Memis, DTuran, AKaramanlioglu, BGuler, TYurdakoc, APamukcu, ZTuran, N2024-06-122024-06-1220020310-057X1448-0271https://doi.org/10.1177/0310057X0203000404https://hdl.handle.net/20.500.14551/23192This randomized controlled trial examined the effects of preoperative oral erythromycin or nizatidine on gastric pH and volume. Sixty patients, ASA I and 2 status scheduled for elective surgery were studied. All subjects received oral study medication with 10 ml of water 60 minutes prior to surgery. Patients in Group I (it = 20) were given erythromycin 200 mg, in Group 2 (n = 20) nizatidine 300 mg, and in Group 3 (n = 20) placebo capsule. A nasogastric tube was inserted immediately after anaesthesia induction. Gastric content was aspirated, and volume and pH recorded. pH values determined in Group I were 5.6+/-1.87, in Group 2, 5.65+/-1.92 and in Group 3, 3.5+/-1.93. There was no statistical difference between Groups I and 2, but there was a statistically significant difference between Group 3 and Groups I and 2 (P<0.001). The volume of gastric content was 10.25+/-6.65 ml in Group 1, 10.3+/-6.29 ml in Group 2, and 20.25+/-16.72 ml in Group 3. Again, there was no statistical difference between Groups I and 2, but there was a statistically significant difference between Group 3 and Groups I and 2 (P<0.05). The proportion of patients considered at risk of significant lung injury should aspiration occur was 10% of Group 1, 5% of Group 2 and 20% of Group 3 (not statistically different). We conclude that oral erythromycin and nizatidine given one hour prior to surgery are effective in reducing gastric pH and volume.en10.1177/0310057X0203000404info:eu-repo/semantics/openAccessPneumonia Aspiration : PreventionPreoperative Erythromycin, NizatidineAcid AspirationMotilinArticle304428432Q3WOS:0001773518000042-s2.0-003602297912180579Q2