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Öğe I-123 MIBG scintigraphy in the detection of amiodarone induced pulmonary toxicity(Springer-Verlag, 2001) Altun, GD; Altun, A; Salihoglu, YS; Sankaya, A; Özbay, G; Berkarda, S[Abstract Not Available]Öğe Irbesartan has a masking effect on dipyridamole stress induced myocardial perfusion defects(Lippincott Williams & Wilkins, 2004) Altun, GD; Altun, A; Yildiz, M; Firat, MF; Hacimahmutoglu, S; Berkarda, SBackground and aim The angiotensin 11 type 1 (AT(1)) receptor antagonist irbesartan is used for the treatment of hypertension, but its anti-ischaemic effect is not yet known. Our aim was to assess the effect of irbesartan administration on the diagnostic yield of Tc-99m sestamibi single photon emission computed tomography (SPECT) in patients with coronary artery disease (CAD) after dipyridamole stress. Methods Our study group consisted of 13 patients (11 men and two women; mean age, 53.3 +/- 10.6 years; body mass index, 26.9 +/- 3.3 kg.m(-2)) with angiographically documented CAD. All patients underwent Tc-9m sestamibi SPECT studies at rest, before (STRESS-1) and 2 weeks after irbesartan (150 mg daily) administration (STRESS-2) at dipyridamole stress. The extent and severity of defects were analysed by using visual and quantitative Tc-99m sestamibi SPECT. Results The mean summed stress score was significantly higher during the STRESS-1 study than the STRESS-2 study (13.2 +/- 7.4 vs. 11 +/- 74, P=0.003). The mean size of perfusion defects at stress was significantly larger for the STRESS-1 group than the STRESS-2 group (17.8% +/- 2.85% vs. 15.3% +/- 2.95%, P=0.01). Conclusion Our study showed that the AT(1) receptor blocker irbesartan reduces the extent and severity of Tc-99m sestamibi perfusion defects after dipyridamole stress in patients with CAD. Irbesartan may alter coronary blood flow reserve. The continued use of irbesartan before stress myocardial perfusion SPECT has a masking effect on stress induced myocardial perfusion defects. For this reason AT(1) receptor blockers must be stopped before stress myocardial perfusion scintigraphic examinations. (C) 2004 Lippincott Williams Wilkins.Öğe Prevalence of the female athlete triad in Edirne, Turkey(Journal Sports Science & Medicine, 2005) Vardar, SA; Vardar, E; Altun, GD; Kurt, C; Öztürk, LThe aim of this study was to determine the prevalence of the female athlete triad, which is a clinical condition defined as the simultaneous occurrence of disordered eating, amenorrhea, and osteopenia and/or osteoporosis in female athletes. A total number of 224 female athletes from Edirne city participated in our study. Eating attitudes test ( EAT 40) and a self-administered questionnaire were used to assess disordered eating behavior and menstrual status respectively. The participants having both disordered eating and amenorrhea were performed dual energy x-ray absorptiometry to evaluate bone mineral density. Thirty seven subjects (16.8%) had disordered eating behavior and 22 subjects (9.8%) were reported to have amenorrhea. Six athletes (2.7%) met two criteria ( disordered eating and amenorrhea) of the triad. Of these, only three athletes met all components of the triad. We have found that the prevalence rate of female athlete triad was 1.36% among young Turkish female athletes. Female athletes have under considerable risk for the disordered eating and amenorrhea components of the triad.Öğe Tc-99m MIBI filling pattern in a photopenic area of a Tc-99m MDP scan in a patient with metastatic bone involvement of breast carcinoma(Lippincott Williams & Wilkins, 2002) Altun, GD; Uzal, C; Hacimahmutoglu, S; Pekindil, G; Sarikaya, A; Yigitbasi, NÖA 71-year-old woman had locally advanced invasive breast cancer in July 1997. She underwent modified radical mastectomy for left breast cancer in October 1997 after she had been treated with six of courses neoadjuvant chemotherapy and local radiation therapy. She was referred for bone scintigraphy due to bone pain in September 1999. The bone scan showed metastatic involvement in the left temporoparietal area as increased Tc-99m MDP uptake with large central photopenia. The computed tomographic (CT) scan of the cranium revealed lytic bone lesions located in the same region, which was irregularly contoured. Tc-99m MIBI imaging was performed 1 week after the bone scan. Increased uptake without central photopenia was observed in the same area as the bone scan abnormality. It was described as a Tc-99m MIBI filling pattern of the photopenic area seen with Tc-99m MDP.Öğe Tc99m MIBI scintigraphy in metastatic bone involvement of breast cancer(Springer-Verlag, 2001) Altun, GD; Uzal, C; Hacimahmutoglu, S; Pekindil, G; Sarikaya, A[Abstract Not Available]Öğe Technetium-99m sestamibi cavity/myocardium count ratio in the detection of left ventricular hypertrophy(Clinical Cardiology Publ Co, 2003) Altun, GD; Akdemir, O; Ustun, F; Altun, A; Sarikaya, A; Berkarda, SBackground and hypothesis: Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular mortality and morbidity. This study was designed to assess whether technetium-99m (Tc-99m) sestamibi cavity-to-myocardium count (c/m) ratio would differentiate LVH from normal geometry, and discriminate between the two patterns-concentric and eccentric-of LVH. Methods: In all, 72 patients including 32 hypertensive patients with both normal Tc-99m sestamibi single-photon emission computed tomography imaging and good-quality echocardiographic recordings were studied retrospectively. Four different patterns of left ventricular (LV) geometry were defined: normal (n = 47), concentric remodeling (n = 3), eccentric LVH (n = 13), and concentric LVH (n = 9). Results: Left ventricular hypertrophy was detected in 22 of 32 hypertensive patients. The c/m ratio calculated on midventricular short-axis slices of dipyridamole-stress Tc-99m sestamibi images was significantly decreased in patients with LVH compared with subjects with normal geometry (0.05 +/- 0.02 vs. 0.17 +/- 0.08, p = 0.001). A c/m ratio of < 0.124 yielded a sensitivity of 86%, a specificity of 64%, and an overall diagnostic accuracy of 68% for detecting LVH. Negative correlations of c/m ratio were found to LV mass-index (r = -0.44, p = 0.004), septal width (r = -0.42, p = 0.008), posterior wall thickness (r = -0.39, p = 0.001), and relative wall thickness (r = -0.40, p = 0.001). Multiple linear regression analysis revealed that LV mass index was the single independent predictor of c/m ratio. Although both groups with concentric and eccentric LVH had a significantly lower mean c/m ratio than those with normal geometry (p = 0.01 and p = 0.01, respectively), no significant difference of c/m ratio was found between the two patterns of LVH. Conclusion: A new index, c/m ratio on Tc-99m sestamibi images, has a potential to discriminate between LVH and normal geometry in subjects free of myocardial ischemia.Öğe Ventricular repolarization changes during thyrotropin releasing hormone test(Elsevier Sci Ireland Ltd, 2001) Altun, A; Ugur, B; Akdemir, O; Altun, GD; Öztekin, E; Birsin, A; Özbay, GWe investigated the ventricular repolarization changes during thyrotropin-releasing hormone (TRH) test in 20 euthyroid healthy subjects. TSH elevation was observed in 14 subjects (age: 29 +/- 5 years). TSH increased at 20 min (baseline: 1.91 +/- 1.18 muU/ml vs. 20 min: 13.7 +/- 7.2 muU/ml, P < 0.0001) and slightly decreased at 40 min (baseline vs. 40 min: 11.6 6.7 muU/ml P < 0.0001). Many dispersions prolonged at 20 and 40 min (P < 0.05). At baseline, 20 and 40 min, positive linear correlations were observed between TSH levels and TTd and TTcd, These data shows: that ventricular repolarization and regional inhomogeneity of ventricular repolarization increase during the TRH test. Neural and receptor-mediated mechanisms on repolarization kinetics of myocardial cells may act on this effect. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
