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Öğe Comparison with clearance of Tc-99m DTPA aerosol, and CO diffusing capacity, and lung function test in house painters(Springer-Verlag, 2001) Kaya, M; Salan, A; Tabakoglu, E; Aydogdu, N; Yüksel, M; Salihoglu, YS; Yigitbas, ON[Abstract Not Available]Öğe Evaluating the effect of halothan and the protective effect of catechine on liver parenchym with hepatobiliary scintigraphy(Springer-Verlag, 2001) Yuksel, M; Karamanloglu, B; Temiz, E; Salihoglu, YS[Abstract Not Available]Öğe Evaluation of liver parenchimal damage after pringle manoeuvre and protective effect of DMSO using hepatobiliary scintigraphy(Springer Verlag, 1999) Yüksel, M; Hatipoglu, A; Temiz, E; Salihoglu, YS; Hüseyinova, G; Berkarda, S[Abstract Not Available]Öğe Extensive bone metastases in a patient with prostatic adenocarcinoma and normal serum prostate-specific antigen and prostatic acid phosphatase(Lippincott Williams & Wilkins, 2001) Yuksel, M; Çermik, TF; Kaya, M; Salan, A; Ustun, F; Salihoglu, YS; Yigitbasi, ÖN[Abstract Not Available]Öğe Hepatobiliary scintigraphy for evaluating the hepatotoxic effect of halothane and the protective effect of catechin in comparison with histo-chemical analysis of liver tissue(Lippincott Williams & Wilkins, 2002) Karamanlioglu, B; Yüksel, M; Temiz, E; Salihoglu, YS; Çiftçi, SHalothane and its metabolites cause liver damage by decreasing liver blood flow and generating free-radical species. Catechin suppresses lipid peroxidation and increases enzyme activity, therefore it seems to be capable of protecting liver parenchyma against tine direct toxic effect of halothane. The aim of this study was to investigate the role of hepatobiliary scintigraphy in detecting liver damage after halothane anaesthesia and the protective effect of catechin in comparison with histo-chemical analysis. Thirty rabbits, divided into three groups (A, controls; B, halothane; and C, catechin+halothane), were investigated. In group A no anaesthesia was administered. Group B only received halothane, while group C was pretreated with catechin and halothane anaesthesia was administered for 2 h. Dynamic scintigrams were taken for 60 min after injecting Tc-99m-mebrofenin, and the time of peak uptake (TPU) and the time for half of the activity to clear from the liver (T-1/2) were calculated. Rabbits were killed, and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) levels were measured in hepatic tissue. The TPU and T-1/2 values of group A is significantly lower than in groups B and C (P < 0.0002 and P < 0.0002, respectively, for TPU; and P < 0.0002 and P < 0.0003, respectively, for T-1/2). The TPU and T-1/2 values of group B were significantly higher than in group C (P < 0.0003 and P < 0.0003, respectively). The hepatic MDA level of group A was significantly lower than in groups B and C (P < 0.0002 and P < 0.0002, respectively). SOD, GSH-Px and CAT levels of group A were significantly higher than in groups B and C (P < 0.0002, P < 0.0001 and P < 0.003, respectively, for group A vs group B; and P < 0.0005, P < 0.0002 and P < 0.03, respectively, for group A vs group C). The MDA level of group B was significantly higher than that in group C (P < 0.0002). SOD, GSH-Px and CAT levels of group B were significantly lower than in group C (P < 0.0002, P < 0.0002 and P < 0.003, respectively). According to these results, we suggest that catechin protects liver parenchyma against the toxic effect of halothane and its metabolites, and that, compared to invasive histo-chemical analysis, hepatobiliary scintigraphy is a useful and alternative noninvasive method for detecting the protective effect of catechin on liver parenchyma after halothane anaesthesia. ((C) 2002 Lippincott Williams & Wilkins).Öğe I-123 MIBG scintigraphy in the detection of amiodarone induced pulmonary toxicity(Springer-Verlag, 2001) Altun, GD; Altun, A; Salihoglu, YS; Sankaya, A; Özbay, G; Berkarda, S[Abstract Not Available]Öğe The role of hepatobiliary scintigraphy in the evaluation of the protective effects of dimethylsulphoxide in ischaemic/reperfusion injury of liver(Lippincott Williams & Wilkins, 2000) Yüksel, M; Hatipoglu, A; Temiz, E; Salihoglu, YS; Hüseyinova, G; Berkarda, SLiver ischaemia may lead to parenchymal damage depending on the duration of the ischaemia. Dimethylsulphoxide (DMSO), a well-known radical oxygen scavenger, is a protective agent against ischaemia/reperfusion injury. In this study we aimed to investigate the role of hepatobiliary scintigraphy (HBSc) in detecting the protective effect of DMSO. Eighteen rabbits, in three groups of six, were injected with 37 MBq technetium-99m-mebrofenin via the ear veins. Dynamic scintigrams were taken for 60 min (1 frame/min). In group A, HBSc was performed without any surgery. In groups B and C the Pringle manoeuvre (PM) was applied for 30 min, and tissue specimens for electron microscopy were taken from the liver parenchyma 5 min after the end of the PM. In addition, in group C 1 g/kg DMSO was injected into each rabbit 5 min before application of the PM. HBSc was then performed in groups 5 and C. From the dynamic images time-activity curves (TACs) were obtained for each group, and the time of peak uptake (TPU) and time for half of the activity to clear from the liver (T 1/2) were calculated. The TPU and T 1/2 of group B were significantly longer than those of groups A and C (P <0.0005 and P < 0.005 for TPU, and P<0.0005 and P<0.02 for T 1/2 respectively). The TPU and T 1/2 of group C were significantly longer than those of group A (P <0.005 and P<0.02, respectively). While the electron microscopic images in group C showed reversible changes, those in group B showed both irreversible and reversible changes. The electron microscopic findings of groups B and C confirmed the scintigraphic findings. In conclusion, HBSc might be used as a practical quantitative method for detecting the protective effects of DMSO. However, its clinical value should be evaluated by further studies with human subjects. ((C) 2000 Lippincott Williams & Wilkins).Öğe Use of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: a comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy(Japanese Society Nuclear Medicine, 2005) Durmus-Altun, G; Altun, A; Aktas, RG; Salihoglu, YS; Yigitbasi, NOThe purpose of the study was; (i) to deter-mine whether I-123-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with Tc-99m-DTPA radioacrosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent I-123-MIBG and Tc-99m-DTPA radioaerosol scintigraphy at the end of the treatment period. I-123-MIBG static thorax images were obtained during 10 minutes at 15 minutes and 3-hours after 'intravenous injection of the radiopharmaccutical. Lung to heart ratios (LHR) and lung to mediastinum ratios (LMR), and retention index (LRI) of I-123-MIBG were determined. Two days after I-123-MIBG scintigraphy, 99mTc-DTPA radioaerosol scintigraphy was performed, and clearance from the lungs was measured for 10 min (1 min/frame) following termination of inhalation. I-123-MIBG lung retention index (LRI) was significantly higher in the AIPT group than the control (61 +/- 4.6 vs. 40 +/- 4.5, p = 0.01). Early LHR and LMR were significantly lower in the AIPT group than in the control group (p = 0.04, p = 0.01, respectively), whereas those of late LHR and LMR were not significantly different. T-1/(2) values of DTPA clearance were significantly increased in AIPT group according to the control group (55 +/- 7.2 vs. 86.6 +/- 18.5,p = 0.02). I-123-MIBG scintigraphy is a valuable tool for detecting AIPT in a rabbit model. Additionally, Tc-99m-DTPA radioaerosol scintigraphy is an excellent comprehensive investigational tool for detecting AIPT with the added advantage of lower cost.Öğe Value of technetium-99m diethyltriamine pentaaceticacid radioaerosol inhalation lung scintigraphy for the stage of amiodarone-induced pulmonary toxicity(Elsevier Ireland Ltd, 2004) Durmus-Altun, G; Altun, A; Salihoglu, YS; Altaner, S; Berkada, S; Ozbay, GBackground: Amiodarone is a potent antiarrhythmic agent that is limited in clinical use by its adverse effects, including potentially life threatening amiodarone-induced pulmonary toxicity (AIPT). The alteration of technetium-99m diethyltriaminepentaaceticacid (Tc-99m DTPA) radioaerosol lung clearance in AIPT was experimentally investigated. Methods: Eighteen white New Zealand rabbits (initial weight 4.1 +/- 0.2 kg) were divided into two groups. AIPT group (n = 13) was administered amiodarone (20 mg/kg BW) ip as a 5% aqueous solution for 6 week. The controls (n = 5) were administered the same amount of 0.9% saline ip. Four rabbits of AIPT group died due to AIPT. The reminders of AIPT group (n = 9) and controls underwent Tc-99rn DTPA radioaerosol lung scintigraphy at the end of the treatment period. AIPT group was divided into two subgroups according to histopathologic evaluation. AIPT-I had interstitial pneumonitis (n = 4) and AIPT-II had interstitial pneumonitis with fibrosis (n=5). Results: The mean T-1/2 values of in control, AIPT-I, and AIPT-II groups were found 54 +/- 4.4, 39.2 +/- 11.7 and 114.6 +/- 16.7 min, respectively. The mean T-1/2 values of Tc-99m DTPA significantly differ than other groups (chi(2) = 11.78, P=0.02). The significantly increased T-1/2 values was noted in AIPT-II group when compared with control (P=0.001). In contrast, AIPT-I group has significantly lower T-1/2 values than control group (P=0.03). Conclusion: We suggested that Tc-99m DTPA radioaerosol inhalation lung scintigraphy provides an accurate evaluation about stage of lung toxicity and therefore may be a useful tool for the monitoring of AIPT. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
