Dubus, TurkanCelik, GurhanHuq, GulbenTopacoglu, HakanDuzyol, CagriOzoran, Emre2024-06-122024-06-1220140393-63842283-9720https://hdl.handle.net/20.500.14551/19649Aims: The aim of this study was to assess the effects of cepae extractum-heparin on the prevention of pleural adhesions following thoracotomy in rats. Methods: 20 female Sprague-Dawley rats were used in this study. The rats were randomized into three groups. group I underwent only a thoracotomy. Animals in group 2 underwent thoracotomy with pleural abrasion, and animals in group 3 underwent thoracotomy with pleural abrasion and were treated with intrapleural application of cepae extractum-heparin-allantoin. The animals were sacrificed on the twenty-first day, and the adhesions were evaluated both microscopically and macroscopically. Results: The mean adhesion severity scores for groups 1, 2, and 3 were 1.25 +/- 0.50, 2.6 2 +/- 1.41 and 1.25 +/- 0.46, respectively. While there were no significant differences in the length of adhesions between group 1 and 2 (p>0.05), the difference was significant between groups I and 3, and also between 2 and 3 (p<0.05 for both). Comparison of the groups with respect to the adhesion severity score showed that there were no statistically significant differences between the groups (p>0.05). The difference between the groups with respect to thicknesses of the parietal and visceral pleurae showed no significant difference (p>0.05). Conclusion: The results showed that the use of cepae extractum-heparin-allantoin following thoracotomy decreased the pleural adhesions, however this decrease was not statistically significant.eninfo:eu-repo/semantics/closedAccessCepae Extractum-Heparin-AllantoinAdhesionPleuraRatReductionArticle303665671Q4WOS:000344634100019