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Öğe Association between serum total and lipid-bound sialic acid concentration and the severity of coronary atherosclerosis(Mosby-Elsevier, 2002) Gokmen, SS; Kilicli, G; Ozcelik, F; Ture, M; Gulen, SSerum total sialic acid has recently been shown to be a cardiovascular risk factor. Increased levels of this substance are associated with higher cardiovascular mortality and with cerebrovascular disease. It has also been shown that serum concentrations of total and lipid-associated sialic acid are significantly increased in hypertriglyceridemia. On the other hand, several circulating lipoproteins have been suggested to be related to the severity of coronary atherosclerosis, but contradictory results have been reported in the possible relationship between the concentrations of sialic acid and the severity of coronary lesions in patients with coronary heart disease. The purpose of this study was to investigate the possible relationship between serum total sialic acid concentration, recently shown to be a cardiovascular risk factor, and serum lipid-bound sialic acid concentration and the severity of coronary lesions. The study comprised 90 subjects, divided into three subgroups according to angiography results: 30 patients with no vessel disease, 30 patients with single-vessel disease, and 30 patients with double/triple-vessel disease. Serum total sialic acid determination was carried out with the thiobarbituric acid method of Warren; lipid-associated sialic acid was assayed with the method of Katopodis. Mean serum total sialic acid levels in patients with single-vessel disease (P <.05) and patients with double/triple-vessel disease (P <.001) were found to be significantly increased compared with that in patients with no vessel disease, whereas mean serum lipid-bound sialic acid levels were found to be significantly different between patients with double- or triple-vessel disease and patients with no vessel disease (P <.001). We also noted a significant difference between the levels of serum total sialic acid (P <.001) and lipid-bound sialic acid (P <.001) in patients with single-vessel disease and patients with double/triple-vessel disease. We found a significant correlation only between serum lipid-bound sialic acid and coronary angiographic score in patients with double/triple-vessel disease (r = 0.425, P <.05). Although the concentration of serum total sialic acid is increased proportionally with the number of diseased coronary arteries, only the concentration of serum lipid-bound sialic acid is related to the severity of coronary atherosclerosis, especially in patients with double/triple-vessel disease.Öğe Clastogenicity of selective serotonin-reuptake inhibitors(Elsevier Science Bv, 2004) Bozkurt, G; Abay, E; Ates, I; Karabogaz, G; Ture, M; Savran, FO; Palanduz, SObjective: Selective serotonin-reuptake inhibitors (SSRIs) are used in the treatment of various forms of psychiatric disorders. Preclinical studies in laboratory animals have indicated that SSRIs were not genotoxic, but clear results from in vitro testing of SSRIs in a human cell system are currently scarce. The purpose of this study was to investigate whether SSRIs might be genotoxic. Sertraline was chosen as model SSRI, since it appears to be at least as well-tolerated as other SSRIs and may even have a more favourable side-effect profile. Unlike fluoxetine, fluvoxamine and paroxetine, sertraline has low potential for pharmacokinetic drug interactions. So, sertraline would be considered first in the treatment of psychiatric disorders requiring SSRI therapy in the future. We therefore examined peripheral lymphocytes from sertraline-treated patients for both sister chromatid exchanges (SCEs), cells with a high frequency of SCEs (HFC) and chromosome aberrations (CA) to evaluate the elastogenicity of SSRIs. Method: Ten sertraline-treated patients meeting 'Structured Clinical Interview for DSM-IV' criteria for both generalized anxiety disorder and major depression were compared with 18 healthy volunteers and 18 non-treated patients with similar psychopathology. Sertraline hydrochloride was administered orally at 50 mg daily for 10 months to I year. The participants were selected on the basis of similar responses to a questionnaire assessing risk of genotoxicity related to other aspects of life. All participants had very similar lifestyles, medical histories, biological and dietary factors. All subjects were non-smokers. Result: A statistically significant difference between patients with both generalized anxiety disorder and major depression (sertraline-treated or non-treated) and healthy volunteer groups was found by both SCE frequencies and HFC percentages. Both patient groups showed higher frequencies of SCEs than the healthy controls. No statistically significant difference was found between SCE frequencies or HFC percentages observed in sertraline-treated and non-treated patient groups. No statistical difference was found between groups with respect to the frequency of CA. Conclusion: There are no adequate studies analysing the clastogenicity of SSRIs, in particular of sertraline. The SCE frequency, the percentage HFC and the frequency of CA in patients with both generalized anxiety disorder and major depression exposed to daily doses of sertraline do not indicate a possible clastogenic hazard. The increased SCE frequencies in patients with both generalized anxiety disorder and major depression in our study-irrespective of sertraline treatment-indicate a possible genotoxic effect. However, our observations were based on a limited number of patients; the results may be explained by psychogenic stress. (C) 2003 Elsevier B.V. All rights reserved.Öğe Comparing classification techniques for predicting essential hypertension(Pergamon-Elsevier Science Ltd, 2005) Ture, M; Kurt, I; Kurum, AT; Ozdamar, KHypertension is a leading cause of heart disease and stroke. In this study, performance of classification techniques is compared in order to predict the risk of essential hypertension disease. A retrospective analysis was performed in 694 subjects (452 patients and 242 controls). We compared performances of three decision trees, four statistical algorithms, and two neural networks. Predictor variables were age, sex, family history of hypertension, smoking habits, lipoprotein (a), triglyceride, uric acid, total cholesterol, and body mass index (BMI). Classification techniques were grouped using hierarchical cluster analysis (HCA). The data points appeared to cluster in three groups. The first cluster included MLP and RBF. Furthermore CART which was more similar than other techniques linked this cluster. The second cluster included FDA/MARS (degree= 1), LR and QUEST, but FDA/MARS (degree= 1) and LR was more similar than QUEST. The third cluster included FDA/MARS (degree =2), CHAID and FDA, but FDA/MARS (degree =2) and CHAID was more similar than FDA. MLP and RBF which are one each of neural networks procedures, performed better than other techniques in predicting hypertension. QUEST had a lesser performance than other techniques. (c) 2005 Elsevier Ltd. All rights reserved.Öğe Comparison of four different time series methods to forecast hepatitis A virus infection(Pergamon-Elsevier Science Ltd, 2006) Ture, M; Kurt, IHepatitis A virus (HAV) infection is not a problem of only developing countries, but also of developed countries. In this study, we compared time series prediction capabilities of three artificial neural networks (ANN) algorithms (multi-layer perceptron (MLP). radial basis function (RBF), and time delay neural networks (TDNN)), and auto-regressive integrated moving average (ARIMA) model to HAV forecasting. To assess the effectiveness of these methods, we used in forecasting 13 years of time series (January 1992-June 2004) monthly records for HAV data, in Turkey. Results show that MLP is more accurate and performs better than RBF, TDNN and ARIMA model. (c) 2005 Elsevier Ltd. All rights reserved.Öğe Effects of coffee consumption and smoking habit on bone mineral density(Springer Heidelberg, 2006) Demirbag, D; Ozdemir, F; Ture, MThis study aims to investigate how a person's smoking and coffee consumption habits in the premenopausal stage can affect the postmenopausal BMD values. Two hundred females in the postmenopause stage were evaluated. The average daily coffee consumption and smoking habits in the premenopause stage and the demographic characteristics, age and duration of menopause of all the cases were identified and noted. The bone mineral density (BMD) evaluations of these cases were made with Dual Energy X-ray Absorbsiometer (DEXA) technique. The relationship of the questioned risk factors with BMD and differences among the groups were investigated. No correlation was found between the amount of coffee consumption and BMD. The BMD values of the smokers' group were lower than non-smokers' group. As a result, advancing age, duration of menopause and smoking habits have been identified to be risk factors in relation to OP.Öğe Genotoxicity of waste anaesthetic gases(Australian Soc Anaesthetists, 2002) Bozkurt, G; Memis, D; Karabogaz, G; Pamukcu, Z; Ture, M; Karamanlioglu, B; Gunday, IBackground and aim: The possibility of a potential mutagenic or carcinogenic action of chronic exposure to low concentrations of inhalational anaesthetics has been previously studied, with conflicting results. The purpose of this study was to assess whether occupational exposure to waste anaesthetic gases increases genotoxic risk. We examined peripheral lymphocytes from anaesthetists for both sister chromatid exchange (SCE) and for cells with high-frequency SCEs (HFCs). Method: A group of 16 non-smoking anaesthetists with occupational exposure to anaesthetic gases and a sex- and age-matched group matched 16 non-smoking matched physicians without occupational exposure to anaesthetic gases were studied. The participants were also selected on the basis of similar responses to a questionnaire assessing risk of genotoxicity relating to other aspects of life. Result: SCEs, and HFC percentages obtained from the exposed anaesthetists (6.6 +/- 2.4 and 12.2 +/- 15.9) were greater but not statistically significantly so than in the reference group (5.2 +/- 1.6 and 5.9 +/- 10.0). Conclusion: This study does not support the existence of an association between occupational exposure to waste anaesthetic gases and an increase in SCEs in lymphocytes. The nature of our anaesthesia practice suggests exposure was likely to be low. It should be noted that some anaesthetic gases produce lesions that can be efficiently repaired in mitogen-stimulated lymphocytes in vitro but not in circulating lymphocytes.Öğe Indoor airborne fungal spores and home characteristics in asthmatic children from Edirne region of Turkey(Mosby, Inc, 2002) Yazicioglu, M; Asan, A; Önes, Ü; Vatansever, U; Sen, B; Ture, M; Bostancioglu, M[Abstract Not Available]Öğe Infiltration with ropivacaine plus lornoxicam reduces postoperative pain and opioid consumption(Springer, 2005) Karamanlioglu, B; Turan, A; Memis, D; Kaya, G; Ozata, S; Ture, MPurpose: To compare efficacy and patient outcome of wound infiltration with ropivacaine, lornoxicam, or their combination for control of pain following thyroid surgery. Methods: Eighty patients underwent thyroid surgery were randomly assigned to one of four groups. Before skin closure, local tissues were infiltrated with 12 mL saline in Group S, with 10 mL of ropivacaine 0.75% plus 2 mL saline in Group R, with 2 mL of lornoxicam (8 mg) plus 10 mL saline in Group L, and with 10 mL ropivacaine 0.75% plus 2 mL lornoxicam (8 mg) in Group RL. Pain scores, total and incremental meperidine consumption were recorded at 30 min, one, two, three, four, six, eight, 12, 18, and 24 hr postoperatively. Time to first analgesic requirement, patient satisfaction, and duration of hospital stay were also compared after surgery. Results: The pain scores in Group RL were significantly lower in the first 12 hr than in Group S, and in the first four hours than in Groups R and L (P<0.01). The time to first analgesic requirement was significantly longer (14.8 +/- 8.4 hr vs 5.9 +/- 5.2 hr; P<0.0 1), the total pethidine consumption was significantly less than Group S (34.0 +/- 33.0 mg vs 78.0 +/- 29.8 mg; P<0.001), return of gastrointestinal function, ambulation time, length of hospital stay (P<0.05) were significantly shorter, and patient satisfaction (P<0.01) was significantly better in Group RL than in Group S (P<0.05). Conclusion: Wound infiltration with ropivacaine 0.75% plus lornoxicam 8 mg combination improved postoperative pain control and patient comfort, and decreased the need for opioids than the use of either drug alone.Öğe Inhibition of iNOS with S-methylisothiourea was impaired in wound heating in caustic esophageal burn(Elsevier Ireland Ltd, 2005) Basaran, UN; Eskiocak, S; Altaner, S; Ture, M; Yapar, SBObjective: Stricture formation is a late complication of caustic esophageal burn, which is a common problem in childhood. For this reason, this experimental study was designed to observe the possible effect of nitric oxide on heating and fibrosis formation in caustic esophageal burns. Materials and methods: The rats were divided into five groups. Group A (n = 12) received sham burn and treatment with saline injection. Group B (n = 34) received caustic burn. Rats in group C (n = 31), were given water supplement with 10 g/L L-arginine that was started 24 In preoperatively and continued until postoperative day 4. In group D (n = 21), S-methylisothiourea (SMT, specific inducible nitric oxide synthase (iNOS) inhibitor), was injected at a dose of 3 mg/kg i.p. at 30 min before caustic burn, and similar dose was reinjected immediatety after caustic burn. SMT 6 mg/kg/day injections continued for 4 days Long. In group E (n = 22), N omega-nitro-L-arginine (L-NNA, nonspecific nitric oxide synthase (NOS) inhibitor) was injected at a dose of 15 mg/kg i.p. at 30 min before caustic burn, and similar dose was reinjected immediately after caustic burn. L-NNA 30 mg/kg/day continues for 4 days. Results: Dead rates were significantly higher in group Ethan in groups A-D. The mean hydroxyproline levels in esophageal. tissue were significantly lower in groups A and B than in group D. Histopathologically, tissue damage scores in the esophageal tissue were higher in group D than in groups A-C. Conclusions: Inhibition of iNOS with SMT was impaired in wound heating due to caustic esophageal burn and provoked collagen accumulation at a later period. Those effects may due to inhibition of antioxidant, immunomodulatory and antifibrotic effects of NO. (c) 2004 Elsevier Ireland Ltd. All rights reserved.Öğe Monitoring indoor airborne fungi and bacteria in the different areas of Trakya University Hospital, Edirne, Turkey(Sage Publications Ltd, 2002) Sarica, S; Asan, A; Otkun, MT; Ture, MThe aim of this investigation was to monitor monthly the densities and distribution of indoor airborne fungi and bacteria in 6 different areas of Trakya University Hospital (Edirne, Turkey). Areas monitored were an operating theatre, birthing-room, emergency department, service area for infectious diseases, intensive care unit and the canteen. Our method was to expose Petri dishes which contained rose-bengal streptomycin agar and 5% sheep-blood agar media to room air for 10-min periods. Samples were collected at 1-month intervals from September 2000 to February 2001. A total of 156 microfungal and 535 bacterial colonies were counted on 144 plates. During a 6-month period, 10 bacterial genera (Acinetobacter, Bacillus, Corynebacterium, Enterococcus, Escherichia, Listeria, Micrococcus, Propionibacteria, Staphylococcus and Streptococcus)7 fungal genera (Altemaria, Aspergillus, Cladosporium, Paecilomyces, Penicillium, Scopulariopsis and Trichothecium) and 33 fungal species were isolated from the hospital air. Penicillium loliense, P. melinii and P. phoeniceum were newly recognised species for Turkey. Some bacterial species such as coagulase-negative Staphylococcus, Micrococcus and Corynebacterium spp. were predominant (percentages of colonies counted were 72.2, 10.7 and 8.8%, respectively). Cladosporium and Penicillium were the most prevalent fungal genera. Cladosporium was predominant in September, November and February, Alternaria in October and December and Penicillium in January. Staphylococcus spp. was the most common bacterial species in all months. Statistical analyses (regression with optimal scaling test) were applied to the data.Öğe Monitoring of fungi and bacteria in the indoor air of primary schools in Edirne city, Turkey(Sage Publications Ltd, 2005) Aydogdu, H; Asan, A; Otkun, MT; Ture, MWe monitored levels of bacteria and fungi in the indoor air at selected sites of several public primary schools in the city of Edirne, Turkey. Sampling was by the Petri plate method onto both a Rose-Bengal streptomycin agar medium and a 5% sheep-blood agar medium exposed to the air for 10-minute periods. Samples were collected monthly over a period of 6 months between August 2001 and January 2002. A total of 941 microfungi and 2066 bacterial colonies were counted on 90 Petri plates. During this 6-month period, 19 bacterial genera, 15 fungal genera and 48 species of fungi were isolated from the air in the schools. Some bacteria, such as coagulase-negative Staphylococcus, Corynebacterium and Bacillus, were predominant (42.7%, 20.4% and 6.9% of the total, respectively). Penicillium, Cladosporium and Alternaria were the most common fungal genera (42.8%, 19.3% and 10.1% of the total, respectively). Staphylococcus, Acinetobacter, Corynebacterium, Propionibacterium and Pseudo-monas genera were found in every month. Statistical analysis of the data showed a positive correlation between the concentrations of bacteria and air humidity (p = 0.002, R-2 = 0.726) and between bacterial concentrations and age of the schools (p=0.045, R-2 = 0.787). Also, that there was seasonal variation since the concentrations of fungi and bacteria varied according to the months (p = 0.001).Öğe Patterns of single segment non-physeal extremity fractures in children(Springer Verlag, 1999) Aktas, S; Saridogan, K; Moralar, U; Ture, MFive hundred and fifteen children with single segment non-physeal extremity fractures were retrospectively reviewed, The male to female ratio was 2.7:1. The average age of study group was 9.9+/-4.7 years; 273 fractures (53 %) were on the left, 242 (47 %) were on the right. A fall was the main cause of the injury in most of the cases (80%). The forearm was the most commonly seen fracture site. Summer was the season when the fracture incidence was the highest. Highest surgical treatment rate (50%) was seen in supracondylar humerus fractures. It has been stated in the literature that non-physeal fractures are far more common than physeal fractures, We assume that this study not only will help understanding of the injury patterns of single segment :non-physeal fractures in children but also, be a base for future studies in prevention and treatment of this type of fracture.Öğe The potential cardioprotective effects of amifostine in irradiated rats(Elsevier Science Inc, 2004) Tokatli, F; Uzal, C; Doganay, L; Kocak, Z; Kaya, M; Ture, M; Kurum, TPurpose: The aim of this study is to determine the cardioprotective efficacy of amifostine. The study consists of researching the relationship between plasma brain natriuretic peptide levels and the electrical and morphologic changes in irradiated rats with or without amifostine. Methods and Materials: Sixty Wistar albino rats were divided into 4 groups, and their hearts were given 15 Gy/fraction with Co-60. In Groups I and II, the rats were killed after 24 hours to detect early effects; in Groups III and IV, the rats were killed 100 days after irradiation to detect late effects. Before irradiation, Groups I and III received 0.9% saline solution, whereas Groups II and IV received amifostine (200 mg/kg). Twenty rats were used as a control group. Results: On the 100th day, mild myocardial degeneration was detected in 5 rats (33%) from Group III (no amifostine). This percentage was statistically different from that of Group IV (treated with amifostine) and the controls (p = 0.042). There was no statistically significant difference between the mean plasma brain natriuretic peptide values of the groups (p > 0.05). There was no significant difference in electrocardiographies between the groups. There was no correlation between continuous variables. Conclusion: In the amifostine group (IV) on the 100th day, there was no myocardial degeneration, suggesting that amifostine has a cardioprotective effect. (C) 2004 Elsevier Inc.Öğe The relationship between Tc-99m MIBI uptake and chemotherapeutic response, metastasis, Pgp, p53, and prognosis in lung cancer(Springer-Verlag, 2001) Yüksel, M; Çermik, TF; Doganay, L; Karlikaya, C; Salan, A; Çakir, E; Ture, M[Abstract Not Available]Öğe Sequential pulmonary effects of radiotherapy detected by functional and radiological end points in women with breast cancer(Elsevier Science London, 2005) Tokatli, F; Kaya, M; Kocak, Z; Ture, M; Mert, S; Unlu, E; Alkaya, FAims: To determine the pulmonary effects of locoregional irradiation on clinical and sub-clinical radiographic and functional end points in women with breast cancer, and whether the course of these end points is affected by laterality. Materials and methods: Twenty patients (10 irradiated on the left side and 10 irradiated on the right side) were prospectively evaluated for changes in pulmonary function tests, Tc-99m DTPA (diethylenetriamine pentaacetic acid) lung clearance scintigraphy and high-resolution computed tomography (HRCT) at 6, 16 and 52 weeks after radiotherapy. Tc-99m DTPA clearance, expressed as the biological half-time, T (1/2), was computed from the time-activity curves for 10 min for each lung. The irradiated lung volume was calculated for each patient. Results: The mean irradiated lung volume was 6.4% +/- 2 (range 3-11 %) for the entire population. In the whole study population, two (10%) patients, who were irradiated on the left side, had mild symptomatic radiation pneumonitis in the follow-up period. There was a statistically significant gradual reduction in all pulmonary function test values during the follow-up period. For patients irradiated on the left side, Tc-99m DTPA clearance T-1/2 values were statistically significantly decreased during the follow-up period (P = 0.03), but the decrease was not statistically significant for patients irradiated on the right side (P = 0.62). Tc-99m DTPA clearance T-1/2 values were statistically significantly decreased in the irradiated lung compared with the opposite lung, and no improvement was seen at week 52 after radiotherapy. The number of patients with changes on HRCT scans increased after radiotherapy, reaching a maximum at 16 weeks, when 80% of patients had changes. There was subsequent partial recovery 52 weeks after radiotherapy. Conclusion: Locoregional irradiation for breast cancer may cause sub-clinical irreversible impairment of radiological and functional pulmonary parameters. The increase in clearance rate of Tc-99m DTPA may be more prominent for patients with left-sided breast cancer. Tokatli, F. et al. (2005). (C) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.Öğe Tl-201 uptake and its relationship with chemotherapeutic response, metastasis, p53 status, and survival in primary lung cancer(Springer-Verlag, 2001) Çermik, TF; Yüksel, M; Karlikaya, C; Doganay, L; Çakir, E; Salan, A; Ture, M[Abstract Not Available]
