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Öğe Arterial distensibility in Wegener's granulomatosis(Turkish Soc Cardiology, 2007) Yildiz, Mustafa; Soy, Mehmet; Kueruem, Turhan; Yildiz, Banu SahinObjective: The purpose of this study was to test the hypothesis; that chronic inflammation may impair vascular function and lead to an increase of arterial pulse wave velocity (PWV) in patients with Wegener's granulomatosis (WG). Methods: We recruited 5 patients with WG and 5 healthy age and sex matched controls in this cross-sectional case-controlled study. Aortic PWV was determined by using an automatic device (Complior Colson, France), which allowed on-line pulse wave recording and automatic calculation of PWV. Results: The carotid-femoral (aortic) PWV was increased in patients with WG as compared with control group (p=0.04). Although we found positive correlation between MAN and heart rate (r=0.75, p=0.01), we did not find any significant correlation between PWV and anthropometric and other hemodynamic parameters (p>0.05). In addition, we found positive correlation between PWV and erythrocyte sedimentation rate in patients with WG (r=0.90, p=0.03). Conclusion: Pulse wave velocity is increased and arterial distensibility decreased in patients with WG. Measurements of carotid-femoral (aortic) PWV may provide an easy and noninvasive technique to identify patients at increased risk of arterial disease.Öğe Assessment of arterial distensibility in patients with cardiac syndrome x(Sage Publications Inc, 2007) Yildiz, Mustafa; Altun, Armagan; Ozbay, GultacThis study aims to investigate arterial distensibility by using carotid-femoral (aortic) pulse wave velocity measurements in Patients with cardiac syndrome X. The authors studied 10 patients with cardiac syndrome X (mean age 49.4 +/- 7.5, 39 to 67 years old, 3 men) and 10 healthy subjects (mean age 50.0 +/- 10.5, 38 to 70 years old, 3 men). Carotid-femoral pulse wave velocity measured by a Complior Colson device was calculated for each patient. The carotid-femoral pulse wave velocity was increased in patients with cardiac syndrome X as compared with age-matched control subjects (10.25 +/- 1.28 vs 8.95 +/- 0.89 m/s, p=0.01). In contrast, there were no significant differences in the age, weight, height, body mass index, waist/hip ratio, systolic blood pressure, diastolic blood pressure, mean blood pressure, pulse pressure, and heart rate (P=0.76, p=0.17, p=0.36, p=0.08, p=0.21, p=0.14, p=0.89, p=0.30, P=0.10, p = 0.36, respectively). No significant correlation was found between pulse wave velocity and age, sex, height, weight, heart rate, systolic blood pressure, diastolic blood pressure, mean blood pressure, and pulse pressure in the studied groups (p > 0.05). The arterial distensibility was decreased in patients with cardiac syndrome X. The deterioration in these patients showed that this disease might be a more generalized disturbance of the vasculature. Measurements of carotid-femoral pulse wave velocity may provide a simple and noninvasive technique to identify patients at increased risk of vascular disease.Öğe Association Between Matrix Metalloproteinase-9 C-1562T Gene Polymorphism and Ischemic Stroke(Galenos Publ House, 2023) Kara, Ismail; Sipahi, Tammam; Sunal, Asli Sert; Yildiz, Mustafa; Guldiken, BaburhanObjective: Matrix metalloproteinases (MMPs) are calcium-dependent zinc-containing proteases containing more than 28 enzymes that cause the degrading of the extracellular matrix. Although MMPs play key roles in many biological processes, they influence some pathological processes such as ischemic stroke (IS). Among MMPs, the enzyme most associated with IS is the MMP9 enzyme. This study aimed to evaluate the effect of the C-1562T (rs3918242) gene polymorphism of MMP9 on the development of IS in Turkish patients living in the Trakya Region.Materials and Methods: Our study involved 60 patients with IS and 60 controls. The patients with IS were categorized according to the Trial of ORG 10172 in Acute Stroke Treatment classification of stroke subtypes, and MMP9 C-1652T gene polymorphism was identified using polymerase chain reaction, followed by restriction fragment length polymorphism using the Pael (SphI) restriction enzyme.Results: Genotypes were defined as CC, CT, and TT according to the presence of C and T alleles. No significant differences were identified in the genotype distribution and allele frequency of MMP9 C-1562T gene polymorphism between the patients with IS and controls.Conclusion: Our findings suggest that MMP9 C-1562T gene polymorphism is not associated with the risk of IS in Turkish patients living in the Trakya Region.Öğe A comparative histopathological and immunohistochemical study of Survivin and Ki-67 proteins in glial tumours(Taylor & Francis Ltd, 2019) Topyalin, Nur; Budak, Metin; Ozbay, Nurver; Yildiz, Mustafa; Kaner, Tuncay; Aydin, Abdullah; Gezen, Ahmet FerruhSurvivin is a bifunctional protein which regulates cell division and inhibits apoptosis. Survivin is a member of the inhibitor of apoptosis protein (IAP) family. Expression of survivin has been shown to be responsible for apoptosis and resistance to ionizing radiation. The aim of the present study was to investigate the association between -31 G/C promoter polymorphism, survivin protein and glial tumour grading, and to compare survivin versus Ki-67 as a marker. In this study, DNA was isolated from paraffin-embedded sections of 29 patients diagnosed with glial tumours. Survivin gene promoter -31 G/C polymorphism was investigated using PCR-RFLP. For the analysis, 10 mu m sections were stained with survivin protein and Ki-67 antibody. Immunohistochemical staining was performed. Survivin showed a positive correlation with Ki-67 (r = 0.604; p = 0.001). The tumour grades correlated with survivin; however, the relationship was not statistically significant (r = 0.345; p > 0.05). We found a significant correlation between tumour grades and Ki-67 (r = 0.663; p < 0.01), suggesting that Ki-67 is a more sensitive marker compared to survivin.Öğe INCREASED ARTERIAL STIFFNESS MEASURED BY CAROTID FEMORAL (AORTIC) PULSE WAVE VELOCITY IN PATIENTS WITH INACTIVE BEHCET'S DISEASE(Russian Heart Failure Soc, 2020) Agus, Hicaz Zencirkiran; Yildiz, Banu Sahin; Kahraman, Serkan; Kalkan, Kubra; Aladag, Nazire Baskurt; Yildiz, MustafaIntroduction Behcet's disease (BD) is a chronic, multisystemic disease characterised by vascular involvement. Acute and chronic inflammatory processes associated with BD may cause endothelial dysfunction, which can then lead to a subsequent increase of arterial stiffness and altered pressure wave reflections. The aim of this study was to evaluate the pulse wave velocity (PWV) measurements in patients with inactive BD and control subjects. Methods We studied 50 patients with inactive BD and 49 healthy control subjects without known cardiovascular disease. Carotid-femoral PWV was determined in all subjects by the same expert research clinician using Complior device (Colson, Paris, France). Results Mean disease duration was 3.23 +/- 2.31 years. Patients with BD (mean age 36.04 +/- 9.94 years) had significantly higher PWV levels compared to controls (9.57 +/- 1.88 vs. 8.47 +/- 1.13 m/s; p=0,003). PWV was found to be positively correlated with age, systolic, diastolic, mean blood pressure, waist, and waist/hip ratio. Conclusion In our study we demonstrated that patients with BD exhibit significantly increased arterial stiffness assessed by increased carotid-femoral PWV compared to healthy control subjects.Öğe Investigation of acute effects of diclofenac sodium on rat kidney with unilateral ureteral obstruction(Elsevier Science Bv, 2008) Yildiz, Mustafa; Pekdemir, Murat; Akpolat, Nusret; Durukan, Polat; Seckin, Dilara; Celiker, Huseyin; Kavalci, CemilObjectives: Obstruction of urine passage in anywhere from kidney to urinary bladder is named as obstructive uropathy. It is seen in renal colic patients in emergency departments. Diclofenac sodium, a non-steroidal anti-inflammatory drug, is frequently used in the treatment. This study was designed to investigate acute effects of diclofenac sodium on the kidney with unilateral ureteral obstruction. Materials and Methods: The study was performed in Experimental Investigation Centre of Firat University Faculty of Medicine. Wistar type female rats were categorized as control (I), sham (II), diclofenac (DS) (III), unilateral uretheral obstruction (UUO) (IV) and UUO+DS (V) groups. Rats were anesthesized by ketamin (5 mg/kg) and xylazine (5 mg/kg). In the IInd, IVth and Vth groups, midline abdominal incision was performed and in the IVth and Vth groups urethers were binded unilaterally. One mg of DS was given to IIIrd, IVth and Vth groups. Kidneys were sacrified in all groups. Blood and tissue samples were taken for biochemical and pathological analysis. Results: There was significant difference between the groups in pathological evaluation regarding neutrophyl, lymphocyte, and macrophage infiltration and proximal tubular dilatation (p<0.01 for all). It was found that infiltration was particularly increased in UUO group but decreased in UUO+DS group. In the biochemical analysis, there was a significant difference between the groups in respect to plasma levels of PGE(2) (p<0.01) and TXA(2) (p<0.01). When control and UUO+DS groups were compared, plasma PGE(2) (p<0.01) and TXA(2) (p<0.01) levels were found to be significanlty decreased in UUO+DS group. Conclusion: As a result, in UUO rat group in the first 5 hour, DS decreased the inflammation and tubular dilatation; but neither positive nor negative tissue level effect was determined.Öğe Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification(Mdpi, 2019) Ozkan, Ugur; Ozcelik, Fatih; Yildiz, Mustafa; Budak, MetinCalcific aortic valve disease (CAVD) is a multifactorial condition. Both environmental and genetic factors play an important role in its etiology. CAVD exhibits a broad spectrum, varying from mild valve thickening to severe valve calcification and stenosis. Progression of the disease consists of chronic inflammation, lipoprotein deposition, and active leaflet calcification. It is a process similar to coronary artery disease. In this study, we investigated Lp(a) levels and gene polymorphisms associated with calcific aortic stenosis from blood samples after echocardiography in the evaluation of 75 patients diagnosed with CAVD and 77 controls. Blood tests were run in our laboratory to rule out certain risk factors before echocardiography examination. A significant association among smoking, elevated LDL level and creatinine, low albumin levels, Lp(a) level, rs10455872, and rs3798220 polymorphisms may be considered genetic risk factors for the development of calcific aortic stenosis.Öğe Susceptibility to Atherosclerosis in Patients with Psoriasis and Psoriatic Arthritis as Determined by Carotid-Femoral (Aortic) Pulse-Wave Velocity Measurement(Ediciones Doyma S A, 2009) Soy, Mehmet; Yildiz, Mustafa; Uyanik, Mehmet Sevki; Karaca, Nuran; Guefer, Goekhan; Piskin, SueleymanIntroduction and objectives. In this study we analyzed the susceptibility to atherosclerosis of patients with psoriasis and psoriatic arthritis (PsA) by determining the femoral-carotid pulse wave velocity (PWV), which is a measure of the viscoelastic properties of blood vessels. Methods. The study included 25 patients with psoriasis (age 18-63 years; 13 male), of whom nine had arthritis, as well as 39 sex- and age-matched healthy control subjects (age 24-70 years, 25 male). The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, body mass index (BMI) and waist-to-hip ratio (WHR) of all participants were recorded and, in patients, skin lesions were assessed using the psoriasis area and severity index (PASI). Arterial distensibility was determined by automatic carotid-femoral PWV measurement using the Complior Colson device. Results. Mean PWV, SBP and DBP were significantly higher in psoriatic patients than in control subjects (P=.036, P<.001, and P=.005, respectively). In PsA patients, the mean WHR, SBP, DBP and PWV were all significantly higher than in control subjects (P=.001, P=.031, P=.001, and P=.014, respectively). Conclusions. The carotid-femoral PWV is increased in patients with psoriasis and PsA.
