The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Long-term effects of high protein diets (HPDs) on kidneys are still not sufficiently studied. Irisin which increases oxygen consumption and thermogenesis in white fat cells was shown in skeletal muscles and many tissues. Nitric oxide synthases (NOS) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. We aimed to investigate the effects of HPD, irisin and NO expression in kidney and relation of them with exercise and among themselves. Animals were grouped as control, exercise, HPD and exercise combined with HPD (exercise-HPD). Rats were kept on a HPD for 5 weeks and an exercise program was given them as 5 exercise and 2 rest days per week exercising on a treadmill with increasing speed and angle. In our study, while HPD group had similar total antioxidant capacity (TAC) levels with control group, exercise and exercise-HPD groups had lower levels (p<0.05). Kidneys of exercising rats had no change in irisin or eNOS expression but their iNOS expression had increased (p<0.001). HPD-E group has not been observed to cause kidney damage and not have a significant effect on rat kidney irisin, eNOS, or iNOS expression. Localization of irisin, eNOS, and iNOS staining in kidney is highly selective and quite clear in this study. Effects of exercise and HPD on kidney should be evaluated with different exercise protocols and contents of the diet. risin, eNOS, and iNOS staining localizations should be supported with various research studies.
Açıklama
Anahtar Kelimeler
Exercise, High Protein Diet, Irisin, Nitric Oxide, Enos, Inos, Skeletal-Muscle, Nitric-Oxide, Circulating Irisin, Body-Composition, Serum Irisin, Weight-Loss, Brown-Fat, Obese, Adults, Thermogenesis
Kaynak
Renal Failure
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
38
Sayı
7
