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Öğe The effects of melatonin on postoperative intraabdominal adhesion formation(Yonsei Univ College Medicine, 2007) Hatipoglu, Ahmet; Turkyilmaz, Zeliha; Mert, SelvaPurpose: Postoperative intraabdominal adhesion formation is a major clinical problem. No previous study was found, reporting the relationship between adhesion formation and melatonin administration, but melatonin, a strong antioxidant, is recognized to have certain effects on the progression of adhesion formation mechanism. It was therefore decided to investigate the effects of melatonin on postoperative adhesion formation. Materials and Methods: A total number of 24 Spraque-Dawley rats were utilized. Three groups, described as: Group A, sham laparatomy (n = 8), Group B, rats that underwent only ischemia-reperfusion (n = 8) and Group C, rats that underwent ischemia-reperfusion and were given 10 mg/kg melatonin solution i.v. (n = 8). For Groups B and C, the ileocolic vessels were clamped. Blood glutathione peroxidase levels of all study groups were assessed, then microscopic and macroscopic adhesion scores were evaluated. Results: Glutathione peroxidase levels of the melatonin-treated group were significantly higher and fibroblast proliferation and macroscopic adhesion scores were significantly lower, than in the melatonin-free group. Conclusion: The results of this study supported the hypothesis, that melatonin administration may prevent intraabdominal adhesions resulting from surgery.Öğe Evaluation of pulmonary alveolo-capillary permeability in Type 2 diabetes mellitus using technetium 99mTc-DTPA aerosol scintigraphy and carbon monoxide diffusion capacity(Elsevier Science Inc, 2006) Ozsahin, Kemal; Tugrul, Armagan; Mert, Selva; Yuksel, Mahmut; Tugrul, GozdeThe thickening of alveolar basement membrane is found in autopsies, along with microvascular pathologies, in Type I and 2 diabetes mellitus (DM). To detect the function and permeability of alveolar basement membrane, carbon monoxide diffusion capacity (DLCO) and technetium 99m-diethyltriaminepentaaceticacid (Tc-99m-DTPA) aerosol scintigraphy methods can be used. The aim of this study was to determine alveolar basement membrane damage using these two methods. Nineteen women and 6 men, nonsmoking, Type 2 DM cases, without any lung and/or heart disease and who had neither anemia nor obesity, made up the patient group. They were compared with six female and nine male healthy cases who had the same characteristics with the diabetes cases. All of the cases DLCO were measured by single-breath method and 99mTc-DTPA aerosol scintigraphy was performed. DLCO showed no difference between the two groups. Aerosol scintigraphy was significantly decreased in the diabetic group (P=.01). In cases with > 5 years of diabetic duration (P <.01), in cases with glycolized hemoglobin (HbA(1c)) <= 8% (P <.05) and > 8% (P <.05), and in microangiopathic cases (P <.01), alveolo-capillary permeability was significantly decreased than in the control group. Among the same groups, no significant difference could be detected for DLCO. The permeability of alveolar basement membrane can reduce in respect to diabetes duration and poor metabolic control. According to our investigation, Tc-99m-DTPA aerosol scintigraphy method is more sensitive than DLCO method for determining these pathologies. (c) 2006 Elsevier Inc. All rights reserved.Öğe İnsanda serum melatonin, T3, T4 düzeyleri ve eksojen melatoninin serum T3 ve T4 düzeylerine etkileri(Trakya Üniversitesi, 2001) Mert, Selva; Yaprak, Mevlüt7. ÖZET Pineal bez ve tiroid bezinin birbirlerinin fonksiyonlarım etkiledikleri konusunda yapılmış insan ve hayvan çalışmaları mevcuttur. Ancak klinik araştırmaların sayısı daha azdır. Genel kam melatoninin tiroid fonksiyonlarını inhibe ettiği yönündedir. Bu çalışma iki aşamada gerçekleştirilmiştir. İlk aşamada hipertiroidililerde (n=10), hipotiroidililerde (n=10) ve kontrol grubunda (n=10) serum MLT, T3, T4 ve TSH düzeyleri çalışılmıştır. İkinci aşamada ise sağlıklı genç erişkinlere sabah ve akşam oral yolla verilen 1,5 mg eksojen melatoninin serum T3, T4, TSH ve MLT düzeylerine etkileri araştırılmıştır. İkinci aşamada 40 sağlıklı denek her biri 5 kadın ve 5 erkekten oluşan 4 gruba ayrılmıştır. Grupların ikisi ile sabah, ikisi ile akşam üzeri çalışılmıştır. Sabah ve akşam gruplarından biri deney, biri kontrol grubuydu. Deney gruplarına melatonin kontrol gruplarına plasebo verildi. Melatonin ve plasebo verilmesinden hemen önce ve 1 saat sonra alman kan örneklerinde T3, T4, TSH ve MLT çalışılmıştır. Tüm kan örneklerinden elde edilen serumlarda hormon düzeyleri RIA yöntemiyle ölçülmüştür. Hipotiroidi hastalarında melatonin düzeyleri kontrollere oranla yüksek bulunmuştur. Deneklere saat 18:00'de verilen eksojen melatoninin T4 ve TSH düzeylerini düşürdüğü gözlenmiştir. Bu çalışmanın sonuçlan melatoninin tiroid fonksiyonlarını inhibe edici etkisinin olduğu görüşünü desteklemektedir. Anahtar Kelimeler: melatonin, tiroid, pineal, TSH 43Öğe Melatonin administration acutely decreases the diffusing capacity of carbon monoxide in human lungs(Karger, 2006) Vardar, Selma Arzu; Altun, Guelay Durmus; Guenerbueyuek, Caner; Hatipoglu, Osman Nuri; Mert, Selva; Kaymak, KadirBackground: Most physiological measurements of the pulmonary diffusing capacity use carbon monoxide (CO) as a tracer gas. Similar to CO, melatonin binds the hemoglobin in the blood. Objective: The present study was designed to assess the effect of exogenous melatonin administration on pulmonary functions including diffusing capacity for carbon monoxide (DLCO) in healthy subjects. Methods: The study was performed in a randomized, double-blind, placebo-controlled manner. DLCO was measured in 22 healthy male volunteers ( age 18 - 25 years) who were randomized to melatonin (n = 11) and placebo administration ( n = 11). At baseline, DLCO, alveolar volume (V-A) and other spirometric parameters such as forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and maximal voluntary ventilation (MVV) were measured. DLCO was then corrected for the hemoglobin concentration. Measurements were repeated in a double-blind fashion 60 min after the administration of melatonin ( 1 mg) or placebo. Results: DLCO was significantly decreased (39.31 +/- 4.75 vs. 34.82 +/- 6.18 ml/min/mm Hg) 60 min after the melatonin administration ( p = 0.01), while FEV1, FVC, FEV1/FVC, PEF and MVV values did not demonstrate significant differences. Placebo administration did not result in significant alteration in any of these parameters. Conclusions: In healthy subjects, oral administration of melatonin acutely influences the DLCO without affecting other pulmonary function test results. We conclude that melatonin may have a reducing effect on the DLCO in the lungs. Copyright (C) 2006 S. Karger AG, Basel.
