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    MEFV Gene Exon 2 and Exon 10 Gene Region Mutations of Familial Mediterranean Fever Patients in Trakya Population
    (Aves Yayincilik, Ibrahim Kara, 2010) Gurkan, Hakan; Ozkayin, Emine Nese; Tabakcioglu, Kiymet; Algunes, Cetin
    Objectives: The objective of the study is to explore the MEFV gene exon 2 and exon 10 gene region mutations which take place in etiopathogenesis of Familial Mediterranean Fever in the Thrace population with the DNA sequence analysis method and to compare the results with the other studies. Patients and Methods: The study included patients with Familial Mediterranean Fever who have no relative relationship, have the same linguistic characteristic and live in the Thrace region for at least three generations (34 females, 34 males). MEFV gene exon 2 and exon 10 gene regions multiplied with PCR and their nucleotids were determined with the DNA sequence analysis method. Results: G442C, T306C, A414G, C495A, G605A SNPs were found in MEFV gene exon 2 gene region and G20400, A2080G, 02082A, A2084G, T2177C, G2282A SNPs were found in MEFV gene exon 10 gene region in the Thrace population. Conclusion: The T306C, A414G, C495A, G605 single-nucleotide polymorphisms in MEFV gene exon 2 gene region and the mutations in exon 10 gene region are not compatible in terms of their frequencies with the results of the other studies.
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    Positive Mixed lymphocyte Culture Test Result Due to HLA-DP Mismatch
    (Galenos Publ House, 2011) Ayna, Tulay Kilicaslan; Tozkir, Hilmi; Ciftci, Hayriye Senturk; Gurkan, Hakan; Tekgunduz, Emre; Algunes, Cetin; Gurtekin, Mehmet
    Graft Versus Host Disease (GVHD) remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (SCT). The MLC assay has been generally accepted as a standard test for determining HLA-D region compatibility. In this study, the MLC test has been carried out on the related recipient-donor couple who were prepared for allogeneic SCT and were found to be matched for HLA-A, -B, -Cw, DR, DO but not for -DP. The result of the MLC test was positive. We observed that HLA-DP mismatch was responsible for the increased proliferation values in MLC test.