Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives

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dc.authoridGoger, Gamze/0000-0003-2978-5385
dc.authoridGöger, Fatih/0000-0002-9665-0256
dc.authoridDemirci, Fatih/0000-0003-1497-3017
dc.authorwosidGoger, Gamze/JCE-6911-2023
dc.authorwosidGöger, Fatih/HTR-3454-2023
dc.authorwosidDemirci, Fatih/A-8295-2008
dc.contributor.authorTay, Naime Funda
dc.contributor.authorDuran, Murat
dc.contributor.authorKayagil, Ismail
dc.contributor.authorYurttas, Leyla
dc.contributor.authorGoger, Gamze
dc.contributor.authorGoger, Fatih
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2024-06-12T11:16:41Z
dc.date.available2024-06-12T11:16:41Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 mu g/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.en_US
dc.description.sponsorshipScientific Research Projects Fund of Eskisehir Osmangazi University [201119002]; Eskisehir Osmangazi Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Fund of Eskisehir Osmangazi University by the project number: 201119002. The authors gratefully acknowledge the financial support by Eskisehir Osmangazi University.en_US
dc.identifier.doi10.1590/s2175-97902022e191026
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85129728009en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/s2175-97902022e191026
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24402
dc.identifier.volume58en_US
dc.identifier.wosWOS:000828470900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal Of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTriazoleen_US
dc.subjectThiazoleen_US
dc.subjectPyridineen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectDPPH Radical Scavengingen_US
dc.subject1,2,4-Triazole Derivativesen_US
dc.subjectBiological Evaluationen_US
dc.subjectIn-Vitroen_US
dc.subjectMolecular Dockingen_US
dc.subjectHybrid Moleculesen_US
dc.subjectLinked Bisen_US
dc.subjectAntifungalen_US
dc.subjectAntitumoren_US
dc.subjectAntibacterialen_US
dc.subjectAgentsen_US
dc.titleSynthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivativesen_US
dc.typeArticleen_US

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