.subjectNitric Oxideen_US
dc.subjectEnosen_US
dc.subjectInosen_US
dc.subjectSkeletal-Muscleen_US
dc.subjectNitric-Oxideen_US
dc.subjectCirculating Irisinen_US
dc.subjectBody-Compositionen_US
dc.subjectSerum Irisinen_US
dc.subjectWeight-Lossen_US
dc.subjectBrown-Faten_US
dc.subjectObeseen_US
dc.subjectAdultsen_US
dc.subjectThermogenesisen_US
dc.titleThe effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidneyen_US
dc.typeArticleen_US

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