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Öğe Apical pouches with hypertrophic cardiomyopathy(Turkish Soc Cardiology, 2014) Ucar, Fatih Mehmet; Ozeke, Ozcan; Topaloglu, Serkan; Golbasi, Zehra[Abstract Not Available]Öğe The Association between Platelet/Lymphocyte Ratio and Coronary Artery Disease Severity in Asymptomatic Low Ejection Fraction Patients(Korean Soc Cardiology, 2016) Ucar, Fatih Mehmet; Acar, Burak; Gul, Murat; Ozeke, Ozcan; Aydogdu, SinanBackground and Objectives: Coronary angiography (CAG) is generally needed in the setting of systolic heart failure (HF) with an unidentified etiology as a part of diagnostic strategy. On the other hand, the clinical value of this invasive strategy is largely unknown. Platelet-lymphocyte ratio (PLR) has recently emerged as a novel inflammatory index that may serve as an important predictor of inflammatory state and overall mortality. The present study aimed to search the predictive value of PLR in determining the extent of coronary atherosclerosis in asymptomatic low ejection fraction (EF) patients. Subjects and Methods: 156 asymptomatic heart failure (HF) subjects (without angina or HF symptoms, mean age: 58 years; to male: 71.2% were enrolled, and thereafter a CAG was performed. Gensini Score was used to determine the severity of coronary artery disease (CAD) on CAG. According to this scoring system, the overall study group was categorized into three distinct subgroups: control group with the score 0, mild atherosclerosis group with the score 0 to 20 and severe atherosclerosis group with the score of >20. Thereafter, a comparison was made among groups with regard to mean values of PLR. Results:The severe atherosclerosis group had a substantially higher level of mean PLR in comparison to other groups (p<0.001). Pre-CAG PLR levels as well as a variety of clinical variables including age, low density lipoprotein (LDL)-cholesterol demonstrated an independent correlation with Gensini score through a multivariate analysis. Conclusion: These findings suggest the potential association of high PLR levels with severe atherosclerosis in the setting of asymptomatic systolic HF. A simple measurement of PLR helps to identify the severity of coronary atherosclerosis prior to conducting coronary angiography.Öğe Evaluation of Index of Cardioelectrophysiological Balance (iCEB) in Patients with Rheumatoid Arthritis(Aves, 2018) Ucar, Fatih Mehmet; Yilmaztepe, Mustafa Adem; Taylan, GokayObjective: Index of cardioelectrophysiological balance (iCEB), measured as QT interval divided by QRS duration, is defined recently as a new risk marker for arrhythmias. Increased or decreased iCEB is associated with malignant ventricular arrhythmias. We aimed to investigate the ventricular balance between the depolarization (changes in QRS duration) and depolarization (changes in the QT interval) of the cardiac action potential in rheumatoid arthritis (RA) patients by using iCEB. Materials and Methods: In total, 60 patients (mean age was 49.4 +/- 11.7 y and 61% of the patients were female) with RA and 60 control subjects (45.3 +/- 12.6 y and 60% of the patients were female) were enrolled. iCEB (QT/QRS) and iCEBc (heart rate-corrected QT (QTc)/QRS) rates were calculated from the 12-lead electrocardiogram. Results: iCEB and iCEBc were significantly higher in patients with RA than in control subjects (p<0.001 and p<0.001, respectively), and they were correlated with high-sensitivity C-reactive protein (hsCRP) levels (r=0.467, p<0.001 and r=0.479, p<0.001, respectively) Conclusions: Our results indicate that iCEB was increased in patients with RA. It is known that high iCEB is associated with torsade de Pointes (TdP) ventricular tachycardia. The increased frequency of ventricular arrhythmias in patients with RA may be TdP-related and can be clarified by the new index of balance between depolarization and repolarization (iCEB).Öğe Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with acute myocarditis(Bmc, 2019) Ucar, Fatih Mehmet; Ozturk, Cihan; Yilmaztepe, Mustafa AdemBackground Acute myocarditis (AM) can be defined as an inflammatory disease of the myocardium and characterized by large heterogeneity of clinical presentation. Myocarditis is becoming increasingly recognized as a contributor to unexplained mortality, and is thought to be a major cause of sudden cardiac death in the first two decades of life. The present study aimed to search the assessment of repolarization dispersion measured from the 12-lead surface electrocardiogram (including Tp-e interval, Tp-e/QT and Tp-e/QTc ratios) in AM patients. Methods Totally 56 patients (mean age was 22 +/- 3.7 years and 67% of the patients were male) with AM and 56 control subjects (23 +/- 4.7 years and 64% of the patients were male) were enrolled. Tp-e intervals, Tp-e/QT and Tp-e/corrected QT (QTc) ratios were calculated from 12-lead electrocardiogram. Results Heart rate, QT and QTc values were similar between groups. QRS interval was lower in AM group compared to the control group (p < 0.001). Tp-e, Tp-e/QT and Tp-e/ QTc were significantly higher in AM group (p < 0.001, p < 0.001, p = 0.03 respectively) and they were significantly correlated with high troponin and high sensitive C reactive protein levels. In hospital follow-up time was 6 +/- 2 days. Four patients have non sustained ventricular tachyarrhythmias and 1 patient dead because of cardiac arrest. Conclusions Our study demonstrated that Tp-e intervals, Tp-e/QT and Tp-e/QTc ratios were higher in patients with AM than control subjects. The increased frequency of ventricular arrhythmias can be clarified by increased indexes of ventricular repolarization parameters in patients with AM.Öğe Gamma-glutamyl transferase predicts recurrences of atrial fibrillation after catheter ablation(Taylor & Francis Ltd, 2016) Ucar, Fatih Mehmet; Ipek, Esra Gucuk; Acar, Burak; Gul, Murat; Tuncez, Abdullah; Ozeke, Ozcan; Geyik, BilalBackground Catheter ablation is a popular therapy of atrial fibrillation (AF). Gamma-glutamyl transferase (GGT) is known as a marker of oxidative stress. The objective of this study was to ascertain the relationship between levels of GGT and recurrence of AF after catheter ablation. Methods A total of 102 paroxysmal AF patients who underwent cryoballoon catheter ablation were enrolled. Serum samples were obtained to evaluate GGT levels before catheter ablation. Cox regression analysis was used to estimate the predictors of AF recurrence. Results Mean age of the cohort was 49.9 +/- 11.7 and 63% of the patients were male. After a mean follow-up of 20 months, 19 (23%) patients had AF recurrences. The baseline GGT levels were significantly higher in patients who had AF recurrence [27 U/L (17-36) vs 18 U/L (13-22), P=0.0021.The optimal cut-off value of GGT to predict AF recurrence was 23.5 U/L according to receiver operating characteristic curve analysis (area under the curve 0.72, P=0.002). In the multivariable Cox regression analysis, baseline GGT > 23.5 was the only independent predictor of AF recurrence (hazard ratio (HR) 4.47, 95% confidence interval [1.66-12.09], P=0.003). Conclusions Our results indicate that elevated GGT is associated with AF recurrence. A simple measurement of GGT may help us to identify high-risk patients undergoing catheter ablation for AF.Öğe ICD Detected Non Sustained Ventricular Tachycardia Episodes are Associated with Hospitalization(Excerpta Medica Inc-Elsevier Science Inc, 2017) Ucar, Fatih Mehmet; Yilmaztepe, Mustafa Adem; Taylan, Gokay; Aktoz, Meryem[Abstract Not Available]Öğe ICD Detected Patient Activity is Associated with Arrhythmic Events in Heart Failure Patients [Meeting Abstract](Excerpta Medica Inc-Elsevier Science Inc, 2017) Ucar, Fatih Mehmet; Yilmaztepe, Mustafa Adem[Abstract Not Available]Öğe The Importance and Safety of Contrast Venography before Procedure in Patients with Permanent(Excerpta Medica Inc-Elsevier Science Inc, 2017) Ucar, Fatih Mehmet; Yilmaztepe, Mustafa Adem[Abstract Not Available]Öğe Intermittent Atrioventricular Block After An Automobile Accident(Excerpta Medica Inc-Elsevier Science Inc, 2017) Ucar, Fatih Mehmet[Abstract Not Available]Öğe Layer-specific strain analysis in patients with suspected stable angina pectoris and apparently normal left ventricular wall motion(BMC, 2018) Yilmaztepe, Mustafa Adem; Ucar, Fatih MehmetBackground: Non-invasive imaging tests are widely used in the evaluation of stable angina pectoris (SAP). Despite these tests, non-significant coronary lesions are not a rare finding in patients undergoing elective coronary angiography (CAG). Two-dimensional (2D) speckle tracking global longitudinal strain (GLS) imaging is a more sensitive and accurate technique for measuring LV function than conventional 2D methods. Layer-specific strain analysis is a relatively new method that provides endocardial and epicardial myocardial layer assessment. The aim of the present study was to evaluate longitudinal layer-specific strain (LSS) imaging in patients with suspected SAP. Methods: Patients who underwent CAG for SAP were retrospectively screened. A total of 79 patients with no history of heart disease and wall motion abnormalities were included in the study. Forty-three patients with coronary lesions > 70% constituted the coronary artery disease (CAD) group and 36 patients without significant CAD constituted the control group. Layer-specific GLS transmural, endocardium, and epicardium values (GLS-trans, GLS-endo, and GLS-epi, respectively) were compared between the groups. Results: Patients in the CAD group had significantly lower GLS values in all layers (GLS-trans: -18.2 + 2.4% vs -22.2 + 2.2% p <.001; GLS-endo: -20.8 + 2.8% vs -25.3 + 2.6%, p < .001; GLS-epi: 15.9 + 2.4% vs -19.5 + 1.9%, p < .001). Multivariate adjustment demonstrated GLS-trans as the only independent predictor of CAD (OR:0.472, CI (0.326-0.684), p < .001]. Additionally, the GLS values were all lower in myocardial perfusion scintigraphy (MPS) true-positive patients compared with MPS false-positive patients (GLS-trans: -17.7 +/- 2.4 vs. -21.9 +/- 2.4%, p < .001; GLS-endo: -20.2 +/- 2.9% vs -24.9 +/- 2.9%, P < .001; GLS-epi: 15.4 +/- 2.6% vs. -19.2 +/- 1.8%, P < .001). Conclusion: Resting layer-specific strain as assessed by 2D speckle tracking analysis demonstrated that GLS values were reduced in all layers of myocardium with SAP and with no wall motion abnormalities. LSS analysis can improve the identification of patients with significant CAD but further prospective larger scale studies are needed to put forth the incremental value of LSS analysis over transmural GLS.Öğe Lead extraction and contrast venography(Turkish Soc Cardiology, 2018) Ucar, Fatih Mehmet[Abstract Not Available]Öğe Left ventricle pseudoaneurysm detected eight months after myocardial infarction(Turkish Soc Cardiology, 2019) Yilmaztepe, Mustafa Adem; Ozturk, Cihan; Ucar, Fatih Mehmet; Kaya, Caglar; Gurdogan, Muhammet[Abstract Not Available]Öğe Mobitz type II, 2:1 atrioventricular block mimicking as a convulsive seizure(Turkish Soc Cardiology, 2019) Kaya, Caglar; Zeybey, Utku; Akpinar, Meliha; Taylan, Gokay; Ucar, Fatih Mehmet[Abstract Not Available]Öğe Non-Sustained Ventricular Tachycardia Episodes Predict Future Hospitalization in ICD Recipients with Heart Failure(Arquivos Brasileiros Cardiologia, 2017) Ucar, Fatih Mehmet; Yilmaztepe, Mustafa Adem; Taylan, Gokay; Aktoz, MeryemBackground: Implantable cardioverter-defibrillator (ICD) therapy is well known to reduce mortality in selected patients with heart failure (HF). Objective: To investigate whether monitored episodes of non-sustained ventricular tachycardia (NSVT) might predict future HF hospitalizations in ICD recipients with HF. Methods: We examined 104 ICD recipients (mean age: 60 +/- 10.1 years, 80.8 % male) with HF who were referred to our outpatient clinic for device follow-up. After device interrogation, patients were divided into NSVT positive and negative groups. The primary endpoint was the rate of hospitalization within the next 6 months after initial ICD evaluation. Results: Device evaluation demonstrated at least one episode of monitored NSVT in 50 out of 104 patients. As expected, no device therapy (shock or anti-tachycardia) was needed for such episodes. At 6 months, 24 patients were hospitalized due to acute decompensated HF. Hospitalization rate was significantly lower in the NSVT negative as compared with positive groups (38% versus 62%; adjusted hazard ratio [HR] 0.166 ; 95% CI 0.056 to 0.492; p = 0.01). Conclusions: Monitored NSVT bouts in ICD recordings may serve as a predictor of future HF hospitalizations in ICD recipients with HF suggesting optimization of therapeutic modalities in these patients along with a close supervision in the clinical setting.Öğe Periprocedural cardiac troponin elevation: a potential indicator of enhanced ventricular threshold in permanent pacemaker recipients.(Scientific Publishers India, 2017) Ucar, Fatih Mehmet; Taylan, Gokay; Yilmaztepe, Mustafa Adem; Aktoz, MeryemBackground and aim: Permanent cardiac pacing is the most efficient treatment for patients with symptomatic bradycardia and high-degree atrioventricular (AV) block. For effective pacing, sensing and pacemaker battery longevity; ventricular pacing threshold (VPT) levels, lead impedance levels and Rwave amplitude levels must be desirable. We aimed to search the association between elevated serum troponin levels and VPT values in patients who has implanted single chamber permanent pacemaker. Materials and methods: We retrospectively analyzed a total of 109 patients (mean age: 78 +/- 7.1 years, 53.6% male) who underwent single chamber permanent pacemaker implantation for indications such high-degree atrioventricular block and sick sinus syndrome. Hematological and biochemical parameters were measured prior to pacemaker implantation. Additionally troponin I and high-sensitivity C-reactive protein (hs-CRP) were sampled about 12 hours after pacemaker implantation. Results: Over a median follow-up period of 17.3 months, 32 (29.3%) patients has positive troponin I levels after implantation. Troponin positive group has higher VPT values at the time of implantation (0.94 +/- 0.33 vs. 0.71 +/- 0.19, p<0.001) and at 30th day of implantation (0.69 +/- 0.16 V vs. 0.91 +/- 0.31 V, p<0.001). To identify in dependent risk factors for ventricular threshold values, a multivariate linear regression model was conducted and after implantation having positive troponin value (beta= 0.337, p= 0.01) and troponin elevation ratio (beta= 0.365, p<0.001) were found to be independent risk factors for ventricular threshold. Conclusion: Our results indicate that troponin I elevation after pacemaker implantation is associated with higher VPT values at the time of and the 30th day of implantation. For longevity of pacemaker batteries, low threshold values are preferable. To further extend the life of pacemakers, we recommend following patients more closely who has high troponin levels after permanent pace replacement.Öğe Periprocedural Cardiac Troponin Elevation: A Potential Marker of Enhanced Ventricular Threshold in Permanent Pacemaker Recipients(Excerpta Medica Inc-Elsevier Science Inc, 2017) Ucar, Fatih Mehmet; Yilmaztepe, Mustafa Adem; Taylan, Gokay; Aktoz, Meryem[Abstract Not Available]Öğe A potential marker of bare metal stent restenosis: monocyte count - to- HDL cholesterol ratio(Biomed Central Ltd, 2016) Ucar, Fatih MehmetBackground: Oxidation and inflammation play significant roles in the pathogenesis of coronary artery diseases. Monocyte count to high-density lipoprotein (HDL) cholesterol ratio (MHR) is a new marker and has revealed as an indicator of inflammation in the literature. The present study aimed to search the effect of MHR on in-stent restenosis (ISR) in patients with stable or unstable angina pectoris undergoing bare-metal stent (BMS) implantation. Methods: A total of 468 consecutive stable or unstable angina pectoris patients (mean age 60.3 +/- 10.1 and 70 % men) who had undergone successful BMS implantation were included the study. Serum samples were obtained before the procedure. Results: The mean period between two coronary angiography procedures was 14 +/- 7.9 months. The baseline MHR levels were significantly higher in patients that had ISR (odds ratio, 3.64; 95 % confidence interval, 2.45-4.84; P < 0. 001). Stent diameter, the time between the two coronary angiographic studies, uric acid and MHR levels emerged as independent predictors of ISR. Conclusions: Our results indicate that elevated MHR is an independent and powerful predictor of ISR in patients with stable or unstable angina pectoris who underwent successful BMS implantation.Öğe Prominent Crista Terminal's in a Young Woman(Excerpta Medica Inc-Elsevier Science Inc, 2017) Ucar, Fatih Mehmet[Abstract Not Available]Öğe QRS narrowing and prediction of response to cardiac resynchronization therapy(Turkish Soc Cardiology, 2018) Ucar, Fatih Mehmet[Abstract Not Available]Öğe A Rare Case of Lead Revision With Subclavian Vein Stenosis: Transport Lead From Opposite Side to Generator.(Excerpta Medica Inc-Elsevier Science Inc, 2017) Ucar, Fatih Mehmet; Yilmaztepe, Mustafa Adem[Abstract Not Available]
