Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Sao Paulo, Conjunto Quimicas
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 mu g/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.
Açıklama
Anahtar Kelimeler
Triazole, Thiazole, Pyridine, Antimicrobial Activity, Antioxidant Activity, DPPH Radical Scavenging, 1,2,4-Triazole Derivatives, Biological Evaluation, In-Vitro, Molecular Docking, Hybrid Molecules, Linked Bis, Antifungal, Antitumor, Antibacterial, Agents
Kaynak
Brazilian Journal Of Pharmaceutical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
58
