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    DIFFERENTIAL ROLE OF NUCLEUS-ACCUMBENS AND CAUDATE-PUTAMEN IN MEDIATING THE EFFECT OF NOMIFENSINE AND METHAMPHETAMINE ON AMBULATION AND REARING OF RATS IN THE OPEN-FIELD TEST
    (Japanese Pharmacological Soc, 1995) ALKHATIB, IMH; DOKMECI, I; FUJIWARA, M
    The effects of nomifensine (NOM) and methamphetamine (MA) on ambulation and rearing of rats in the open-field test were investigated. NOM and MA were injected i.p. into intact rats and nucleus accumbens (ACC)- and caudate-putamen (CP)-lesioned rats and infused into the ACC and CP. NOM (1-10 mg/kg, i.p.) and MA (1-5 mg/kg, i.p.) produced hyperactivity. However, NOM at 20 mg/kg, i.p. decreased the activity and induced repetitive head bobbing and squatting. Lesions of the ACC and CP increased open-field activity. However, lesion of the CP increased rearing more than lesion of the ACC. The increase in ambulation induced by NOM was inhibited by lesion of the ACC, whereas that induced by MA was inhibited by lesion of the CP. Although NOM (1-10 mu g/2 mu l) and MA (0.5-10 mu g/2 mu l) injections into the ACC and CP induced hyperactivity, the effect of NOM was greater after injection into the ACC, whereas the effect of MA was greater following injection into the CP. These results suggest that the ACC has a greater role in ambulation, while CP has a greater one in rearing. The present results, while they verified the significance of the ACC and CP in NOM- and MA-hyperactivity, also revealed a differential role of the ACC in NOM-hyperactivity and the CP in MA-hyperactivity.
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    EFFECT OF NOMIFENSINE AND METHAMPHETAMINE ON BRAIN CATECHOLAMINES LEVELS AND OPEN-FIELD ACTIVITY OF RATS
    (Singapore Univ Press Univ Singapore, 1994) ALKHATIB, I; FUJIWARA, M; DOKMECI, I
    The effects of i.p. injection of nomifensine (NOM) and methamphetamine (MA), singly and concomitantly, on ambulation and rearing in open-field test, and levels of catecholamines in nucleus accumbens (ACC) and caudate-putamen (CP) of rats were investigated. NOM at 5 and 10 mg kg(-1) increased the activity, whereas at 20 mg kg(-1) decreased it and produced in place repetitive head movements. NOM did not change catecholamines except at 20 mg kg(-1) it reduced norepinephrine in CP. MA at I and 3 mg kg(-1) increased the activity and at 3 mg kg(-1) reduced norepinephrine but elevated dopamine in CP. Concomitant injection of 20 mg kg(-1) of NOM with 3 mg kg(-1) of MA antagonized MA-induced hyperactivity and the increased levels of dopamine, whereas the in place activity and decreased level of norepinephrine in CP were still evident. NOM-hyperactivity seems to involve no significant effect on the levels of catecholamines in ACC or CP but the in place activities produced by the high dose of NOM (20 mg kg(-1)) seems to involve a decrease of norepinephrine in CP. MA-hyperactivity (at 3 mg kg(-1)) involved a decrease in norepinephrine and an increase in the level of dopamine in CP. The antagonizm of MA-hyperactivity by a high dose of NOM involved also antagonizm of MA-induced increase of dopamine in CP.