Tekatas, AslanGemici, Yagmur I.Tuncel, Sedat AlpaslanCagli, BekirTastekin, EbruUnlu, ErcumentCelik, Yahya2024-06-122024-06-1220141301-062X1309-2545https://doi.org/10.4274/tnd.26122https://hdl.handle.net/20.500.14551/23341Primary leptomeningeal melanomatosis is a rare central nervous system neoplasm originating from leptomeningeal melanocytes. The cases can be presented with focal neurologic deficit, seizure, neuropsychiatric symptoms or increased intracranial pressure symptoms along with encephalitis or meningitis. Diagnosis can be made upon imaging studies, cytopathologic examination of cerebrospinal fluid and biopsy. Biopsy can return false negative since the leptomeningeal involvement is not diffuse. In this study, a case is presented who admitted to hospital with leptomenengitis symptoms such as headache, fever and altered state of consciousness and developed additional neurologic signs after months. First biopsy came out as normal while the second one did as positive. This case has been found worth presenting since this is a tumor of rare existence and the diagnosis was made upon the second biopsy.en10.4274/tnd.26122info:eu-repo/semantics/openAccessPrimary Leptomeningeal MelanomaHeadacheIncreased Intracranial PressureLeptomenengitisArticle204138140N/AWOS:0002175507000072-s2.0-84924412410Q4