Gulyasar, T.Ozturk, L.Sipahi, T.Bayraktar, B.Metin, G.Yucesir, I.Sut, N.2024-06-122024-06-1220140231-424X1588-2683https://doi.org/10.1556/APhysiol.101.2014.2.6https://hdl.handle.net/20.500.14551/21333This study has been conducted to determine whether mean values of peak oxygen consumption (VO2peak), anaerobic test parameters and knee isokinetic test measurements are different among guanine nucleotide-binding protein, beta-3 (GNB3) genotype groups in a group of basketball players. Methods: Seventy-two healthy male (mean age, 22.9 +/- 5.3 years) basketball players from the first division of national league participated. We studied GNB3 gene c. 825C>T (rs5443) polymorphism, then divided the subjects into three groups as CC (n = 21), CT (n = 35), and TT (n = 16). Mean VO2peak, Wingate anaerobic test results, and isokinetic knee muscle strength measurements were compared among the genotype groups. Results: Mean VO2peak (60.1 +/- 3.9; 56.7 +/- 3.6; and 57.8 +/- 3.3, respectively, p < 0.01), mean anaerobic minimum power (5.1 +/- 0.4; 5.3 +/- 0.5; and 4.4 +/- 0.5 W/kg, respectively, p < 0.001), mean anaerobic power drop (57.0 +/- 6.2; 54.2 +/- 6.9; and 62.9 +/- 5.3%, respectively, p < 0.001) were significantly different among the study groups, CC, CT, and TT. Individuals with TT genotype exerted lower performance in terms of isokinetic knee muscle strength. Conclusion: The presence of 825T-allele may impair athletic performance and may serve as a genetic marker of low capacity for athletic performance in male basketball players.en10.1556/APhysiol.101.2014.2.6info:eu-repo/semantics/closedAccessGenetic PolymorphismGNB3Exercise CapacityVO2peakIsokinetic Knee StrengthBeta-3 Subunit VariantC825t Polymorphism825t AlleleAssociationHypertensionMarathonObesityGNB3 gene c.825C>T polymorphism and performance parameters in professional basketball playersArticle1012176184Q4WOS:0003370226000062-s2.0-8490218387524901079N/A