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  • Küçük Resim Yok
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    The effects of melatonin on postoperative intraabdominal adhesion formation
    (Yonsei Univ College Medicine, 2007) Hatipoglu, Ahmet; Turkyilmaz, Zeliha; Mert, Selva
    Purpose: Postoperative intraabdominal adhesion formation is a major clinical problem. No previous study was found, reporting the relationship between adhesion formation and melatonin administration, but melatonin, a strong antioxidant, is recognized to have certain effects on the progression of adhesion formation mechanism. It was therefore decided to investigate the effects of melatonin on postoperative adhesion formation. Materials and Methods: A total number of 24 Spraque-Dawley rats were utilized. Three groups, described as: Group A, sham laparatomy (n = 8), Group B, rats that underwent only ischemia-reperfusion (n = 8) and Group C, rats that underwent ischemia-reperfusion and were given 10 mg/kg melatonin solution i.v. (n = 8). For Groups B and C, the ileocolic vessels were clamped. Blood glutathione peroxidase levels of all study groups were assessed, then microscopic and macroscopic adhesion scores were evaluated. Results: Glutathione peroxidase levels of the melatonin-treated group were significantly higher and fibroblast proliferation and macroscopic adhesion scores were significantly lower, than in the melatonin-free group. Conclusion: The results of this study supported the hypothesis, that melatonin administration may prevent intraabdominal adhesions resulting from surgery.
  • Küçük Resim Yok
    Öğe
    A RARE BREAST TUMOR: SECRETORY BREAST CARCINOMA
    (Aves, 2011) Yagci, Mehmet Ali; Sezer, Atakan; Yeldan, Eyup; Hoscoskun, Zeki; Hatipoglu, Ahmet; Altaner, Semsi; Cicin, Irfan
    Secretory breast carcinoma is a rare type of invasive breast cancer. The tumor was first reported in pediatric patients, but actual incidence among pediatric and adult decades is similar. We present the case of a 50-year-old woman with a secretory breast carcinoma treated by breast conserving surgery and sentinel node dissection followed by chemotherapy and radiotherapy. The patient has meanwhile completed 3 years of follow-up with no evidence of recurrence. Secretory breast carcinoma usually has a low progression rate, and the prognosis is usually favorable. The choice of treatment should be patient based and minimal invasive procedures consist of breast conserving surgeries and sentinel node biopsies should be favoured. Systemic treatment and radiotherapy are points still awaiting for further investigation.