Kucuk, MOkman, TK2024-06-122024-06-1220050015-0282https://doi.org/10.1016/j.fertnstert.2004.05.100https://hdl.handle.net/20.500.14551/24403Objective: To evaluate the effectiveness of trichloroacetic acid (TCA) instillation into uterine cavity for the treatment of dysfunctional uterine bleeding (DUB). Design: Prospective clinical study. Setting: A university research hospital. Patient(s): Ninety women participated who had dysfunctional uterine bleeding. Intervention(s): Ninety-five percent of TCA was instilled in to uterine cavity for endometrial ablation in women with dysfunctional uterine bleeding who want conservative treatment. Participants in group 1 received only TCA; participants in group 2 received a single dose of gonadotropin-releasing hormone analogue 1 month before the procedure. Main Outcome Measure(s): All participants underwent an evaluation that included cycle history, body mass index measurement, and transvaginal ultrasonography of pelvis, diagnostic hysteroscopy and endometrial biopsy. Result(s): At the end of 12 months of the treatment, amenorrhea rates in group 1 and group 2 were 26.7% vs. 31.1%, with pooled amenorrhea, hypomenorrhea, and eumenorrhea rate of 95.6% vs. 97.8%, respectively. There was no significant differences between the groups vis-a-vis postprocedure results. More than 90% of women who have this procedure are satisfied with the results. There were no observed negative effects or related complications with this treatment. Conclusion(s): An instillation of TCA into uterine cavity produces acceptable results and provides conservative management of DUB. (C)2005 by American Society for Reproductive Medicine.en10.1016/j.fertnstert.2004.05.100info:eu-repo/semantics/openAccessTrichloroacetic InstillationEndometrial AblationHysteroscopyEndometriumChemical DestructionDysfunctional Uterine BleedingMetrorrhagiaThermal Balloon AblationMicrowave Endometrial AblationRandomized-TrialMenorrhagiaLaserAnesthesiaResectionTherapySafetySystemArticle831189194Q1WOS:0002264452000262-s2.0-1184429845015652906Q1