Zeren, UgurSonmez, Mehmet BulentVardar, Erdal2024-06-122024-06-1220111017-7833https://doi.org/10.5455/bcp.20110415053520https://hdl.handle.net/20.500.14551/18255Objective: Alcohol dependence doesn't develop in all individuals consuming alcohol; therefore risk factors for dependence, its etiology, and the bases of the urge to drink alcohol should be investigated. As hormones have different functions in the body, they have been among the subjects of research to determine these factors. Especially the hormones affecting food intake could be thought to have a relationship with alcohol consumption. The aim of this study was to investigate whether the hormones affecting food intake play a role in alcohol dependence. Method: Twenty-one patients were included in the study. All patients were referred to and hospitalized in the Department of Psychiatry, Trakya University School of Medicine. They were clinically evaluated and diagnosed with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) criteria. Fasting blood samples were collected at 08:00 AM on the first day of hospitalization, which was also the day the patients gave up drinking (day 0), and then on the following 1(st), 7(th), and 28(th) days to measure ghrelin, leptin, and prolactin levels. Twenty one healthy volunteers (20 males, 1 female), who had not consumed any alcohol for at least ten days and did not meet the criteria for alcohol dependence based on the DSM-IV, were included in this study. Blood samples were collected from the control group for determination of levels of ghrelin, leptin, and prolactin. Results: There were no significant differences between the alcohol dependent patient group and the healthy control group regarding leptin, ghrelin or prolactin levels. Additionally, there were no significant differences between the leptin and prolactin levels on day 0, 1, 7, and 28 in the patient group. A statistically significant decrease was found in ghrelin levels of alcohol dependent patients between the days of 0 and 28 and between the days of 1 and 28. Conclusions: Because of the decline in the ghrelin levels on day 28 compared to day 0 and 1, there is a need for further studies on alcohol dependent patients. The evaluation of more prolonged sobriety days may also be useful. This study did not support the hypothesis that leptin, ghrelin, and prolactin levels are a biological indicator for alcohol dependence.tr10.5455/bcp.20110415053520info:eu-repo/semantics/openAccessAlcohol DependenceLeptinGhrelinProlactinNecrosis-Factor-AlphaSerum-LevelsWithdrawalArticle212122130Q4WOS:0002943990000062-s2.0-79961113920N/A