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Öğe Analgesic effect of metformin on hyperalgesia induced by REM sleep deprivation(Wiley, 2023) Gurel, Elif Ezgi; Ozturk, Gulnur; Ozturk, Levent; Tosunoglu, Esra Akbas; Gul, Tugba Kizil; Arslan, Enver[Abstract Not Available]Öğe Blood pressure, autonomic stress, and inflammatory markers during sleep deprivation and recovery in healthy men(Turkish Soc Cardiology, 2021) Bozer, Ozge; Kaya, Oktay; Ozturk, Gulnur; Bulut, Erdogan; Zorkun, Cafer; Ozturk, LeventObjective: Recent community-based studies have identified sleep deprivation (SD) as an important modifiable risk factor for hypertension However, the underlying mechanisms linking SD to hypertension remain elusive. Thus, this study investigates blood pressure (BP) responses to cardiac autonomic stress tests in the presence of SD. Furthermore, we analyzed vascular inflammatory biomarkers as a possible underlying factor linking SD to increased BP. Methods: Ten healthy male volunteers (age, 21.6 +/- 1.2 years) underwent repeated autonomic stress tests for three consecutive days (baseline, SD, and recovery). The autonomic stress tests included the Valsalva maneuver, mental arithmetic, isometric handgrip, and cold pressor tests. Each day, resting BPs were measured, venous blood samples were collected for intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E-selectin measurements, and stress tests were performed between 0900 and 1100. Ambulatory BP was recorded during the entire SD period (24 h). Results: One-night SD abolished BP reactivity to the Valsalva maneuver, isometric hand grip, and cold pressor tests, which returned after recovery sleep. Ambulatory BP monitoring showed that the mean systolic and diastolic BPs were 121.1 +/- 8.5 mm Hg and 72.8 +/- 6.3 mm Hg, respectively, between 0700 and 2300 and 120.3 +/- 9.6 mm Hg and 74.1 +/- 6.1 mm Hg, respectively, between 2300 and 0700 during the SD day (p>0.05 for both). Vascular inflammatory markers seemed unrelated to BP changes. Conclusion: Acute SD altered BP responses to cardiac autonomic stress tests in healthy men without affecting resting BP levels. SD led to a non-dipping pattern in BP oscillation. Collectively, these findings highlight the importance of sleep in regulating BP.Öğe Circadian Rhythms and Organ Physiology: From Center Clock to Peripheral Clocks(Wiley, 2019) Ozturk, Gulnur[Abstract Not Available]Öğe Diagnostic Value of Gait Analysis in Patients with Lumbar Disc Herniation(Wiley, 2019) Delen, Emre; Ozturk, Gulnur; Karahan, Menekse; Ulucam, Enis; Ozturk, Levent[Abstract Not Available]Öğe The Effect of Ginkgo Biloba on Hyperalgesia Induced by REM Sleep Deprivation(Wiley, 2023) Gurel, Elif Ezgi; Ozturk, Levent; Ozturk, Gulnur; Deger, Ecem Busra; Tosunoglu, Esra Akbas[Abstract Not Available]Öğe The Effect of Metformin on Hyperalgesia Induced by REM Sleep Deprivation(Wiley, 2022) Gurel, Elif Ezgi; Ozturk, Gulnur; Gunduz, Samime Sarli; Tosunoglu, Esra Akbas; Ozturk, Levent[Abstract Not Available]Öğe The Effect of Music on Subjective Time Perception(Wiley, 2019) Gul, Tugba Kizil; Ozturk, Gulnur; Kaya, Oktay; Sen, Burcu; Memi, Gulsun; Ozturk, Levent[Abstract Not Available]Öğe The effect of one-night sleep deprivation on cognitive functions in healthy young adults(Brazilian Assoc Sleep, 2021) Pekcetin, Serkan; Ozturk, Gulnur; Cetin, Buse; Ozturk, LeventIntroduction: The effects of acute sleep deprivation on cognitive function have not been clearly elucidated. The purpose of this study was to evaluate changes in cognitive function in healthy adults after one night of sleep deprivation. Material and Methods: Twenty-one healthy young adults (aged 18-30 years) underwent assessment of cognitive functions before and after one night of total sleep deprivation and an age- and gender-matched control group was assessed before and after a normal night sleep. Cognitive functions were assessed using the Montreal cognitive assessment (MOCA) and trail making test (TMT) parts A and B. Results: General linear model repeated measures demonstrated an insignificant effect for time x group (sleep deprivation) interaction for MOCA, TMT Part A, and TMT Part B scores after one-night sleep deprivation (p>.05 for all). Conclusion: A single night of sleep deprivation, which can be inevitable in modern society, had no significant effect on cognitive performance in healthy adults.Öğe The effect of progressive muscle relaxation exercises on compassion satisfaction, burnout, and compassion fatigue of nurse managers(Wiley, 2021) Semerci, Remziye; Ozturk, Gulnur; Akgun Kostak, Melahat; Elmas, Saadet; Ihsan Danaci, Ali; Musbeg, SadberPurpose To investigate the effect of progressive muscle relaxation exercises on compassion satisfaction, burnout, and compassion fatigue of nurse managers. Design and Methods A pretest, posttest, one-group quasi-experimental study was carried out with 30 nurse managers and they were received Jacobson: Progressive Muscle Relaxation Exercises in a group once in a week for 8 weeks. Findings After the second month, the mean compassion fatigue (p < 0.01) and the mean burnout scores (p = 0.01) were decreased. Practice Implications It is recommended to expand progressive muscle relaxation exercises and to conduct studies in different groups to increase the professional quality of life.Öğe The Effect of Resveratrol on Hyperalgesia Induced by REM Sleep Deprivation(Wiley, 2023) Gurel, Elif Ezgi; Ozturk, Levent; Ozturk, Gulnur; Gunduz, Samime Sarli; Deger, Ecem Busra[Abstract Not Available]Öğe Effects of Sleep Deprivation on Proprioception in Healthy Young Adults(Wiley, 2018) Cetin, Buse; Ozturk, Gulnur; Ulucam, Enis; Yilmaz, Ali; Ozturk, Levent[Abstract Not Available]Öğe Evaluation of Olivocochlear Efferent Supression and Auditory Frequency Perception in Musicians(Wiley-Blackwell, 2015) Bulut, Erdogan; Ozturk, Gulnur; Tas, Memduha; Turkmen, Mehmet Turgay; Gulmez, Dilek; Ozturk, Levent[Abstract Not Available]Öğe Flurbiprofen in rapid eye movement sleep deprivation induced hyperalgesia(Pergamon-Elsevier Science Ltd, 2014) Gurel, Elif Ezgi; Ural, Keremcan; Ozturk, Gulnur; Ozturk, LeventBackground: Rapid eye movement (REM) sleep deprivation induces hyperalgesia in healthy rats. Here, we evaluated the effects of flurbiprofen, an anti-inflammatory and neuroprotective agent, on the increased thermal responses observed in REM sleep deprived rats. Methods: Forty female rats were divided into four groups following 96-hour REM sleep deprivation: intraperitoneal injections of placebo, and flurbiprofen 5 mg/kg, 15 mg/kg and 40 mg/kg were made in CONT (n = 10), FBP5, FBP15 and FBP40 groups respectively. Pain threshold measurements were performed three times at baseline (0.hour), at the end of REM sleep deprivation (96.hour) and at 1 h after injections (97.hour) by hot plate and tail-flick tests. Results: REM sleep deprivation induced a significant decrease in pain thresholds of all rats (hotplate: 0.hour vs 96.hour, 9.75 +/- 2.85 vs 5.10 +/- 2.02, p < 0.001; tail flick: 0.hour vs 96.hour, 11.92 +/- 4.62 vs 7.92 +/- 5.15, p < 0.001). Flurbiprofen in 15 mg/kg and 40 mg/kg doses significantly improved pain tolerance measured by tail flick test (tail flick in FBP15 and FBP40 groups: 96.hour vs 97.hour, 7.01 +/- 4.97 vs 8.34 +/- 3.61 and 5.06 +/- 1.57 vs 7.04 +/- 2.49, p < 0.05 for both). Conclusion: 96 h of REM sleep deprivation resulted in reduced pain thresholds in both hot plate and tail flick tests. Flurbiprofen was used for the first time in a rat model of REM sleep deprivation, and it provided antinociceptive effects in 15 mg/kg and 40 mg/kg doses. Flurbiprofen may have the potential for treatment of painful syndromes accompanying insomnia or sleep loss. (C) 2014 Elsevier Inc. All rights reserved.Öğe Individuals with a COVID-19 history exhibit asymmetric gait patterns despite full recovery(Elsevier Sci Ltd, 2022) Keklicek, Hilal; Selcuk, Halit; Kurt, Ilke; Ulukaya, Sezer; Ozturk, GulnurCOVID-19 is a multisystem infectious disease affecting the body systems. Its neurologic complications include -but are not limited to headache, loss of smell, encephalitis, and cerebrovascular accidents. Even though gait analysis is an objective measure of the neuro-motor system and may provide significant information about the pathophysiology of specific diseases, no studies have investigated the gait characteristics in adults after full recovery from COVID-19. This was a cross-sectional, controlled study that included 12 individuals (mean age, 23.0 +/- 4.1 years) with mild-to-moderate COVID-19 history (COVD) and 20 sedentary controls (CONT; mean age, 24.0 +/- 3.6 years). Gait was evaluated using inertial sensors on a motorized treadmill. Spatial-temporal gait parameters and gait symmetry were calculated by using at least 512 consecutive steps for each participant. The effect-size analyses were utilized to interpret the impact of the results. Spatial-temporal gait characteristics were comparable between the two groups. The COVD group showed more asymmetrical gait patterns than the CONT group in the double support duration symmetry (p = 0.042), single support duration symmetry (p = 0.006), loading response duration symmetry (p = 0.042), and pre-swing duration symmetry (p = 0.018). The effect size analyses of the differences showed large effects (d = 0.68-0.831). Individuals with a history of mild-to-moderate COVID-19 showed more asymmetrical gait patterns than individuals without a disease history. Regardless of its severity, the multifaceted long-term effects of COVID-19 need to be examined and the scope of clinical follow-up should be detailed.Öğe Optimum test conditions for cold water face immersion test(Wiley, 2023) Arslan, Enver; Oner, Ozan; Comart, Ali; Ozturk, Gulnur[Abstract Not Available]Öğe Regular Aerobic Training Combined with Range of Motion Exercises in Juvenile Idiopathic Arthritis(Hindawi Ltd, 2014) Apti, Mine Dogru; Kasapcopur, Ozgur; Mengi, Murat; Ozturk, Gulnur; Metin, GokhanObjective. To assess the effects of regular aerobic training combined with range of motion (ROM) exercises on aerobic capacity, quality of life, and function in children with juvenile idiopathic arthritis (JIA). Methods. Thirty patients with JIA and 20 healthy age- matched controls (mean age +/- SD, 11.3 +/- 2.4 versus 11.0 +/- 2.3, resp.;.. > 0.05) were included. All patients performed aerobic walking (4 days a week for 8 weeks) and active and passive ROMexercises of involved joints. All patients completed the childhood health assessment questionnaire (CHAQ) and the child health questionnaire. ROM measurements of joints were performed by using universal goniometer. Aerobic capacity was determined by measuring peak oxygen uptake (VO2peak) during an incremental treadmill test. Results. Peak oxygen uptake and exercise duration were significantly lower in JIA group than in controls (32.5 +/- 6.6 versus 35.9 +/- 5.8 and 13.9 +/- 1.9 versus 15.0 +/- 2.0, resp.; < 0.05 for both). Eight- week combined exercise program significantly improved exercise parameters of JIA patients (baseline versus postexercise VO2peak and exercise duration, 32.5 +/- 6.6 to 35.3 +/- 7.9 and 13.9 +/- 1.9 to 16.3 +/- 2.2, resp.;.. < 0.001 for both). Exercise intervention significantly improved CHAQ scores in JIA patients (0.77 +/- 0.61 to 0.20 +/- 0.28, P < 0.001). Conclusion. We suggest that regular aerobic exercise combined with ROM exercises may be an important part of treatment in patients with JIA.Öğe The Role of Cannabinoid Receptors on Pain Behavior-induced by REM Sleep Deprivation(Wiley-Blackwell, 2016) Yilmaz, Makbule Elif; Kaya, Oktay; Gunduz, Ozgur; Ozturk, Gulnur; Ozturk, Levent[Abstract Not Available]Öğe Stress-Induced Heart Rate Variability Under The Conditions of Acute Sleep Deprivation: Effects of Caffeine or Nap(Wiley, 2023) Kurtaran, Nurcan Erdogan; Ozturk, Gulnur; Gunduz, Samime Sarli; Gurel, Elif Ezgi; Erge, Ummuhan; Ozturk, Levent[Abstract Not Available]Öğe Systemic Irisin Levels in Healthy Young Adult Subjects(Wiley-Blackwell, 2015) Avci, Bengu; Kaya, Oktay; Gunduz, Ozgur; Ozturk, Gulnur; Nakus, Engin; Ozturk, Levent[Abstract Not Available]Öğe Verdi A (432 Hz) versus Standard A (440 Hz) in Music-related Electrical Activity of Brain: An EEG Analysis of Sultaniyegah Agir Semai Composed by Hammamizade Ismail Dede Efendi(Wiley-Blackwell, 2016) Ozturk, Gulnur; Bulut, Erdogan; Umut, Ilhan; Ozturk, Levent[Abstract Not Available]
