Is JAK2V617F Mutation the Only Factor for Thrombosis in Philadelphia-Negative Chronic Myeloproliferative Neoplasms?
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer India
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The most common genetic disorder in Philadelphia negative chronic myeloproliferative neoplasms is the JAK2-V617F mutation. In the present study, we aimed to determine risk factors for thrombosis in patients with essential thrombocytosis and polycythemia vera. We screened the medical records of 101 patients. Risk factors which may predict thrombosis were recorded. Venous thrombosis (VT) before diagnosis was significantly higher in JAK2 positive patients. VT after diagnosis was similar in JAK2 positive and negative groups, and was significantly higher in elderly patients. Treatment places importance on the JAK2 mutation under unmodifiable cardiovascular risk factors such as advanced age after diagnosis.
Açıklama
Anahtar Kelimeler
Chronic Myeloproliferative Neoplasms, JAK2 Mutation, Allele Burden, Thrombosis, Jak2 V617f Mutation, World-Health-Organization, Essential Thrombocythemia, Polycythemia-Vera, High-Risk, Allele Burden, Hydroxyurea, Disease, Transformation, Jak2(V617f)
Kaynak
Indian Journal Of Hematology And Blood Transfusion
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
32
Sayı
3