Arisoy, ArifTopcu, SelimDemirelli, SelamiAltunkas, FatihKarayakali, MetinCelik, AtacTanboga, Ibrahim Halil2024-06-122024-06-1220162149-22632149-2271https://doi.org/10.5152/AnatolJCardiol.2015.6622https://search.trdizin.gov.tr/yayin/detay/223731https://hdl.handle.net/20.500.14551/24320Objective: The aim of this study was to evaluate right ventricle (RV) functions using echocardiography in healthy subjects who migrated from the sea level to moderate altitude (1890 m). Methods: The prospective observational in this study population consisted of 33 healthy subjects (23 men; mean age 20.4 +/- 3.2 years) who migrated from the sea level to a moderate altitude (Erzurum city centre, 1890 m above sea level) for long-term stay. Subjects underwent echocardiographic evaluation within the first 48 h of exposure to the moderate altitude and at the sixth month of arrival. Conventional echocardiographic parameters such as RV sizes and areas, systolic, and diastolic functional indices [fractional area change (FAC), tricuspid flow velocities, myocardial performance index (MPI), and tricuspid annular plane systolic excursion (TAPSE)] were obtained. Systolic (S) and diastolic (E', A') velocities were acquired from the apical four-chamber view using tissue Doppler imaging. Kolmogorov-Smirnov test, student's t-test, Wilcoxon test, and chi-square test were used in this study. Results: There were no significant changes in RV size, FAC, MPI, TAPSE, inferior inspiratory vena cava collapse, tricuspid E velocity, and tricuspid annulus E' velocity. Compared with the baseline, there was a significant increase in mean pulmonary artery pressure (p=0.001); RV end systolic area (p=0.014); right atrial end diastolic area (p=0.021); tricuspid A velocity (p=0.013); tricuspid annulus S and A' velocity (p=0.031 and p=0.006, respectively); and RV free wall S, E', and A' velocity (p=0.007, p<0.001, and p=0.007 respectively) at the sixth month. Also, there was a significant decrease in tricuspid E/A ratio (1.61 +/- 0.3 vs. 1.45 +/- 0.2, p=0.038) and tricuspid annulus E'/A' ratio (1.52 +/- 0.5 vs. 1.23 +/- 0.4, p=0.002) at the sixth month. Conclusion: Our study revealed that right ventricular diastolic function was altered while the systolic function was preserved in healthy subjects who migrated from the sea level to a moderate altitude.en10.5152/AnatolJCardiol.2015.6622info:eu-repo/semantics/openAccessTissue DopplerRight VentricleHigh AltitudePulsed Doppler-EchocardiographyPulmonary-Artery PressureChronic Mountain-SicknessCardiac AdaptationHeartHypertensionHighlandersDiseaseMetersArticle1610779783Q4WOS:0003921958000122-s2.0-8499424643927271474Q3223731