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Öğe APPLYING A NOVEL STATISTICAL METHOD TO DETERMINATION OF DISEASE-FREE SURVIVAL IN BREAST CANCER PATIENTS(Elsevier Ireland Ltd, 2008) Tokatli, F.; Ture, M.; Kurt, I.; Alas, R. Cosar; Uzal, C.[Abstract Not Available]Öğe A comparison of the effect on gastric emptying of propofol or dexmedetomidine in critically ill patients(Cambridge Univ Press, 2006) Memis, D.; Dokmeci, D.; Karamanlioglu, B.; Turan, A.; Ture, M.Background: Propofol and dexmedetomidine are widely used for sedation in the intensive care unit yet there are limited data on its effects on gastric motility. In our preliminary study, we examined whether or not any effect of propofol and dexmedetomidine on gastric emptying is preserved in critically ill patients. Methods: Twenty-four critically ill, enterally fed adult patients each received enteral feeding via a nasogastric tube at 50 mL h(-1) throughout the 5-h study period. Either propofol 2 mg kg(-1) h(-1) (n = 12, Group P) or dexmedetomidine 0.2 mu g kg(-1) h(-1) (n = 12, Group D) was given intravenously over 5h. Gastric motility was measured indirectly by analysis of the absorption over time of 1.5 g of paracetamol administered into the stomach at the start of the study period. At the beginning and end of the study, residual gastric volume and pH of residual gastric fluid were measured. Results: Gastric residual volume measured at the end of propofol infusion (19.33 +/- 11.33) was found to be higher when compared with the volume measured before infusion (11.33 +/- 4.84) and after dexmedetomidine infusion (9.17 +/- 4.54). But, there was no difference between groups in gastric emptying time (AUC120 894.53 +/- 499.39 vs. 1113.46 +/- 598-09 propofol and dexmedetomidine groups, respectively). Conclusion: In our study, gastric residual volume measured at the end of propofol infusion was found to be higher when compared with the volume measured before infusion and after dexmedetomidine infusion. There was no difference between groups in gastric emptying time.Öğe Gabapentin reduces cardiovascular responses to laryngoscopy and tracheal intubation(Lippincott Williams & Wilkins, 2006) Memis, D.; Turan, A.; Karamanlioglu, B.; Seker, S.; Ture, M.Background and objective: We have compared the effects of gabapentin on arterial pressure and heart rate at induction of anaesthesia and tracheal intubation in a randomized double-blind study. Methods: Ninety normotensive patients (ASA I) undergoing elective surgery were divided into three groups of 30 patients each. Patients received oral placebo (Group I), 400 mg of gabapentin (Group 11) or 800 mg of gabapentin (Group III) 1 h prior to surgery in, the operating theatre. After induction of anaesthesia heart rate and mean arterial pressure were recorded at baseline 1, 3, 5, 10 and 15 min after intubation. Results: Patients receiving placebo and 400 mg gabapentin showed a significant increase in blood pressure and heart rate associated with tracheal intubation compared to baseline levels and Group III. There was significant decrease in heart rate and arterial pressure in Group III after intubation 1, 3, 5 and 10 min (P < 0.001, P < 0.001, P < 0.05 and P < 0.05, respectively) compared to Groups I and II. Conclusion: Given 1 h before operation gabapentin 800 mg blunted the arterial pressure and heart rate increase in first 10min due to endotracheal intubation. Oral administration of gabapentin 800 mg before induction of anaesthesia is a simple and practical method for attenuating pressor response to laryngoscopy and tracheal intubation after standard elective induction.Öğe Prevalence of Allergic Rhinitis among Medical School Students in Edirne (Turkey) and the Impact of Symptoms on Quality of Life(Mosby-Elsevier, 2009) Yazicioglu, M.; Yildirim, S.; Celik, H.; Kaptan, B.; Teloren, B.; Aylanc, H.; Ture, M.[Abstract Not Available]
