DSpace Arşivi :: by Yazar "Coşar-Alas R." değerine göre listeleniyor

Listeleniyor 1 - 1 / 1

Prevention of radiation-induced liver and kidney toxicity: A role for amifostine
(2007) U?uzalp-Kaldir M.; Yürüt-Çalo?lu V.; Coşar-Alas R.; Çermik T.F.; Altaner Ş.; Eskiocak S.; Saynak M.
Objectives: To investigate the protective effect of amifostine against radiation induced liver and kidney injury of rats, using scintigraphic and histopathologic parameters. Methods: Female Wistar Albino rats were randomly allocated to 3 groups: control, radiotherapy alone (RT), and amifostine+RT (n=10). Single-dose of 600 cGy X-ray was performed with a single field compromised liver and right kidney. Amifostine was administered intraperitoneally at a dose of 400 mg/kg, 30 minutes before irradiation. Scintigraphic evaluation was performed before irradiation and the end of the study at 6 nd month. Histopathologic examinations were performed post mortem. Results: A clear protective effect of amifostine against radiation-induced late damage in liver and kidney was found with scintigraphic evaluation. In addition, amifostine reduced the decrease of histopathologic changes for both of the tissues. Conclusion: The results showed that amifostine significantly reduced radiation-induced liver and kidney toxicity and therefore warrant additional study in a clinically relevant fractionated model.