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Öğe Anaplastic variant of diffuse large B-cell lymphoma associated with cutaneous fistulas; an unusual presentation(Zerbinis Medical Publ, 2014) Pamuk, Gulsum Emel; Tasci, Murat; Uyanik, Mehmet Sevki; Akker, Mustafa; Puyan, Fulya Oz[Abstract Not Available]Öğe Clinical Features and Types of Articular Involvement in Patients with Psoriatic Arthritis(Clinical & Exper Rheumatology, 2014) Donmez, Salim; Pamuk, Omer Nuri; Akker, Mustafa; Ak, Recep[Abstract Not Available]Öğe Clinical features and types of articular involvement in patients with psoriatic arthritis(Springer London Ltd, 2015) Donmez, Salim; Pamuk, Omer Nuri; Akker, Mustafa; Ak, RecepPsoriatic arthritis (PsA) is a psoriasis-associated inflammatory arthritis which causes joint destruction. There are some epidemiologic data about PsA; however, there are no sufficient data from Turkey. Herein, we evaluated the frequency of PsA in the Thrace region of Turkey according to hospital-based data. In addition, we evaluated clinical features and types of joint involvement in PsA patients. We included 172 PsA patients fulfilling CASPAR criteria admitted to the Division of Rheumatology, Trakya University Medical Faculty, between 2003 and 2012. Data from Turkish Statistical Institution was used to calculate the incidence and prevalence of PsA. Patients' demographic features, durations of psoriasis and PsA, number of tender and swollen joints, treatment modalities, laboratory data, and X-ray film findings were recorded from hospital files. The annual incidence of PsA was 2.8/100,000. The mean annual incidence was 3.47/100,000 in females and 2.15/100,000 in males. The overall prevalence of PsA in our region was 27.9/100,000 (95 % confidence interval (CI) 23.7-32.1) in individuals > 16 years. The prevalence of PsA was higher in females than in males (34.7/100,000 vs. 21.5/100,000). Polyarthritis was present in 67 (38.9 %), oligoarthritis in 47 (27.3 %), spondyloarthritis in 39 (22.6 %), and distal interphalangeal (DIP) arthritis in 19 (11.0 %) patients. The duration of psoriasis was significantly longer in polyarticular PsA patients than in DIP and oligoarticular groups (p values = 0.016 and 0.018, respectively). The number of swollen joints correlated with age (r = 0.21, p = 0.006), duration of psoriasis (r = 0.20, p = 0.01), number of tender joints (r = 0.92, p a parts per thousand currency signaEuro parts per thousand 0.001), ESR (r = 0.24, p = 0.001), and CRP (r = 0.17, p = 0.026). The frequency of PsA in Thrace region is similar to that in low-frequency regions. The most frequent type of involvement was polyarticular, and it correlated with the duration of psoriasis and erosive disease.Öğe Diferansiye tiroid kanserlerinde insülin direnç gen polimorfizmlerinin araştırlması(Trakya Üniversitesi Tıp Fakültesi, 2012) Akker, Mustafa; Güldiken, SibelTiroid kanserleri endokrin malignensiler içerisinde en sık gözlenen malignensidir. Çoğunluğu tiroid folliküler hücrelerden köken alan, iyi diferansiye folliküler ve papiller tiroid kanserlerinden oluşur. Tiroid kanserinin patogenezinde diğer kanserlerde olduğu gibi genetik değişimler ve bazı çevresel faktörler temel rol oynamaktadır. Bu nedenle birçok solid tümör patogenezinde rolü olduğu düşünülen, ayrıca diferansiye tiroid kanserli hastalarda şu ana kadar çalışılmamış olan insülin reseptör substrat-1, insülin reseptör substrat-2 ve insülin benzeri büyüme faktörü bağlayıcı protein-3 genotiplerinin tiroid kanseriyle olan ilişkisini incelemek, ayrıca obezite ve insülin direnci gibi bazı çevresel faktörlerin diferansiye tiroid kansere olan etkisini araştırmayı amaçladık. Çalışmaya diferansiye tiroid kanser tanısı olan 93 hasta (79 kadın, 14 erkek) ve 111 sağlıklı kontrol olgusu (63 kadın, 48 erkek) alındı. Tüm olguların antropometrik ölçümleri, insülin direnci göstergesi olan homeostatik model değerlendirme sonuçları, lipidleri, tiroid fonksiyon testleri kaydedildi. Ayrıca insülin reseptör substrat-1, insülin reseptör substrat-2 ve insülin benzeri büyüme faktörü bağlayıcı protein-3 gen polimorfizmleri polimeraz zincir reaksiyonu ve restriksiyon fragmant uzunluk polimorfizmi yöntemleri kullanılarak belirlendi. Diferansiye tiroid kanserli olguların insülin direnci göstergesi olan homeostatik model değerlendirme sonuçları, vücut kitle indeksi, bel çevresi ve kolesterol düzeyleri kontrol grubuna nazaran daha yüksek saptandı. Diferansiye tiroid kanserli hastalarla kontrol grubu arasında açlık kan glukoz, insülin, trigliserid düzeyleri ile Diabetes Mellitus tanısı olanların sayısı açısından fark izlenmedi. İnsülin reseptör substrat-1, insülin reseptör substrat-2 ve insülin benzeri büyüme faktörü bağlayıcı protein-3 polimorfizm sıklığı; diferansiye tiroid kanserli hastalar ile sağlıklı olgular arasında farklı değildi. Ayrıca bu polimorfizmlerin; lenf bezi metastazı ve tümör evrelemesine etkisi olmadığı gözlendi. Diferansiye tiroid kanser patogenezinde; insülin reseptör substrat-1, insülin reseptör substrat-2 ve insülin benzeri büyüme faktörü bağlayıcı protein-3 polimorfizmlerinin rol oynamadığını saptadık. Ancak diferansiye tiroid kanser gelişiminde; obezite, insülin direnci göstergesi olan homeostatik model değerlendirme sonuçları artışının, ileri yaş ve kadın cinsiyetin önemli olduğunu tespit ettik.Öğe Investigation of insulin resistance gene polymorphisms in patients with differentiated thyroid cancer(Springer, 2014) Akker, Mustafa; Guldiken, Sibel; Sipahi, Tammam; Palabiyik, Orkide; Tosunoglu, Ayhan; Celik, Ozlem; Tuncbilek, NerminWe aimed to investigate insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2), insulin-like growth factor binding protein-3 (IGFBP-3) genotypes, which are thought to be involved in the pathogenesis of many solid tumors and have thus far not been studied in patients with differentiated thyroid cancer (DTC). The study consisted of 93 patients diagnosed with DTC (79 females, 14 males) and 111 healthy control subjects (63 females, 48 males). The anthropometric measurements, lipid profiles, thyroid function tests and homeostatic model assessment (HOMA) as an indicator of insulin resistance (IR) of all patients were recorded. In addition IRS-1, IRS-2 and IGFBP-3 gene polymorphisms were determined by using polymerase chain reaction and restriction fragment length polymorphism. Hardy-Weinberg equilibrium was tested for each gene polymorphisms, and genetic effects were evaluated by the Chi Square test and multiple logistic regression. Homeostasis model assessment of insulin resistance (HOMA-IR), body mass index, waist circumference and serum total cholesterol levels were significantly higher in patients with DTC than in the control group. There was no difference between the two groups with respect to IRS-1, IRS-2 and IGFBP-3 gene polymorphisms. In addition, these gene polymorphisms were found to have no effect on lymph node metastases or tumor staging. While, obesity and increased HOMA-IR may be risk factors in DTC development, we suggest that IRS-1, IRS-2 and IGFBP-3 gene polymorphisms do not play an important role in pathogenesis of DTC.Öğe Investigation of VEGF and IL-8 Gene Polymorphisms in Patients with Differentiated Thyroid Cancer(Clin Lab Publ, 2016) Kilic, Ilhan; Guldiken, Sibel; Sipahi, Tammam; Palabiyik, Orkide; Akker, Mustafa; Celik, Ozlem; Soysal-Atile, NeslihanBackground: Differentiated thyroid carcinomas (DTC) account for most of the thyroid cancers. The emergence of DTC may be affected by various predisposing genetic alterations and environmental factors The aim of this study was to investigate the role of VEGF C936T and IL-8 A251T gene polymorphisms in the pathogenesis and metastasis of differentiated thyroid cancer. Methods: The study consisted of 101 patients DTC patients and 109 healthy controls. The parameters of the stage of cancer of the DTC patients at the time of diagnosis (TNM) were recorded. DNA was isolated from blood using a DNA isolation kit. VEGF C936T and IL-8 A251T gene polymorphisms were determined using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Distributions of gene polymorphisms were evaluated according to the Hardy-Weinberg principle. Results: The TT genotype from the VEGF C936T genotype distributions was higher in the control group than in the DTC group (p < 0.05). In contrast, the IL-8 A-251T genotype distributions were similar in both groups. No relationship was found between either cytokine gene polymorphism or the DTC stages. The frequency of IL-8 TT was higher in the DTC group with lymph gland metastasis (TT 92%) than in the group without lymph gland metastasis (TT 45.9%) (p < 0.05). Conclusions: We consider that the VEGF 936 TT genotype may play a protective role in the development of DTC and that the IL-8 A-251 TT genotype may contribute to the DTC lymph node metastasis. Therefore, these genotypes may hold a key to the evaluation of thyroid nodules and the metastasis of DTC.Öğe Is iron-deficiency anemia associated with migraine? Is there a role for anxiety and depression?(Springer Wien, 2016) Pamuk, Gulsum Emel; Top, Mehmet Serif; Uyanik, Mehmet Sevki; Koker, Hilal; Akker, Mustafa; Ak, Recep; Yurekli, Omer AtalayIn this study, we determined the frequency of migraine headache in iron-deficiency anemia (IDA) patients and whether it was related to anxiety, depression, and somatization. We included 127 consecutive IDA patients into the study. All patients were asked validated questions about headache and migraine face-to-face. They were administered validated questionnaires for anxiety-depression The Hospital Anxiety and Depression Scale and somatization. The quality of life (QoL) disturbance associated with headache was marked on a 0-10 VAS. Of all IDA patients, 79.5 % defined headache at any time of their life. In addition, 36.2 % of all IDA patients defined the criteria for migraine. IDA patients with migraine were more frequently smokers and had significantly lower hemoglobin and mean corpuscular volume values (p values < 0.05). The IDA group with migraine had significantly higher mean anxiety score (p = 0.046) and headache-related QoL disturbance score (p = 0.021) than the IDA group without migraine. Migraine patients with aura had lower hemoglobin values (p = 0.02), higher depression scores (p = 0.005), and higher migraine-related QoL disturbance scores than others. IDA patients have a high frequency of migraine headache. The presence of anxiety and depression have great influence on the presence of migraine in IDA patients.Öğe Is JAK2V617F Mutation the Only Factor for Thrombosis in Philadelphia-Negative Chronic Myeloproliferative Neoplasms?(Springer India, 2016) Uyanik, Mehmet Sevki; Baysal, Mehmet; Pamuk, Gulsum Emel; Maden, Muhammet; Akker, Mustafa; Umit, Elif Gulsum; Demir, MuzafferThe most common genetic disorder in Philadelphia negative chronic myeloproliferative neoplasms is the JAK2-V617F mutation. In the present study, we aimed to determine risk factors for thrombosis in patients with essential thrombocytosis and polycythemia vera. We screened the medical records of 101 patients. Risk factors which may predict thrombosis were recorded. Venous thrombosis (VT) before diagnosis was significantly higher in JAK2 positive patients. VT after diagnosis was similar in JAK2 positive and negative groups, and was significantly higher in elderly patients. Treatment places importance on the JAK2 mutation under unmodifiable cardiovascular risk factors such as advanced age after diagnosis.
