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    BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES
    (Trakya Univ Balkan Yerlesesi Enstituler Binasi, 2022) Eruygur, Nuraniye; Ozpinar, Necati; Ozpinar, Hulya; Atas, Mehmet; Tekin, Mehmet; Cevik, Ozge
    This study was performed in order to evaluate in vitro antioxidant, anti-Trichomonas vaginalis, antimicrobial and cytotoxic activities of methanol extracts of aerial parts of Hypericum perforatum L., H. thymbrifolium Boiss. & Noe and H. thymopsis Boiss. The antioxidant activity of methanol extracts was tested with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging and iron chelating assays. The total phenol and flavonoid contents were also determined spectrophotometrically. Cytotoxicity and apoptosis were evaluated on MCF-7 breast cancer and PC3 prostate cancer cell line. Antimicrobial activities were evaluated by the microdilution method on the bacterial strains Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853) Escherichia coli (ATCC 25922) and the fungal strain Candida albicans (ATCC 10231). All extracts demonstrated cytotoxic activity on PC3 prostat cancer cell line with a concentration dependent manner, while H. thymopsis extract was the most active against cancer cell growth. The obtained results of the present study revealed that the methanol extract of H. perforatum, H. thymbrifolium and H. thymopsis have significant antioxidant and cytotoxic activities. The results provided the basic research data for further phytochemical and biological activity guided investigations on these species for identication and isolation of potential drug active compounds.
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    IN-VITRO ANTIOXIDANT, A-GLUCOSIDASE AND A-AMYLASE INHIBITORY ACTIVITIES OF CRUDE ETHANOL EXTRACT AND FRACTIONS OF ENDEMIC HYACINTHELLA ACUTILOBA K.PERSS. & WENDELBO BULBUS
    (Parlar Scientific Publications (P S P), 2019) Eruygur, Nuraniye; Dural, Emrah; Tekin, Mehmet; Ozpinar, Hulya
    In the present study, the antioxidant potential as well as the alpha-amylase and alpha-glucosidase inhibitory activity of different extracts of Hyacinthella acutiloba bulbus were investigated using an in vitro model. Antioxidant activity was assayed by the DPPH radical scavenging activity, total phenol content (TPC) and total flavonoid content (TFC), reducing power assay, ferric thiocyanate (FTC) and thiobarbituric acid method (TBA). Among the extracts, n-hexane and chloroform extract of H. acutiloba displayed more activity than other extracts against a amylase and alpha-glucosidase.