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    Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives
    (Slovensko Kemijsko Drustvo, 2018) Akcay, Sevilay; Ulger, Mahmut; Onurdag, Fatma Kaynak; Dundar, Yasemin
    In this study, new pyrido [3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl) pyrido [3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido [3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.