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    Oxidative stress in the blood of patients with active localized vitiligo
    (Dermatovenerological Soc Slovenia, 2008) Arican, O.; Kurutas, E. B.
    Objectives: Vitiligo is an acquired skin disease characterized by white areas on the skin. The pathogenesis of the disease is still unclear. Some findings show that oxidative stress could be an important phenomenon in the pathophysiology of vitiligo. Methods: We evaluated 16 consecutive localized vitiligo patients and 16 healthy controls of a similar age and sex distribution. We measured their indicators of oxidative stress such as catalase (CAT), superoxide dismutase (SOD), glucose 6-phosphate dehydrogenase (G6PD) in erythrocytes, and plasma malondialdehyde (MDA) by spectrophotometry. Results: SOD activities and MDA levels of patients were significantly higher than controls (p < 0.001). CAT and G6PD activities of patients were significantly lower than controls (p < 0.05 and p < 0.001, respectively). Conclusion: Our results confirmed that oxidative stress may play an important role in the pathogenesis of vitiligo. Melanocyte damage in vitiligo might be linked to generalized oxidative stress. This study is the first report on some antioxidant parameters of localized-type vitiligo patients.
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    Status of oxidative stress on lesional skin surface of plantar warts
    (Wiley, 2013) Arican, O.; Ozturk, P.; Kurutas, E. B.; Unsal, V.
    Background Warts are abnormal skin growths caused by human papilloma virus (HPV) infections within the skin of the patients. Sometimes the disease is difficult to treatment, and also, the relationship between HPV and some forms of skin cancers is important. The cutaneous oxidative stress status of warts is absent in the literature. Objectives To evaluate the role of oxidative stress in affected skin areas in a group of patients with plantar warts. Methods Thirty-six consecutive patients with a diagnosis of plantar warts were enrolled. The samples were obtained by scraping the skin surface. Superoxide dismutase (SOD) and catalase (CAT) activities and malondialdehyde (MDA) levels were measured spectrophotometrically at samples. Results The SOD activity was significantly lower, and the MDA level was significantly higher on the lesional area than on the non-lesional area (P<0.001 for each), and there was no significant difference in the CAT activity between both areas (P=0.11). Conclusion Cutaneous oxidative stress in patients with plantar warts may play a role in pathogenesis of the disease. The addition of topical drugs with antioxidative effects may be valuable in the treatment of warts.