Ozyurt, AnilElmas, CigdemSeymen, Cemile MervePeker, Veysel TuncayAltunkaynak, BulentGungor, Mehmet Nadir2024-06-122024-06-1220180278-23911531-5053https://doi.org/10.1016/j.joms.2017.10.014https://hdl.handle.net/20.500.14551/24762Purpose: This study investigated the effect of a gallium-aluminum-arsenide (GaAlAs) diode laser used in low-level laser therapy (LLLT) with the application of Mecsina Hemostopper on mandibular alveolar bone healing. Materials and Methods: Standard semispherical bone defects were created in left mandibular diastema sites of 32 female Long-Evans rats. Experimental animals were allocated to 1 of 4 groups: control group (no treatment), laser group (GaAlAs LLLT), Mecsina group, and laser-Mecsina combination group. Liquid Mecsina 0.01 mL was applied to the bone defects. Laser treatment was performed for 7 days after surgery at an energy dose of 10 J/cm(2). All animals were sacrificed to observe hard tissue healing histologically, immunohistochemically, and radiologically at 30 days after surgery. Results: Histologic assessment showed significantly more calcified tissue areas and significantly more osteoblast cells in the laser and laser-Mecsina groups than in the other groups (P <.01). Qualitative morphologic assessment showed that more bone tissue was present in the laser-Mecsina group than in the other groups. Conclusion: This study showed that LLLT, Mecsina application, and combined treatments were effective in healing alveolar bone among all tested treatment modalities. (C) 2017 American Association of Oral and Maxillofacial Surgeonsen10.1016/j.joms.2017.10.014info:eu-repo/semantics/closedAccessAnkaferd Blood StopperPlatelet-Rich PlasmaCritical-SizeIn-VitroRatsGrowthEnhancementMacrophagesIrradiationFracturesArticle762Q2WOS:0004234592000102-s2.0-8503705202829125929Q2