Gok, MuratKurtul, AlparslanTaylan, GokayOzturk, CihanCakir, BurcuYilmaz, EfeAltay, Servet2024-06-122024-06-1220230001-53851784-973Xhttps://doi.org/10.1080/00015385.2022.2085357https://hdl.handle.net/20.500.14551/20064Objectives Co-existing chronic total occlusion (CTO) in a non-infarct-related artery (IRA) might serve as an important trigger of adverse outcomes in ST-segment elevation myocardial infarction (STEMI). Therefore, we planned to analyse the potential impact of non-IRA CTO on the evolution of contrast-associated nephropathy (CAN) in STEMI patients managed with primary percutaneous coronary intervention (P-PCI). Methods A total of 537 subjects with STEMI undergoing P-PCI during the first 12 h after the onset of their symptoms were enrolled in this retrospective study. The subjects were categorised based on the angiographic presence of non-IRA CTO. Moreover, the subjects were also divided into 2 groups based on their CAN status following P-PCI (CAN (+) and CAN (-)). Results Co-existing non-IRA CTO was demonstrated in 86 subjects (16%). During the hospitalisation period, we identified 81 (15.1%) subjects with CAN. Subjects with non-IRA CTO had a significantly higher incidence of CAN compared with those without (56 [12.4%] vs 25 [29.1%], respectively, p < 0.001). In a logistic regression analysis, an existing non-IRA CTO (odds ratio: 2.840, 95%CI: 1.451-5.558, p = 0.002), as well as age, haemoglobin, diabetes mellitus, creatinine, and white blood cell count, were independent of predictors of CAN. Conclusion In STEMI patients managed with P-PCI, a co-existing non-IRA CTO had an independent association with the evolution of CAN.en10.1080/00015385.2022.2085357info:eu-repo/semantics/closedAccessContrast-Associated NephropathyChronic Total OcclusionNon-Infarct-Related ArteryPrimary Percutaneous Coronary InterventionST-Segment Elevation Myocardial InfarctionLong-Term MortalityNoninfarct-Related ArteryAcute-Renal-FailureInterventionDiseaseArticle781118123Q4WOS:0008085035000012-s2.0-8513170083935678246Q3