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Öğe 99mTc-HMPAO labelled white blood cell scintigraphy in the diagnosis and monitoring of response of the therapy in patients with active bronchiectasis(Elsevier Science Inc, 2012) Altiay, G.; Cermik, T. F.Aim: The aim of this study was to assess the role of labelled leukocyte scintigraphy in the diagnosis and monitorization of response to therapy of patients with active bronchiectasis. Material and methods: Twenty patients underwent (99m)Technetium hexamethylpropyleneamine oxime (Tc-99m-HMPAO) labelled white blood cell (WBC) scintigraphy. A second scintigraphy was performed in 13 patients at 10 day of the treatment. Regional Tc-99m-HMPAO WBC uptake and radiologic imaging findings (high resolution computed tomography. or Chest X-Ray) in the lungs were classified into 3 categories in 6 lung areas. scintigraphic, radiological and clinical disease scores were calculated for all patients. Results: An abnormal accumulation was visually observed in 19 of 20 patients on the pre-treatment scans, the scintigraphy showing 95% sensitivity. A significant difference was found between early and late ratios (P=0.001) in the pre-treatment scans. The infected areas revealed a significant decrease in uptake ratios on the post-treatment scans compared to the pre-treatment scans (P=0.001). However, no significant correlation was determined between clinical and radiological scores, clinical and scintigraphic scores and also between scintigraphic and radiological scores (P >= 0.05). Conclusions: Tc-99m-HMPAO WBC scintigraphy may be a useful tool to evaluate response to therapy in patients with active bronchiectasis. (C) 2011 Elsevier Espana, S.L. and SEMNIM. All rights reserved.Öğe Assessment of alterations in regional cerebral blood flow in patients with hypothyroidism due to Hashimoto's thyroiditis(Springer, 2007) Kaya, M.; Cermik, T. F.; Bedel, D.; Kutucu, Y.; Tuglu, C.; Yigitbasi, Oe. N.Aim: The aim of this study was to assess regional cerebral blood flow (rCBF) using detailed semiquantative analysis of Tecnethium-99m hexamethylpropyleneamine (HMPAO) brain single-photon emission computered tomography (SPECT) in patients with hypothyroidism due to autoimmune thyroiditis. Patients, material and methods: Twenty patients (mean age: 42 +/- 9 yr) and 12 control subjects (mean age: 35.4 +/- 8.5 yr) were included in this study. The corticocerebellar rCBF ratios were obtained from 52 cerebral areas on 6 transaxial slices. By using control group rCBF ratios, lower reference values (RLV) (average ratio -2 SD) were calculated and the regions below RLV having an rCBF ratio were considered as abnormal decrease (hypoperfused) areas. Results: Significant reduced rCBF rates were measured for 15 (29%) cortical regions for the patient group. The areas in which significant reduced rCBF were demonstrated in the patient group were as follows: a) in the right hemisphere: superior frontal (slice 1 and 2), inferior frontal (slice 1), anterior temporal (slice 1 and 2), precentral gyrus (slice 1 and 2), postcentral gyrus (slice 1 and 2), and parietal cortex; b) in the left hemisphere: superior frontal (slice 1 and 2), inferior frontal (slice 1), caudate nucleus, and parietal cortex. The hypoperfusion was calculated in 154 (14%, 94 right and 60 left) cortical regions out of 1040 regions in the patient group. Conclusion: These findings indicate that the alteration of rCBF in patients with hypothyroidism due to Hashimoto's thyroiditis before T-4 therapy can be demonstrated with brain SPECT. Additionally, the degree of rCBF abnormalities could be determined with brain SPECT in patients with hypothyroidism due to Hashimoto's thyroiditis with or without neurologic or psychiatric symptoms.Öğe The assessment of the changes of regional cerebral blood flow using Tc-99m HMPAO SPET in patients with hyperparathyroidism(Springer, 2005) Cermik, T. F.; Kaya, M.; Ugur-Altun, H. B.; Bedel, D.; Berkarda, S.[Abstract Not Available]Öğe Monitoring of renal function using 99mTc-DMSA and 99mTc-DTPA scintigraphy in patients with spinal cord injury(Elsevier Doyma Sl, 2012) Tuna, H.; Cermik, T. F.; Tuna, F.Aim: The aim of this study was to assess the degree of alterations of renal function by using 99m-technetium dimercaptosuccinic acid (Tc-99m-DMSA) and 99m-technetium diethylenetriaminepentaacetic acid (Tc-99m-DTPA) scintigraphy in spinal cord injury (SCI) patients. Material and methods: Twenty-two consecutive SCI (15 paraplegic and 7 tetraplegic) patients (mean age: 49.1 +/- 13.4 years) who had no urinary symptoms participated in this prospective study. The mean duration of injury was 45.6 +/- 48.8 months before. Sixteen patients had at least one urinary tract infection history. Renal cortical scintigraphy with Tc-99m-DMSA, radionuclide renography with Tc-99m-DTPA and renal ultrasound were performed within 2-week period. Results: Four (18%) patients had serious pathology on their kidneys such as unilateral or bilateral parenchymal scarring and increased background uptake in their renal cortical scintigraphy with Tc-99m-DMSA. Two of them had grade 3-4 pelvicaliceal ectasia on ultrasound. Additionally, 2 of 18 remaining patients had grade 2 pelvicaliceal ectasia on ultrasound. Sixteen (73%) patients had markedly delayed or delayed and decreased functions of one or both of kidneys on radionuclide renography. However, only four patients had grade 2-4 pelvicaliceal ectasia and none of them had a finding of loosening of renal parenchyma. Conclusion: Combined use of renal cortical scintigraphy and radionuclide renography appears to be contributive to renal ultrasound in the long-term follow-up of patients with SCI. Patients with abnormal findings should be closely followed, and early therapeutic interventions may enable lower morbidity and mortality rates in these patients. (C) 2011 Elsevier Espana, S.L. and SEMNIM. All rights reserved.
