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Öğe Assessment of quality of life in patients with laryngeal cancer after surgical treatment(2004) Taş A.; Yagiz R.; Karasalihoglu A.R.; Koten M.; Adali M.K.; Uzun C.OBJECTIVES: To evaluate quality of life of patients undergoing surgical treatment for larynx cancer and to compare quality of life between patients with total laryngectomy and partial laryngectomy. PATIENTS AND METHODS: Thirty-two questions were asked to patients who underwent total laryngectomy (22 subjects) or partial laryngectomy (24 subjects). These questions were based on the European Organization for Research on Treatment of Cancer questionnaires Quality of Life--C30 (EORTC-QoL-C30) and adapted to our nation. Patients with total laryngectomy and partial laryngectomy were compared according to the answers. RESULTS: We found significant statistical differences between total and partial laryngectomy patients in 12 questions. When functional disorders were evaluated, the most significant was one associated with communication. However, pain, smell disorders and increased secretion were associated with morbidity that resulted from the type of surgery. It was observed that patients with total laryngectomy were particularly affected psychologically and economically. CONCLUSION: Patients subjected to total laryngectomy experience serious physical and psycho-social disadvantages that arise from the treatment. In order to establish these negative effects and to minimize them, tools of assessment of quality of life should be developed. This assessment should be appropriate for our nation, providing information and psychological support for individuals and their families.Öğe Bilateral choanal atresia in premature monozygotic twins(2005) Vatansever Ü.; Duran R.; Acunaş B.; Koten M.; Adali M.K.Bilateral congenital choanal atresia is a relatively rare anomaly of the upper airway, which may cause life-threatening respiratory emergency and require rapid diagnosis and treatment. This condition usually occurs sporadically, but has also been rarely described in siblings. We present monozygotic premature twin infants with identical findings of bilateral choanal atresia and no other associated anomalies. To our knowledge, this is the first report of such an occurrence. © 2005 Nature Publishing Group All rights reserved.Öğe A case of epithelial-myoepithelial carcinoma of the parotid gland.(2003) Taş A.; Yagiz R.; Altaner S.; Koten M.; Karasalihoglu A.R.Epithelial-myoepithelial carcinomas comprise approximately 1% of all salivary gland neoplasms. Most tumors arise in the major salivary glands, especially in the parotid gland. We present a case of epithelial-myoepithelial carcinoma of the parotid gland in a 65-year-old male patient. Magnetic resonance imaging showed an irregular and heterogeneous mass in the left parotid gland. Superficial parotidectomy was performed. There was no evidence of recurrence during a 21-month follow-up.Öğe [Effect of the levels of vascular endothelial growth factor-A and C on the prognosis of patients with laryngeal carcinoma].(2011) Düzen B.; Taş A.; Demir M.; Usta U.; Ya?iz R.; Koten M.; Karasaliho?lu A.In this study, we determined the prognostic importance of vascular endothelial growth factor (VEGF)-A and C values and their relationship with tumor stages and neck lymp node involvement and also, the relationship between microvessel density and tumor stage in the pathologic specimens. Thirty-three male patients (mean age 57.8±7.2 years; range 49 to 69 years) who underwent surgical treatment for laryngeal squamous cell carcinoma and a control group of 13 healthy male subjects (mean age 54.2±6.1 years; range 41 to 62 years) were included in the study. Patients were divided into two groups: the early-stage group consisting of patients with T1 and T2 stage tumors and the advanced stage group including patients with T3 and T4 stage tumors. Patients are evaluated in terms of plasma VEGF-A and C levels before and six months after the surgery. In the pathologic specimens, CD 31 was used for immunohistochemical staining. For each patient the number of microvessels per millimeter square (microvessel density) was determined. The preoperative plasma VEBF-A levels of the patients with early-stage tumors were significantly lower compared to those of the control group, while there was no significant difference between the preoperative levels of the patients with advanced stage tumors and the levels of the control group. There was no significant difference between the preoperative and postoperative 6th month VEGF-A levels of the patients both in the early-stage and the advanced stage groups. The preoperative plasma VEGF-C values of the patients with lymph node involvement were significantly lower than those of the patients with early-stage tumors. There was no significant difference between the VEGF-C levels in pre- and postoperatively at six months after the operation of patients with lymph node involvement. There was no significant difference between the preoperative VEGF-C levels of the patients with lymph node involvement and those without lymph node involvement. No significant difference was found in microvessel density between the cases with early and advanced stage tumors. It was seen that the plasma VEGF-A value did not increase in patients with laryngeal cancer and rather it is low in patients with early-stage disease. No relationship was found between the plasma VEGF-C values and cervical lymph node involvement.Öğe Effects of antibiotic solutions (ciprofloxacin and trimethoprim + sulphamethoxazole) on rabbit tympanic membrane(1995) Karasolihoglu A.; Adali M.K.; Koten M.; Seker V.; Kutlu K.This study was designed to assess morphological changes in the rabbit tympanic membrane after ciprofloxacin and trimethoprim + sulphamethoxazole had been instilled as a single dose into the middle ear cavities of 24 rabbits. At different times the rabbits were decapitated and the lesions which occured on the tympanic membrane were studied histopathologically. Our results indicate that in the ciprofloxacin group reactive inflammatory changes are reversible as in the trimethoprim + sulphamethoxazole group.Öğe McCune-Albright syndrome with fibrous dysplasia of the paranasal sinuses(1999) Uzun C.; Adali M.K.; Koten M.; Karasalihoglu A.R.We report a 19-year old female patient with the McCune-Albright syndrome, which is a rare disease consisting of polyostotic fibrous dysplasia (FD) of bone associated with brown pigmented areas of the skin and several endocrine dysfunctions. The patient had FD involving the paranasal sinuses, the middle turbinate and the skull. The endocrine dysfunction of the patient concerns both growth hormone and prolactin hypersecretion. Because the patient had no major symptoms, neither surgical nor medical treatment was applied. Five-year follow-up revealed no complication and enlargement of the lesion.Öğe The predictive value of assessing mastoid pneumatization in pre-dive examinations(2005) Uzun C.; Taş A.; Ya?iz R.; Adali M.K.; Koten M.; San H.; Karasaliho?lu A.R.OBJECTIVES: We investigated the value of assessing the degree of mastoid pneumatization in predicting middle ear barotrauma -the most common problem in sport SCUBA divers- in comparison with that of the conventional pre-dive examination method, the Valsalva maneuver. MATERIALS AND METHODS: Thirty-four volunteer sport SCUBA divers having normal pre-dive examination findings were included. The Valsalva test was performed in all the divers. Mastoid pneumatization for each ear was calculated on a Schuller's view radiography. Pneumatization of = or <30 cm2 was accepted as poor (prone to barotrauma) and >30 cm2 was accepted as good (not prone to barotrauma). During the observation period, the divers were monitored with regard to barotrauma symptoms and signs. RESULTS: The degree of mastoid pneumatization was = or <30 cm2 in 26 ears (38%) of 16 divers (47%). The Valsalva test was negative in eight ears (12%) of six divers (18%). During a total of 1001 dives, symptomatic middle ear barotrauma occurred in 28 dives (2.8%), i.e. in 21 ears (31%) of 16 divers (47%). Of these, the degree of mastoid pneumatization predicted barotrauma in 11 (69%) divers, whereas the Valsalva test was negative in only three (19%) (p<0.05), with sensitivity, specificity, positive and negative predictive values, and efficiency being 69% and 19%, 72% and 83%, 69% and 50%, 72% and 54%, and 71% and 53%, respectively. CONCLUSION: The value of assessing mastoid pneumatization in predicting middle ear barotrauma in sport SCUBA divers is higher than that of the Valsalva test.Öğe Quality of Life in Rhinosinusitis(Springer International Publishing, 2019) Güven S.G.; Koten M.; Hao S.-P.Negative effects of chronic rhinosinusitis (CRS) on quality of the lives (QOLs) of the individuals have often been overlooked. Nonetheless, numerous individuals state higher influences of CRS on QOL dimensions such as bodily pain or social functioning in comparison with other diseases like angina pectoris, chronic bronchitis, or pulmonary emphysema. Meanwhile, various QOL instruments consistently are being formed and validated in order to measure the subjective outcome of the CRS patients. Health-related quality of life (HRQoL) is a field of quality-of-life assessment, which depends on the individual’s understanding of his or her health condition. Evaluation of healthcare outcomes is essential for the advancement of innovative healthcare service and enhancement of treatment outcomes. Physicians typically utilize HRQoL to determine the impact of chronic disease and be aware of the way a disease disrupts an individual’s daily life. Assessing HRQoL allows health professionals, enhances patient-physician interaction, and improves clinical outcomes. Nevertheless, because of the numerous instruments in use, variety of items and responses evaluated, and lack of familiar units, physicians usually consider the interpretation of HRQoL research challenging. To date, QOL assessments in CRS patients are limited and usually disease-specific questionnaires including Rhinosinusitis Disability Index, the Chronic Sinusitis Survey Score, and the SinoNasal Outcome Test-16 (SNOT-16) have been utilized. The problem with these disease-specific questionnaires is that they do not provide comparisons between various therapeutical interventions and various patient groups, and this makes the interpretation of the effect size difficult. © Springer Nature Switzerland AG 2020.
