Cevik, GokhanTozsin, AtincTastekin, EbruDursun, MuratAktoz, TevfikKadioglu, Ates2024-06-122024-06-1220231022-386X1681-7168https://doi.org/10.29271/jcpsp.2023.11.1217https://hdl.handle.net/20.500.14551/18551Objective: To investigate the anti-fibrotic effects of pirfenidone on Peyronie's disease in an experimental rat model with intracavernosal injection of TGF-ss and whether pirfenidone improves erectile function. Study Design: Experimental study. Place and Duration of the Study: Faculty of Medical Experimental Animals and Research Laboratory, Trakya University, from January to March 2021. Methodology: In this study, 27 male Sprague Dawley rats were used, and three groups were randomly identified. The rats in Group 1 served as the control group. Group 2 was not treated, and Group 3 was treated with pirfenidone therapy. The rats in Group 3 were administered pirfenidone 30 mg/kg/day by oral gavage, every day for four weeks, three weeks after the start of the experiment. At the end of seven weeks, a haemodynamic study was performed with cavernosal nerve stimulation to evaluate the erectile function, the rats were sacrificed, and the penile tissues were evaluated immunohistochemically. Results: MeICP/MIBP values were found to be higher in treated rats compared to rats in the untreated group but no statistically significant difference was found in MeICP/MIBP values between the control, Peyronie model, and treatment groups (p=0.25). According to the histopathological examination, the rate of fibrosis with H&E staining was mild (100%) in the control group, severe (100%) in the Peyronie group, and severe (87.5% severe and 12.5% moderate) in the Peyronie + treatment group. Conclusion: In the study, pirfenidone used in the treatment of Peyronie's disease had a positive effect on erectile function, though not considered statistically significant. It has been shown that it has no histopathological effect on Peyronie's plaques.en10.29271/jcpsp.2023.11.1217info:eu-repo/semantics/openAccessAnti-Fibrotic AgentErectile FunctionExperimental StudyPeyronie's DiseasePirfenidoneAnimal-ModelDiseaseProliferationFibroblastsColchicineArticle331112171222N/AWOS:0011501989000022-s2.0-8517632095837926870Q3