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Öğe 99mTc-dimercaptosuccinic acid scan versus MRI in pyelonephritis: a meta-analysis(Lippincott Williams & Wilkins, 2020) Sarikaya, Ismet; Albatineh, Ahmed N.; Sarikaya, AliPurpose Tc-99m-dimercaptosuccinic acid (DMSA) scan is the current gold standard in detecting parenchymal changes, particularly scarring, in pyelonephritis. Recently, magnetic resonance imaging (MRI) is gaining popularity in the diagnosis of pyelonephritis. The aim of this study is to perform a meta-analysis on studies directly comparing MRI to DMSA scan in patients with pyelonephritis. Materials Systematic searches of PUBMED and EMBASE databases were performed to extract studies comparing MRI and DMSA scan in patients with pyelonephritis. The relevance of articles was assessed by two authors according to predefined inclusion and exclusion criteria. The pooled estimates of the sensitivities of MRI and DMSA scan were computed using random-effects meta-analysis model following DerSimonian and Laird's method. Subgroup analysis and publication bias were performed. Results Seven studies were included (164 patients). Using random effect model, the pooled estimate of the sensitivities of MRI and DMSA scan were 0.62 (95%CI: 0.44 - 0.77) and 0.59 (95%CI: 0.48 - 0.70), respectively. The pooled estimates of sensitivities of MRI and DMSA scan for acute pyelonephritis were 0.73 (95%CI: 0.49- 0.89) and 0.66 (95%CI: 0.56 - 0.75), respectively, and for scar detection were 0.48 (95%CI: 0.31- 0.66), and 0.50 (95%CI: 0.30 - 0.71), respectively. Conclusion The overall sensitivities of MRI and DMSA scan were equivalent in detecting parenchymal changes in pyelonephritis. MRI and DMSA scan appeared to be equivalent to scar detection. In a small number of studies, MRI appeared to be better than the DMSA scan in acute pyelonephritis but this should be further studied in a larger number of patients.Öğe Anemia and PET imaging(Springer-Verlag Italia Srl, 2021) Sarikaya, Ismet; Baqer, Ali; Sarikaya, AliAim Anemia is a blood disorder characterized by reduced Hemoglobin concentration and/or red blood cells numbers. Most common causes of anemia are iron deficiency anemia and anemia of chronic disease (anemia of chronic inflammation), but there is a long list of conditions which cause anemia. Bone marrow (BM), spleen, and liver are the main organs but various other tissues are also involved depending on the type of anemia. In this article, we aimed to review the role of PET imaging in anemia. Methods Normal BM, typical and atypical forms of hematopoiesis, pathogenesis of various forms of anemia, and PET findings in anemia with various radiotracers such as F-18-fluorodeoxyglucose, F-18-fluorothymidine, Fe-52 compounds and F-18-sodium fluoride were reviewed. Results In cases with anemia PET can help in determining the extent of BM expansion, distribution of BM, detecting proliferative activity of BM and BM islands in acellular BM on iliac biopsy, guiding BM biopsies, detecting typical or atypical extramedullary hematopoiesis, acute BM infarctions and various other complications such as osteomyelitis, cerebral infarction and infarction in various other tissues. Anemia-related PET findings can mimic tumor/metastases. Conclusion PET imaging is useful for assessing various types of anemia. It is also important to be aware of anemia-related PET findings to avoid mistaking them for malignancy or metastases.Öğe Anemia and PET imaging (Aug, 10.1007/s40336-021-00442-z, 2021)(Springer-Verlag Italia Srl, 2021) Sarikaya, Ismet; Baqer, Ali; Sarikaya, Ali[Abstract Not Available]Öğe Assessing 18F-FDG Uptake in the Sentinel Lymph Node in Breast Cancer(Soc Nuclear Medicine Inc, 2019) Sarikaya, Ismet; Sarikaya, AliF-18-FDG PET/CT has limited value in early breast cancer. Sentinel lymph node (SLN) biopsy is the current procedure of choice to search for small metastatic deposits in the axillary lymph nodes in early breast cancer. In this retrospective study, we reevaluated F-18-FDG PET/CT images after locating the SLN on PET/CT with the help of SLN SPECT/CT images and assessed F-18-FDG uptake, particularly in the SLN. Our goal was to understand if combined evaluation of F-18-FDG PET/CT and SLN SPECT/CT could be useful for detecting early lymph node metastasis in the axilla. Methods: F-18-FDG PET/CT images of newly diagnosed breast cancer patients who also had SLN scintigraphy (SPECT/CT) and biopsy results were analyzed to assess F-18-FDG uptake in the SLN. The SLN seen on SPECT/CT images was located on PET/CT images, and its metabolic activity was assessed both visually and semiquantitatively using SUVmax. F-18-FDG PET results were compared with the histopathology result for the SLN. Results: Twenty patients among 130 met the inclusion criteria. SLN SPECT/CT images were helpful for locating the SLN on F-18-FDG PET/CT images in all 20 patients. Histopathologic analysis of the SLNs demonstrated metastasis in 7 patients and no metastasis in 13. There was mild (visible) F-18-FDG uptake in the SLN (SUVmax, 1.2-4.1; metastatic deposit size, 68 mm) in 6 of 7 patients with SLN metastasis (85.7%). There was no or only faint F-18-FDG uptake in the SLN (SUVmax, 1) in 9 of 13 patients with no SLN metastasis (69.2%). Receiver-operating-characteristic curve analysis indicated that the SUVmax cutoff for differentiating SLN-positive from -negative cases was 0.85 (sensitivity, 85.7%; specificity, 61.5%; area under the curve, 0.747; P < 0.05). Conclusion: Combined evaluation of F-18-FDG PET/CT and SPECT/CT images to assess F-18-FDG uptake, particularly in the SLN, is a new image analysis technique to detect early metastatic disease in the axillary lymph nodes in breast cancer. Although this technique does not currently seem feasible for use in routine practice, mainly because of the limitations of current PET/CT technology in detecting small tumors, it is an interesting image analysis technique to be aware of for possible future use.Öğe Assessing oral glucose and intravenous insulin loading protocol in18F-fluorodeoxyglucose positron emission tomography cardiac viability studies(Wolters Kluwer Medknow Publications, 2020) Sarikaya, Ismet; Sharma, Prem N.; Sarikaya, Ali; Elgazzar, Abdelhamid H.Oral glucose and intravenous insulin (G/I) loading protocols are commonly used in18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) cardiac viability studies. Although the amount of insulin to be given per blood glucose range has been well described in guidelines, the amount of glucose to be given is not detailed well. In this retrospective study, we aimed to assess if certain parameters, particularly the amount of glucose and insulin given, may affect18F-FDG uptake in the hibernating myocardium and also determine the problems with this protocol.18F-FDG PET cardiac viability study with G/I loading protocols was performed in 49 patients. Fasting blood glucose (FBG), amount of glucose given, blood glucose level after glucose load, amount of insulin given, and blood glucose level at the time of18F-FDG injection were recorded. Statistical analysis was performed to determine if there is any difference in the above values in PET viable and PET nonviable groups and also in subgroups assessing18F-FDG uptake also in normal myocardium. For G/I loading, we used our local protocol in 43 patients, and other protocols in six.18F-FDG PET showed viability in 31 patients, and it was negative for viability in 18. In 22 patients, mainly in PET viable group, there was varying degree of reduced18F-FDG uptake in normal myocardium. There was no significant difference in FBG, amount of glucose given, blood glucose level after glucose load, amount of insulin given, and blood glucose level at the time of18F-FDG injection in PET viable and PET nonviable groups and also in subgroups. The problems with G/I loading protocol included deciding on the amounts of glucose and insulin given, maximum amount of insulin to be given, handling diabetics, optimal time to measure blood glucose after insulin administration, and interpretation of findings in cases with diffusely reduced18F-FDG uptake. Further improvements in current guidelines are necessary to obtain images in optimal conditions for accurate results.Öğe Assessing PET Parameters in Oncologic 18F-FDG Studies(Soc Nuclear Medicine Inc, 2020) Sarikaya, Ismet; Sarikaya, AliPET imaging, particularly oncologic applications of F-18-FDG, has become a routine diagnostic study. To better describe malignancies, various PET parameters are used. In F-18-FDG PET studies, SUVmax is the most commonly used parameter to measure the metabolic activity of the tumor. In obese patients, SUV corrected by lean body mass (SUL), and in pediatric patients, SUV corrected by body surface area, are recommended. Metabolic tumor volume is an important parameter to determine the local and total tumor burden. Total lesion glycolysis (SUVmean x metabolic tumor volume) provides information about averages. Some treatment response assessment protocols recommend using the SUVpeak or SULpeak of the tumor. Tumor-to-liver ratio and tumor-to-blood-pool ratio are helpful when comparing studies for treatment response assessment. Dual-time-point PET imaging with retention index can help differentiate malignant from benign lesions and may help detect small lesions. Dynamic F-18-FDG PET imaging and quantitative analysis can measure the metabolic, phosphorylation, and dephosphorylation rates of lesions but are mainly used for research purposes. In this article, we will review the currently available PET parameters in F-18-FDG studies with their importance, uses, limitations, and reasons for erroneous results.Öğe Assessing the Correlation Between 68Ga-PSMA-11 Renal PET Parameters and Renal Function Tests(Soc Nuclear Medicine Inc, 2022) Schierz, Jan-Henning; Sarikaya, Ismet; Albatineh, Ahmed N.; Sarikaya, AliGa-68-prostate-specific membrane antigen (PSMA) ligands are used for prostate cancer but also show high renal cortical uptake. In this study, we aimed to assess whether there is any correlation between renal PSMA PET parameters and renal function tests using the images of prostate cancer patients. Methods: (68)GaPSMA-11 PET/CT images of the patients with prostate cancer were retrospectively evaluated. The following PET parameters were obtained: SUVmax, SUVmean, SUVmax corrected for lean body weight, SUVmean corrected for lean body weight, volume, lean body weight-corrected total lesion glycolysis (TLG(SUL)), and counts of both kidneys, as well as SUVmean of the liver, blood pool, and spleen. Total TLG(SUL), total volume, kidney-to-liver ratio, and kidney-to-blood pool ratio were calculated. Creatinine values were obtained, and glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease formula. Statistical analysis was performed to understand whether there is a correlation between the above parameters and renal function tests. Results: Twenty-five patients were included in this study. GFR was significantly and positively correlated and creatinine was significantly and negatively correlated with the ratios of renal SUV to liver SUV and renal SUV to blood pool SUV. GFR was marginally positively correlated with renal SUVmean corrected for lean body weight, and creatinine was marginally negatively correlated with total TLG(SUL). Total renal parenchymal volume was significantly and directly (positively) associated with GFR and significantly and inversely (negatively) associated with creatinine. Conclusion: Renal Ga-68-PSMA uptake appears to be correlated with renal function tests. Our method of measuring approximate renal parenchymal volume on PET images appears to be reliable.Öğe Assessing the correlation between FDG PET findings of IDC breast carcinoma and histopathology of coexisting ductal carcinoma in-situ(Via Medica, 2022) Sarikaya, Ismet; Sarikaya, Ali; Albatineh, Ahmed N.; Tastekin, Ebru; Sezer, Yavuz AtakanBackground: Ductal carcinoma in-situ (DCIS) often coexists with invasive ductal carcinoma (IDC) of the breast. DCIS is consid-ered as a non-obligate precursor of IDC when both coexist. F-18-fluorodeoxyglucose positron emission tomography/computed tomography ([F-18]FDG PET/CT) imaging is commonly used in the staging and follow-up assessment of breast cancer. In this study, we aimed to assess if there is any correlation between primary tumor PET and histopathology findings and histopatho-logical features of the coexisting DCIS. Material and methods: FDG PET/CT images and histopathology results of the patients with newly diagnosed breast cancer (IDC) with coexisting DCIS were analyzed in this retrospective study. The grade and size of the primary tumor and histopathological features of the coexisting DCIS (nuclear grade and architectural pattern) were obtained from the postoperative histopathology results. Maximum standardized uptake values (SUV: SUVmax and SULmax) of the primary tumor normalized by weight and lean body mass were measured. Statistical analysis was performed to assess the correlation between various parameters of IDC and DCIS. Results: This study included sixty-two (62) patients with IDC-DCIS. Primary tumor grade was significantly correlated and associated with the nuclear grade of the coexisting DCIS (polychoric correlation r = 0.736, and Fisher exact test, PV < 0.001, respectively). Primary tumor SUV was not correlated with the nuclear grade and architectural pattern of the coexisting DCIS (polyserial correlation r = 0.172, PV = 0.155, and Point Bi-Serial correlation r = -0.009, PV = 0.955, respectively). Median primary tumor size was marginally significantly different among DCIS nuclear grades but it was not significantly different in comedo and non-comedo cases (Kruskal-Wallis test PV = 0.053, and Mann-Whitney U test PV = 0.890, respectively). Conclusions: Primary tumor grade is correlated with the nuclear grade of the coexisting DCIS. SUV of primary tumor does not seem to be correlated with the histopathological features of coexisting DCIS (nuclear grade and architectural pattern) but this may be further studied in a larger number of patients.Öğe Assessing the Effect of Various Blood Glucose Levels on 18F-FDG Activity in the Brain, Liver, and Blood Pool(Soc Nuclear Medicine Inc, 2019) Sarikaya, Ismet; Sarikaya, Ali; Sharma, PremStudies have extensively analyzed the effect of hyperglycemia on F-18-FDG uptake in normal tissues and tumors. In this study, we measured SUV in the brain, liver, and blood pool in normoglycemia, hyperglycemia, and hypoglycemia to understand the effect of blood glucose on F-18-FDG uptake and to develop a formula to correct SUV. Methods: Whole-body F-18-FDG PET/CT images of adults were selected for analysis. Brain SUVmax, blood-pool SUVmean, and liver SUVmean were measured at blood glucose ranges of 61-70, 71-80, 81-90, 91-100, 101-110, 111-120, 121-130, 131-140, 141-150, 151-160, 161-170, 171-180, 181-190, 191-200, and 201 mg/dL and above. At each blood glucose range, 10 PET images were analyzed (total, 150). The mean (+/- SD) SUV of the brain, liver, and blood pool at each blood glucose range was calculated, and blood glucose and SUV curves were generated. Because brain and tumors show a high expression of glucose transporters 1 and 3, we generated an SUV correction formula based on percentage reduction in brain SUVmax with increasing blood glucose level. Results: Mean brain SUVmax gradually decreased with increasing blood glucose level, starting after a level of 110 mg/dL. The approximate percentage reduction in brain SUV max was 20%, 35%, 50%, 60%, and 65% at blood glucose ranges of 111-120, 121-140, 141-160, 161-200, and 201 mg/dL and above, respectively. In the formula we generated, measured SUV max is multiplied by a reduction factor of 1.25, 1.5, 2, 2.5, and 2.8 for the blood glucose ranges of 111-120, 121-140, 141-160, 161-200, and 201 mg/dL and above, respectively, to correct SUV. Brain SUV max did not differ between hypoglycemic and normoglycemic patients (P > 0.05). SUVmean in the blood pool and liver was lower in hypoglycemic patients (P < 0.05) and did not differ between hyperglycemic (P > 0.05) and normoglycemic patients. Conclusion: Hyperglycemia gradually reduces brain F-18-FDG uptake, starting after a blood glucose level of 110 mg/dL. Hyperglycemia does not affect F-18-FDG activity in the liver or blood pool. Hypoglycemia does not seem to affect brain F-18-FDG uptake but appears to reduce liver and blood-pool activity. The simple formula we generated can be used to correct SUV in hyperglycemic adults in selected cases.Öğe Assessment of biological and clinical aggressiveness of invasive ductal breast cancer using baseline 18F-FDG PET/CT-derived volumetric parameters(Lippincott Williams & Wilkins, 2018) Aktas, Gul Ege; Tastekin, Ebru; Sarikaya, AliObjectiveThe aim of this study was to evaluate the relationship of baseline fluorine-18-fluorodeoxyglucose PET/computed tomography (CT)-derived volumetric parameters for the primary tumor with clinicopathological risk factors and molecular subtypes in patients with invasive ductal breast carcinoma (IDBC).Patients and methodsWe evaluated 65 patients who underwent fluorine-18-fluorodeoxyglucose PET/CT for initial breast cancer staging. The association of maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis (TLG) with clinicopathological risk factors and molecular subtypes was investigated and the discriminative power of significant features was assessed.ResultsAll volumetric parameters were significantly higher for tumors measuring more than 2cm and with a Ki-67 index of at least 20. Estrogen receptor (ER) and progesterone receptor (PR)-negative (ER-/PR-), human epidermal growth factor receptor 2-positive (HER2+), and triple-negative tumors showed increased SUVmax. SUVmax and SUVmean were higher for triple-negative and HER2+ IDBC than for ER+/HER2- IDBC. Metabolic tumor volume and TLG showed no differences among subtypes. All volumetric parameters correlated with the clinical tumor size and the Ki-67 index; these correlations differed among the different subtypes. Patients with systemic metastases showed significantly higher TLG. Receiver operating characteristic analysis showed that SUVmax had the highest discriminative power for the different subtypes, whereas TLG had a statistically significant discriminative power for systemic metastasis.ConclusionSUV(max) may appropriately reflect the immunohistochemical characteristics of IDBC, whereas TLG is associated with clinical risk factors and systemic metastasis. Our preliminary findings suggesting different relationships between volumetric parameters and the clinical tumor size and the Ki-67 index for different subtypes require further evaluation.Öğe Can 68Ga-DOTA Peptides Be Potential Radiotracers for PET Imaging of the Spleen?(Soc Nuclear Medicine Inc, 2018) Sarikaya, Ismet; Elgazzar, Abdelhamid H.; Sarikaya, Ali; Alnafisi, Naheel; Alenezi, SaudOn radionuclide somatostatin receptor imaging studies, the spleen shows high physiologic uptake. Reducing the intensity of the image settings helps to better assess the distribution of radiotracer in the spleen. In our routine studies, we incidentally recognized that Ga-68-DOTANOC PET provides higher-resolution splenic images than In-111-octreotide SPECT. Autoradiography and immunohistochemistry studies have shown that somatostatin receptors are located mainly in the red pulp of the spleen. The distribution of Ga-68-DOTANOC in the spleen appears to correlate with the distribution of red pulp. In this article, we present Ga-68-DOTANOC PET/CT spleen images of our patients.Öğe Correction of differential renal function for asymmetric renal area ratio in unilateral hydronephrosis(Springer, 2015) Aktas, Gul Ege; Sarikaya, AliChildren with unilateral hydronephrosis are followed up with anteroposterior pelvic diameter (APD), hydronephrosis grade, mercaptoacetyltriglycine (MAG-3) drainage pattern and differential renal function (DRF). Indeterminate drainage preserved DRF in higher grades of hydronephrosis, in some situations, complicating the decision-making process. Due to an asymmetric renal area ratio, falsely negative DRF estimations can result in missed optimal surgery times. This study was designed to assess whether correcting the DRF estimation according to kidney area could reflect the clinical situation of a hydronephrotic kidney better than a classical DRF calculation, concurrently with the hydronephrosis grade, APD and MAG-3 drainage pattern. We reviewed the MAG-3, dimercaptosuccinic acid (DMSA) scans and ultrasonography (US) of 23 children (6 girls, 17 boys, mean age: 29 +/- A 50 months) with unilateral hydronephrosis. MAG-3 and DMSA scans were performed within 3 months (mean 25.4 +/- A 30.7 days). The closest US findings (mean 41.5 +/- A 28.2 days) were used. DMSA DRF estimations were obtained using the geometric mean method. Secondary calculations were performed to correct the counts (the total counts divided by the number of pixels in ROI) according to kidney area. The renogram patterns of patients were evaluated and separated into subgroups. The visual assessment of DMSA scans was noted and the hydronephrotic kidney was classified in comparison to the normal contralateral kidney's uptake. The correlations of the DRF values of classical and area-corrected methods with MAG-3 renogram patterns, the visual classification of DMSA scan, the hydronephrosis grade and the APD were assessed. DRF estimations of two methods were statistically different (p: 0.001). The categories of 12 hydronephrotic kidneys were changed. There were no correlations between classical DRF estimations and the hydronephrosis grade, APD, visual classification of the DMSA scan and uptake evaluation. The DRF distributions according to MAG-3 drainage patterns were not different. Area-corrected DRF estimations correlated with all: with an increasing hydronephrosis grade and APD, DRF estimations decreased and MAG-3 drainage patterns worsened. A decrease in DRF (< 45 %) was determined when APD was a parts per thousand yen10 mm. When APD was a parts per thousand yen26 mm, a reduction of DRF below 40 % was determined. Our results suggest that correcting DRF estimation for asymmetric renal area ratio in unilateral hydronephrosis can be more robust than the classical method, especially for higher grades of hydronephrotic kidneys, under equivocal circumstances.Öğe Current status of F-18-FDG PET brain imaging in patients with dementia(Soc Nuclear Medicine Inc, 2018) Sarikaya, Ismet; Sarikaya, Ali; Elgazzar, Abdelhamid H.F-18-FDG PET brain imaging is commonly used in the early detection and differential diagnosis of various subtypes of dementias.F- 18-FDG PET images are mainly evaluated visually, and semiquantitative analysis programs are also commonly used in many centers. However, visual and semiquantitative analysis carry certain limitations. Visual assessment is subjective and dependent on expertise. Commercially available semiquantitative analysis programs have certain limitations such as suboptimal selection of brain areas or erroneous uptake normalization procedures that may provide inaccurate results, and physicians reporting semiquantitative results should be aware of these. In this pictorial review article, we will discuss the current status of F-18-FDG PET brain imaging in patients with dementia and present figures and semiquantitative analysis results of various sub-types of dementias as well as certain artifacts seen on F-18-FDG PET brain imaging studies.Öğe Current Status of Radionuclide Renal Cortical Imaging in Pyelonephritis(Soc Nuclear Medicine Inc, 2019) Sarikaya, Ismet; Sarikaya, AliPyelonephritis is an infection of the kidneys that is seen more commonly in children than the adults. Tc-99(m)-dimercaptosuccinic acid (Tc-99m-DMSA) scanning is a radionuclide imaging study to detect renal scarring after acute pyelonephritis (a late Tc-99m-DMSA scan) and also helps to diagnose acute pyelonephritis in febrile urinary tract infections (an acute Tc-99m-DMSA scan). Planar imaging in multiple views (posterior and bilateral posterior oblique) is generally used. Pinhole imaging with a high-resolution-collimator magnification of each kidney allows detection of smaller cortical defects. SPECT is optional. SPECT/CT is not recommended in children because it has a higher radiation exposure than routine Tc-99m-DMSA scans. The main limitations of Tc-99m-DMSA scanning include a relatively long waiting time after radiotracer injection, a long acquisition time, and a high radiation dose, which is particularly important in repeated studies on children and with the limited spatial resolution of y-cameras. Tc-99m-glucoheptonate is an alternative radiotracer when (99m)TcDMSA is not available. Radiotracers for dynamic renal functional imaging can grossly assess the renal cortex in the first few minutes of imaging. Ga-68-prostate-specific membrane antigen ligand (Ga-68-PSMA ligand) PET has the ability to provide images of normal renal cortex and demonstrate renal cortical defects from cysts. In this article, we assess the current status of renal cortical imaging and present Ga-68-PSMA ligand PET images. Ga-68-PSMA ligand provides excellent renal cortical images, and studies should be done to compare Ga-68-PSMA ligand PET with (99)mTc-DMSA scanning in renal diseases, particularly in pyelonephritis.Öğe Diffusely Increased Splenic Fluorodeoxyglucose Uptake in Lung Cancer Patients(Bilimsel Tip Publishing House, 2017) Aktas, Gul Ege; Sarikaya, Ali; Demir, Selin SoyluogluOBJECTIVES: This study aimed to investigate the association of diffuse splenic F-18 fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) with tumor maximum standardized uptake value (SUVmax), presence of distant metastases, and hematological and inflammatory parameters. MATERIAL AND METHODS: Initial FDG PET/CT of 15 lung cancer patients with diffuse splenic FDG uptake were retrospectively analyzed (Group 1). Twelve patients who recently underwent FDG PET/CT for histopathologically proven lung cancer were enrolled as the control group (Group 2). All 27 patients had hematological data, including C-reactive protein (CRP) level, within 5 days before or after PET/CT. To determine SUVmax, the region of interests included the tumor, liver, spleen, and iliac crest. The possible associations between the spleen/liver (S/L) and bone marrow/liver (BM/L) ratios and tumor SUVmax, presence of metastasis, and hematological parameters were evaluated. RESULTS: The S/L ratio and hemoglobin (Hb) levels were different between the two groups (p=0.000 and 0.05, respectively). The number of patients with anemia were significantly higher in Group 1 than in Group 2 (p=0.02). Although mean Hb levels were different between the two groups, there was no correlation between Hb levels and S/L ratios. There was no significant difference between the two groups with respect to the numbers of patients who had an accompanying infection site. Only CRP levels were correlated with S/L ratios in Group 1 among various other parameters (r=0.559, p=0.05). CONCLUSION: Our results suggested that inflammation degree correlated with increased splenic FDG uptake in lung cancer patients and was enhanced by anemia. Systemic inflammation and anemia could be important causes of diffusely increased splenic FDG accumulation on PET/CT examinations of lung cancer patients.Öğe Ectopic and Eutopic Located Parathyroid Lesions: Do They Behave Differently? How Can We Monitor Them? What Should We Look for?(Erciyes Univ Sch Medicine, 2019) Korkmaz, Ulku; Sarikaya, AliObjective: Hyperparathyroidism (HPT) is a frequent endocrine disorder that progresses with an increase in the parathormone (PTH) synthesis and secretion from the chief cells in one or more glands. The common methods used in the imaging of parathyroid adenomas are the ultrasonography and Tc-99m sestamibi scintigraphy (MIBI) scintigraphy. We aimed to investigate the determining characteristics and availability of the MIBI scintigraphy technique in detecting eutopic and ectopic localized parathyroid adenomas. Materials and Methods: This is a retrospective study. A total of 59 patients diagnosed with primary HPT between 2002 and 2010 using parathyroid scintigraphy with Tc99m MIBI imaging and dual-phase dual-isotope technique, which was reported as parathyroid adenoma, were enrolled into this study. To determine the radiopharmaceutic retention, an early parathyroid-to-thyroid ratio (early PT/T), late parathyroid-to-thyroid ratio (late PT/T), early-to-late ratio (E/L), and the retention index (RI) were calculated. Results: The lesions were divided into two groups: ectopic (n=28) and eutopic (n=37). When biochemical parameters were compared, there was not any statistically significant difference in the physiological parameters excluding the PTH levels. We determined that the level of PTH is the only biochemical parameter that is directly associated with the positivity of MIBI. Moreover, our findings revealed that the E/L ratio is negatively correlated with Ca+2 and P, while the RI ratio exhibited a positive association with Ca+2 and P in the ectopic group. Conclusion: We concluded that the MIBI is currently the best imaging method to diagnose parathyroid adenomas. The ideal imaging protocol should include a combination of a single photon emission computerized tomography study that is not prolonged over 1 h with an early and late planar (15 min and 2 h, respectively) imaging.Öğe Ectopic Pelvic Kidney Mimicking Sacral Metastasis on Post-Therapy Iodine-131 Scan of a Thyroid Cancer Patient(Galenos Yayincilik, 2017) Demir, Selin Soyluoglu; Aktas, Gul Ege; Polat, Ahmet; Sarikaya, AliA 25-year-old woman had total thyroidectomy and iodine-131 ablation therapy for papillary thyroid carcinoma. Whole body imaging on the 7th day of therapeutic activity demonstrated radioiodine uptake in the remnant tissue and intense heterogeneous uptake at the sacral region prominently in the posterior image. Initial interpretation was suspicious for sacral metastasis. Technetium-99m-methylene diphosphonate bone scan demonstrated normal bone uptake and the absence of left kidney. On blood-pool phase of bone scan, the absence of left renal activity and an extra area of uptake in the sacral region suggestive of pelvic kidney were noticed. Magnetic resonance imaging scan confirmed the ectopic pelvic kidney overlying the sacrum.Öğe Effects of clinical reanalysis in dual energy X-ray absorptiometry reports(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2017) Tuna, Filiz; Yavuz, Selcuk; Kabayel, Derya Demirbag; Sarikaya, AliObjectives: This study aims to assess poor positioning rates of patients during X-ray and the accuracy of the analysis. Patients and methods: In this study, we reanalyzed 323 dual energy X-ray absorptiometry (DXA) reports, by evaluating the scan images for proper patient positioning and scan analysis. We reviewed reports, according to a checklist prepared considering the proposals of Watts and The International Society for Clinical Densitometry official positions for 2013 (which were the same as in 2015). At least two remaining vertebrae were used to derive new bone mineral density and new T-scores. Results: Positioning failures were found in 64.7% of the spine X-rays, 60.5% of the hip X-rays, and 83.9% of X-rays of both regions. A total of 112 (34.7%) spinal DXA images needed new T-score adjustments. T-scores and bone mineral density differed between the first reports and the clinician reanalysis (p<0.001). Conclusion: The error rate in DXA reports was higher than expected. Clinician analysis of DXA reports are important. To obtain a quality DXA report, all healthcare professionals should be trained and reminded about this topic.Öğe Effects of gender and age on the quantitative parameters of [99mTc]pertechnetate salivary gland scintigraphy in normal subjects(Lippincott Williams & Wilkins, 2006) Firat, Fatih; Çermik, Tevfik F.; Sarikaya, Ali; Berkarda, SakirAim To assess the effect of gender and age on [Tc-99m]pertechnetate salivary gland scintigraphy (SGS) in healthy subjects. Methods The study population consisted of 93 normal subjects (46 women, 47 men; age range 20-59 years). The subjects were categorized into eight (four female and four male) subgroups according to age decades. Dynamic SGS was performed after intravenous injection of 370 MBq [Tc-99m]pertechnetate. Anterior salivary gland images were acquired for 30 min. On the basis of the time-activity curves, three functional parameters were calculated for the parotid and submandibular salivary glands: (1) the first minute uptake ratio, (2) the maximum uptake ratio, and (3) the maximum secretion percentage. Results For women, all parotid and submandibular functional parameters had a peak in the fourth decade group. The comparison of four age groups in the female subjects showed significant differences, except for the third versus the fifth decades, at least for one parameter The number of significant differences was highest in the comparison between the second versus the fourth decades. Among men, the highest values for all parotid and submandibular parameters were in the second decade, except for the first minute uptake ratio in the submandibular gland. The number of parameters that were significantly different among the four age groups in men was lower than in women. The first minute uptake ratio of the submandibular gland had the most significant differences among the groups of male subjects. Conclusion Age and gender differences have a significant effect on salivary gland functions which is more apparent in women than in men.Öğe Evaluation of prefabrication of high-density porous polyethylene implants (HDPPIs) by pathology, microangiography and bone scintigraphy(Soc Nuclear Medicine Inc, 2009) Top, Husamettin; Sarikaya, Ali; Benlier, Erol; Yalcin, Omer; Unal, Yasin; Aygit, Cemal[Abstract Not Available]
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