Yesilyurt, FatmaYuca, HafizeKarakaya, SongulTekman, EnesDemirci, BetulTaghizadehghalehjoughi, AliGoger, Gamze2024-06-122024-06-1220231041-29052163-8152https://doi.org/10.1080/10412905.2023.2234372https://hdl.handle.net/20.500.14551/24602In this study, leaf essential oil effects on glutamate toxicity model formed in cortex neurons and LN405 cell cultures were investigated. Antidiabetic activity was evaluated by & alpha;-amylase and & alpha;-glucosidase inhibitions. MIC was used for antimicrobial activity. Seven groups were examined with MTT. Glutamate 10-5 mM in cortex showed 62% viability whereas oil viability did not increase in a dose-dependent manner and the highest viability rate was observed. There are four types of glandular trichomes in leaf anatomy of walnut. The oil exhibited half as much & alpha;-glucosidase inhibitory activity with an IC50 value of 8105 & mu;g/mL, compared to positive control acarbose (IC50 = 4762 & mu;g/mL). MIC of oil was determined to be 625 & mu;g/mL against E. coli, C. albicans, and C. parapsilosis, whereas S. aureus exhibited a MIC of 1250 & mu;g/mL. Major compounds of oil were found as & beta;-pinene (17.6%), & alpha;-pinene (11.3%), & beta;-eudesmol (8.6%), and caryophyllene oxide (6.2%).en10.1080/10412905.2023.2234372info:eu-repo/semantics/closedAccessWalnutJuglans RegiaLN405GlutamateAntidiabeticAntimicrobial>Juglans-Regia L.Volatile OilAntioxidantLeavesNigraArticle354372381N/AWOS:0010227719000012-s2.0-85164718552Q2