Is JAK2V617F Mutation the Only Factor for Thrombosis in Philadelphia-Negative Chronic Myeloproliferative Neoplasms?

Küçük Resim Yok

Tarih

2016

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Springer India

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

The most common genetic disorder in Philadelphia negative chronic myeloproliferative neoplasms is the JAK2-V617F mutation. In the present study, we aimed to determine risk factors for thrombosis in patients with essential thrombocytosis and polycythemia vera. We screened the medical records of 101 patients. Risk factors which may predict thrombosis were recorded. Venous thrombosis (VT) before diagnosis was significantly higher in JAK2 positive patients. VT after diagnosis was similar in JAK2 positive and negative groups, and was significantly higher in elderly patients. Treatment places importance on the JAK2 mutation under unmodifiable cardiovascular risk factors such as advanced age after diagnosis.

Açıklama

Anahtar Kelimeler

Chronic Myeloproliferative Neoplasms, JAK2 Mutation, Allele Burden, Thrombosis, Jak2 V617f Mutation, World-Health-Organization, Essential Thrombocythemia, Polycythemia-Vera, High-Risk, Allele Burden, Hydroxyurea, Disease, Transformation, Jak2(V617f)

Kaynak

Indian Journal Of Hematology And Blood Transfusion

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

32

Sayı

3

Künye