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    The effects of angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C gene polymorphisms on the development of diabetic nephropathy in type 2 diabetes mellitus patients
    (Aepress Sro, 2023) Yukcu, Fulya; Sipahi, Tammam; Guldiken, Sibel; Ustundag, Sedat; Sut, Necdet
    AIMS: Diabetic nephropathy is one of the major complications of Type 2 diabetes mellitus. In this study, we aimed to investigate the effects of angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C gene polymorphisms on the development of diabetic nephropathy in patients with type 2 diabetes mellitus. METHODS: This study included 100 type 2 diabetes mellitus patients with diabetic nephropathy patients (patient group) and 99 type 2 diabetes mellitus patients without diabetic nephropathy (control group). Polymerase chain reaction and restriction fragment length polymorphism methods were used to identify polymorphisms in the angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C genes.RESULTS: There was no significant difference in genotype frequencies of M235T gene polymorphism between patient and control groups (chi 2 = 4.01, df = 2, p = 0.13). There was no significant difference in genotype frequencies of T174M gene polymorphism between patient and control groups (X2 = 0.36, df = 2, p = 0.83). There was no significant difference in genotype frequencies of A1166C gene polymorphism between patient and control groups (chi 2 = 0.51, df = 2, p = 0.77).CONCLUSIONS: The results showed no significant difference in angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C gene polymorphisms between the patient and control groups. Future studies are needed to validate the results of this study and to explore underlying mechanisms (Tab. 3, Fig. 3, Ref. 35). Text in PDF www.elis.sk
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    Relationship Between an Osteoprotegerin Gene Polymorphism and Diabetic Vascular Complications
    (Clin Lab Publ, 2015) Soysal-Atile, Neslihan; Guldiken, Sibel; Sipahi, Tammam; Yukcu, Fulya; Ekiz-Bilir, Betul; Huseyin, Serhat; Ege, Turan
    Background: Osteoprotegerin (OPG), which was recently identified as a vascular marker, is increased in patients with diabetes mellitus (DM). This study evaluated the frequency of the OPG gene single nucleotide A163G polymorphism and its association with diabetic microvascular and macrovascular complications. Methods: The A163G polymorphism of the OPG gene was assessed in the peripheral blood of 116 patients with type 2 DM and 107 healthy subjects by polymerase chain reaction and restriction fragment length polymorphism. Microvascular and macrovascular complications were evaluated in diabetic patients. Results: Statistical analysis showed no significant difference in distribution of the OPG A163G polymorphism in the diabetic and control groups. Similarly, this polymorphism was not associated with microvascular or macrovascular complications. Conclusions: This OPG polymorphism does not play a role in the development of microvascular and macrovascular complications in patients with DM.