Genotoxicity of waste anaesthetic gases
Küçük Resim Yok
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Australian Soc Anaesthetists
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background and aim: The possibility of a potential mutagenic or carcinogenic action of chronic exposure to low concentrations of inhalational anaesthetics has been previously studied, with conflicting results. The purpose of this study was to assess whether occupational exposure to waste anaesthetic gases increases genotoxic risk. We examined peripheral lymphocytes from anaesthetists for both sister chromatid exchange (SCE) and for cells with high-frequency SCEs (HFCs). Method: A group of 16 non-smoking anaesthetists with occupational exposure to anaesthetic gases and a sex- and age-matched group matched 16 non-smoking matched physicians without occupational exposure to anaesthetic gases were studied. The participants were also selected on the basis of similar responses to a questionnaire assessing risk of genotoxicity relating to other aspects of life. Result: SCEs, and HFC percentages obtained from the exposed anaesthetists (6.6 +/- 2.4 and 12.2 +/- 15.9) were greater but not statistically significantly so than in the reference group (5.2 +/- 1.6 and 5.9 +/- 10.0). Conclusion: This study does not support the existence of an association between occupational exposure to waste anaesthetic gases and an increase in SCEs in lymphocytes. The nature of our anaesthesia practice suggests exposure was likely to be low. It should be noted that some anaesthetic gases produce lesions that can be efficiently repaired in mitogen-stimulated lymphocytes in vitro but not in circulating lymphocytes.
Açıklama
Anahtar Kelimeler
Anaesthetic Gases : Trace Concentrations Anaesthetic Volatile : Atmospheric Pollution, Anaesthetist : Risks, Genotoxicity, Sister-Chromatid Exchange, Operating-Room Personnel, Oxide-Exposed Primates, Ethylene-Oxide, Nitrous-Oxide, Cytogenetic Damage, Frequency Cells, Lymphocytes, Mutagenicity, Anesthetics
Kaynak
Anaesthesia And Intensive Care
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
30
Sayı
5
